Methodology for time and TOT calibration of a modular J-PET scanner with prompt gamma emitters 22Na and 44Sc
K. Kacprzak, E. Beyene, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, M. Das, J. Hajduga, S. Jalali, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, K. Kubat, S. Kumar Kundu, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, A. Pandey, P. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, S. Sharma, M. Skurzok, A. Stolarz, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, A. Venadan, E.Ł. Stępień, P. Moskal
abstract
Objective: The goal of the work is to develop a set of methods for calibrating the positron emission tomography system built from plastic scintillators, and to present the results of the modular J-PET scanner time of flight (TOF) and time over threshold (TOT) synchronisation.
Methods: Measurements with radionuclide 22Na and 44Sc (used as a point-like source and enclosed in a collimator) were performed using the modular J-PET scanner, which detects signals from annihilation photons and prompt gamma. The data were gathered with a trigger-less data acquisition system and analysed with a dedicated software framework. The detection modules were synchronised with the procedures, correcting time offsets and normalising TOT measurements.
Results: The application of the time calibration methods yields a fully synchronised detector that is capable of producing the image of the source. TOF resolution for modular J-PET is determined to be about 490 ps (FWHM).
Conclusions: The J-PET scanner, built from plastic scintillators, can be calibrated using betta+gamma emitters and taking advantage of the fact that the direction of propagation of annihilation and prompt photons are not correlated.
Monte Carlo-Based Scatter Correction for the Plastic Based Modular PET Scanner J-PET
R. Bayerlein†, M. Das†, S. Sharma, R. D. Badawi, E. Y. Beyene, N. Chug, C. Curceanu, E. Czerwiński, K. V. Eliyan, J. Hajduga, A. Hubalewska-Dydejczyk, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, K. Kubat, S. K. Kundu, A. K. Venadan, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, M. Opalińska, P. Pandey, A. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, B. A. Spencer, A. Sowa-Staszczak, M. Skurzok, T. Szumlak, S. Tiwari, P. Tanty, K. T. Ardebili, E. Ł. Stępień, and P. Moskał.
†These authors contributed equally to this work.
abstract
First Positronium Imaging Using 44Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom
Manish Das, Sushil Sharma, Ermias Yitayew Beyene, Aleksander Bilewicz, Jarosław Choiński, Neha Chug, Catalina Curceanu, Eryk Czerwiński, Kavya Valsan Eliyan, Jakub Hajduga, Sharareh Jalali, Krzysztof Kacprzak, Tevfik Kaplanoglu, Łukasz Kapłon, Kamila Kasperska, Aleksander Khreptak, Grzegorz Korcyl, Tomasz Kozik, Karol Kubat, Deepak Kumar, Anoop Kunimmal Venadan, Edward Lisowski, Filip Lisowski, Justyna Medrala Sowa, Simbarashe Moyo, Wiktor Mryka, Szymon Niedźwiecki, Piyush Pandey, Szymon Parzych, Alessio Porcelli, Bartłomiej Rachwał, Elena Perez del Rio, Martin Rädler, Axel Rominger, Kuangyu Shi, Magdalena Skurzok, Anna Stolarz, Tomasz Szumlak, Pooja Tanty, Keyvan Tayefi Ardebili, Satyam Tiwari, Rafał Walczak, Ewa Ł. Stępień, Paweł Moskal
abstract
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph?the first plastic scintillators-based PET scanner.
First Positronium Lifetime Imaging using 52Mn and 55Co with a plastic-based PET scanner
M. Das, S. Sharma, E. Y. Beyene, A. Bilewicz, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, J. Hajduga, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, S. Kumar Kundu, A. Kunimmal Venadan, E. Lisowski, F. Lisowski, J. Medrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, A. Pandey, P. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, N. Rathod, N. Razzaq, A. Rominger, K. Shi, M. Skurzok, M. Słotwiński, A. Stolarz, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, K. Valsan Eliyan, R. Walczak, E. Ł. Stępień, P. Moskal
abstract
This study demonstrates applicability of 52Mn and 55Co radionuclides for positronium imaging. Positronium Lifetime Imaging
(PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular
architecture. However, its practical use requires ?+ emitters that also provide an additional prompt ? ray to mark the positron creation time. In this work, we report the first PLI measurements performed with 52Mn and 55Co using the modular J-PET. Four samples were studied in each experiment: two Certified Reference Materials (polycarbonate and fused silica) and two
human tissues (cardiac myxoma and adipose). The selection of PLI events was based on the registration of two 511 keV
annihilation photons and one prompt gamma in triple coincidence. From the resulting lifetime spectra we extracted the mean
ortho-positronium lifetime ?oPs and the mean positron lifetime ?Tmean for each sample. The measured values of ?oPs in
polycarbonate using both isotopes matches well with the certified reference values. Furthermore, 55Co reproduced identical
results for fused-silica measurements at their respective uncertainty levels. In contrast, measurements with 52Mn in fused silica show a minor deviation, which could be caused by the Parafilm spacer. In myxoma and adipose tissue, the reduced ?oPs values are mainly linked to the long storage history of the samples rather than to the choice of isotope. Comparing peak-to-background ratios and spectral purity, 55Co provides cleaner PLI data under the same experimental conditions. Although 52Mn offers a longer half-life and a multi gamma cascade enhancing ?+ + ? coincidences, but at the expense of higher background. In this study, we demonstrate that the applied selection criteria on the data measured with the modular J-PET can be used for PLI studies even with radionuclides with complex decay patterns.
First ex-vivo positronium imaging of tissues with modular J-PET scanner using 44Sc radionuclide
K. Kubat, M. Das, S. Sharma, E. Y. Beyene, A. Bilewicz, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, J. Hajduga, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, D. Kumar, S. Kumar Kundu, A. Kunimmal-Venadan, B. Leszczyński, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, A. Pandey, P. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, M. Skurzok, A. Stolarz, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, K. Valsan Eliyan, R. Walczak, P. Moskal, E. Ł. Stępień
abstract
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the 44Sc radionuclide. The 44Sc isotope was produced via the 44Ca(p, n)44Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of 44Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with 44Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential Sc radionuclide for positronium lifetime imaging (PLI).
Studies of CPT symmetry in positronium decays with 192 plastic strip J-PET detector
N. Chug, S. D. Bass, E. Y. Beyene, C. Curceanu, E. Czerwiński, M. Das, K. V. Eliyan, M. Gorgol, J. Hajduga, S. Jalali, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, A. Kierys, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, A. Kunimmal Venadan, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, P. Pandey, S. Parzych, E. Pérez del Río, A. Porcelli, B. Rachwał, M. Rädler, A. Sienkiewicz, S. Sharma, M. Skurzok, E. Ł. Stępień, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, P. Moskal
abstract
A direct test of the CPT symmetry is performed for the electromagnetic decays of ortho-positronium using the Jagiellonian positron emission tomograph (J-PET). We present the precise measurement of the CPT-sensitive angular correlation entailing the positronium spin and the momenta of its annihilation photons, surpassing previous studies utilizing the same detection system. Positrons originating from a 22Na source are emitted from the detector?s center and subsequently form positronium atoms within the spherical chamber covered with porous material. Reconstruction of annihilation locations using the 192-strip J-PET detector makes it possible to determine the positronium emission direction, which defines the quantization axis along which positronium is polarized, without the application of external magnetic fields. The measurements were performed in total for 356 days resulting in an identification of 47.8×10^6 events with ortho-positronium decays into three photons. The results are consistent with the exactness of CPT symmetry with measured asymmetry amplitude -0.00029+-0.00022 (stat.) and with statistical error four times smaller than the previous best measurement.
Nanoporosity imaging by positronium lifetime tomography
K. Dulski, E. Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, M. Gorgol, B. Jasińska, K. Kacprzak, Ł. Kapłon, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Niedźwiecki, P. Pandey, S. Parzych, E. Perez del Rio, M. Rädler, S. Sharma, M. Skurzok, K. Tayefi, P. Tanty, E.Ł. Stępień, P. Moskal
abstract
Positron Annihilation Lifetime Spectroscopy (PALS) is a well-established non-destructive technique used for nanostructural characterization of porous materials. It is based on the annihilation of a positron and an electron. Mean positron lifetime in the material depends on the free voids size and molecular environment, allowing the study of porosity and structural transitions in the nanometer scale. We have developed a novel method enabling spatially resolved PALS, thus providing tomography of nanostructural characterization of an extended object. Correlating space (position) and structural (lifetime) information brings new insight in materials studies, especially in the characterization of the purity and pore distribution. For the first time, a porosity image using stationary positron sources for the simultaneous measurement of the porous polymers XAD4, silica aerogel powder IC3100, and polyvinyl toluene scintillator PVT by the J-PET (Jagiellonian Positron Emission Tomography) system is demonstrated.
Quality control of plastic scintillators for the total-body J-PET scanner
Ł. Kapłon, E. Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, K. Eliyan, K. Kacprzak, T. Kaplanoglu, G. Korcyl, K. Kubat, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, G. Moskal, W. Mryka, S. Niedźwiecki, P. Pandey, S. Parzych, E. Pérez del Rio, S. Sharma, M. Skurzok, P. Tanty, K. Tayefi, A. Venadan, E. Stępień and P. Moskal
abstract
The construction of the total-body Jagiellonian positron emission tomography scanner requires component verification before detector assembly. The purpose of this research is to verify the quality of BC-408 plastic scintillators with dimensions 6 mm × 30 mm × 330 mm. The scintillators were inspected for optical and mechanical defects and all dimensions were measured. Scratches, mechanically damaged corners and edges, as well as encapsulated dust and fibers within the scintillators, were identified under ceiling lamp illumination. Line defects on the as-cast surfaces were easily visible in a plane polariscope setup consisting of crossed horizontal and vertical polarizer foils. The transmittance at the wavelength of maximum emission through 6 mm thick scintillator samples and the technical attenuation length along 330 mm long scintillator samples were measured on a linear CCD array spectrometer for randomly selected scintillators from each delivered batch. Selected properties of the emission spectra, such as their FWHM and the values of the emission maxima as a function of the distance between the excitation point and the spectrometer fiber, were measured. Additionally, the scintillators optical homogeneity was measured on a light transfer setup consisting of an LED and photodiode matrix. The majority of the obtained plastic scintillators meets the transparency criteria and falls within the dimensional tolerances.
muPPET: Investigating the Muon Puzzle with J-PET Detectors
A. Porcelli, K. Valsan Eliyan, G. Moskal, N. Nasrin Protiti, D. L. Sirghi, E. Yitayew Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, M. Gorgol, J. Hajduga, S. Jalali, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, D. Kumar, K. Kubat, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, W. Mryka, S. Moyo, S. Niedźwiecki, S. Parzych, P. Pandey, E. Perez del Rio, B. Rachwał, M. Rädler, S. Sharma, M. Skurzok, E. Ł. Stępień, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, and P. Moskal
abstract
The muPPET [muon Probe with J-PET] project aims to investigate the Muon
Puzzle seen in cosmic ray air showers. This puzzle arises from the observation of a significantly
larger number of muons on Earth's surface than that predicted by the current
theoretical models. The investigated hypothesis is based on recently observed asymmetries
in the parameters for the strong interaction cross-section and trajectory of an outgoing particle
due to projectile-target polarization. The measurements require detailed information
about muons at the ground level, including their track and charge distributions. To achieve
this, the two PET scanners developed at the Jagiellonian University in Krakow (Poland),
the J-PET detectors, will be employed, taking advantage of their well-known resolution
and convenient location for detecting muons that reach long depths in the atmosphere.
One station will be used as a muon tracker, while the second will reconstruct the core of
the air shower. In parallel, the existing hadronic interaction models will be modified and
fine-tuned based on the experimental results. In this work, we present the conceptualization
and preliminary designs of muPPET.
Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a novel plastic PET scanner
P. Moskal, D. Kumar, S. Sharma, E.Y. Beyene, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Das, K. Dulski, M. Gorgol, B. Jasinska, K. Kacprzak, T. Kaplanoglu, L. Kaplon, T. Kozik, E. Lisowski, F. Lisowski, W. Mryka, S. Niedzwiecki, S. Parzych, E.P. del Rio, M. Radler, M. Skurzok, E. L. Stepien, P. Tanty, K. Tayefi Ardebili, K. Valsan Eliyan
abstract
In the state-of-the-art Positron Emission Tomography (PET), information about the polarization of annihilation photons is not available. Current PET systems track molecules labeled with positron-emitting radioisotopes by detecting the propagation direction of two photons from positron-electron annihilation. However, annihilation photons carry more information than just the site where they originated. Here we present a novel J-PET scanner built from plastic scintillators, in which annihilation photons interact predominantly via the Compton effect, providing information about photon polarization in addition to information on photon direction of propagation. Theoretically, photons from the decay of positronium in a vacuum are maximally entangled in polarization. However, in matter, when the positron from positronium annihilates with the electron bound to the atom, the question arises whether the photons from such annihilation are maximally entangled. In this work, we determine the distribution of the relative angle between polarization orientations of two photons from positron-electron annihilation in a porous polymer. Contrary to prior results for positron annihilation in aluminum and copper, where the strength of observed correlations is as expected for maximally entangled photons, our results show a significant deviation. We demonstrate that in porous polymer, photon polarization correlation is weaker than for maximally entangled photons but stronger than for separable photons. The data indicate that more than 40% of annihilations in Amberlite resin lead to a non-maximally entangled state. Our result indicates the degree of correlation depends on the annihilation mechanism and the molecular arrangement. We anticipate that the introduced Compton interaction-based PET system opens a promising perspective for exploring polarization correlations in PET as a novel diagnostic indicator.
Realistic total-body J-PET geometry optimization: Monte Carlo study
J. Baran, W. Krzemień, L. Raczyński, M. Bała, A. Coussat, S. Parzych, N. Chug, E. Czerwiński, C. Oana Curceanu, M. Dadgar, K. Dulski, K. Eliyan, J. Gajewski, A. Gajos, B. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, G. Korcyl, T. Kozik, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Skurzok, E. Stępień, F. Tayefiardebili, K. Tayefiardebili, W. Wiślicki, P. Moskal
abstract
Total-Body PET imaging is one of the most promising newly introduced modalities in the medical diagnostics. State-of-the-art PET scanners use inorganic scintillators such as L(Y)SO or BGO, however, those technologies are very expensive, prohibitng the broad total-body PET applications. We present the comparative studies of performance characteristics of the cost-effective Total-Body PET scanners using Jagiellonian PET (J-PET) technology that is based on plastic scintillators. Here, we investigated in silico five realistic Total-Body scanner geometries, varying the number of rings, scanner radius, and distance between the neighbouring rings. Monte Carlo simulations of two NEMA phantoms (2-meter sensitivity line source and image quality) and the anthropomorphic XCAT phantom, were used to assess the performance of the tested geometries. We compared the sensitivity profiles and we performed the quantitative analysis of the reconstructed images by using the quality metrics such as contrast recovery coefficient, background variability and root mean squared error. The optimal scanner design was selected for the first Total-Body J-PET scanner configuration.
Calibration of PALS System with CRM Materials for Biomedical Studies
K. Kubat, Ł. Kapłon, P. Moskal, E. Stępień
abstract
Objective and method: Positron annihilation lifetime spectroscopy (PALS) is a powerful technique in material science that allows the investigation of the properties and behavior of positrons in various materials. PALS can be used to investigate solid structures at the nanometer scale and enable the use of positronium properties as an additional diagnostic parameter. Here we present results from calibration of the PALS system with certificated reference materials (CRM).
Materials: Source of 22Na covered with layer of Kapton film, and after that parafilm from both sides was used in all experiments. Certified materials of No_5602-a (polycarbonate) and No_5601-a (fused silica) were used to ascertain if parameters were correctly identified.
Results: In an experiment three lifetime components were correctly identified. All of those components will always be present in the data in further experiments on biological samples. Lifetime components consist of: 196 ps for annihilations in AI an aluminium cover of the chamber, 386 ps for annihilations in thesource and in the Kapton foil, 463 ps for reactions with parafilm.
Conclusions: These parameters will be further used to correctly identify positron lifetimes in biological samples. Recently, a new method for imaging of positronium properties was invented and the first in-vivo images of positronium lifetime in humans were demonstrated with the multi-photon J-PET scanner. In order to correlate the positronium properties in tissue with the medically useful parameters, and to translate positronium imaging to clinics, comprehensive research of positronium properties in biological samples is needed.
Positronium image of the human brain in vivo
P. Moskal, J. Baran, S. Bass, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, M. Das, K. Dulski, K.V. Eliyan, K. Fronczewska, A. Gajos, K. Kacprzak, M. Kajetanowicz, T. Kaplanoglu, Ł. Kapłon, K. Klimaszewski, M. Kobylecka, G. Korcyl, T. Kozik, W. Krzemień, K. Kubat, D. Kumar, J. Kunikowska, J. Mączewska, W. Migdał, G. Moskal, W. Mryka, S. Niedźwiecki, S. Parzych, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, F. Tayefi, K. Tayefi, P. Tanty, W. Wiślicki, L. Królicki, E. Ł. Stępień
abstract
Positronium is abundantly produced within the molecular voids of a patient?s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
Feasibility of the J-PET to monitor range oftherapeutic proton beams
J. Baran, D. Borys, K. Brzeziński, J. Gajewski, M. Silarski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K.V. Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopeć, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A.J. Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, M. Simbarashe, S. Sharma, Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E.Ł. Stępień, K. Tayefi, F. Tayefi, D.C. Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Ruciński
abstract
Objective: The aim of this work is to investigate the feasibility of the JagiellonianPositron Emission Tomography (J-PET) scanner for intra-treatment proton beamrange monitoring. Approach: The Monte Carlo simulation studies with GATE and PET imagereconstruction with CASToR were performed in order to compare six J-PET scannergeometries (three dual-heads and three cylindrical). We simulated proton irradiationof a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out BraggPeak (SOBP) of various ranges. The sensitivity and precision of each scanner werecalculated, and considering the setup?s cost-effectiveness, we indicated potentiallyoptimal geometries for the J-PET scanner prototype dedicated to the proton beamrange assessment. Main results: The investigations indicate that the double-layer cylindrical andtriple-layer double-head configurations are the most promising for clinical application.We found that the scanner sensitivity is of the order of 10?5coincidences per primaryproton, while the precision of the range assessment for both SPB and SOBP irradiationplans was found below 1 mm. Among the scanners with the same number of detectormodules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibilityof the J-PET detector for PET-based proton beam therapy range monitoring ispossible with reasonable sensitivity and precision enabling its pre-clinical tests in theclinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometryconfigurations seem promising for the future clinical application. Experimental testsare needed to confirm these findings.
Feasibility studies for imaging e+e- annihilation with modular multi-strip detectors
S. Sharma, L. Povolo, S. Mariazzi, G. Korcyl, K. Kacprzak, D. Kumar, S. Niedzwiecki, J. Baran, E. Beyene, R. S. Brusa, R. Caravita, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Dadgar, M. Das, K. Dulski, K. Eliyan, A. Gajos, N. Gupta, B. C. Hiesmayr, L. Kaplon, T. Kaplanoglu, K. Klimaszewski, P. Konieczka, T. Kozik, M. K. Kozani, W. Krzemien, S. Moyo, W. Mryka, L. Penasa, S. Parzych, E. Perez Del Rio, L. Raczynski, R. Y. Shopa, M. Skurzok, E. L. Stepien, P. Tanty, F. Tayefi, K. Tayefi, W. Wislicki, P. Moskal
abstract
Studies based on imaging the annihilation of the electron (e-) and its antiparticle positron (e+) open up several interesting applications in nuclear medicine and fundamental research. The annihilation process involves both the direct conversion of ee into photons and the formation of their atomically bound state, the positronium atom (Ps), which can be used as a probe for fundamental studies. With the ability to produce large quantities of Ps, manipulate them in long-lived Ps states, and image their annihilations after a free fall or after passing through atomic interferometers, this purely leptonic antimatter system can be used to perform inertial sensing studies in view of a direct test of Einstein equivalence principle. It is envisioned that modular multistrip detectors can be exploited as potential detection units for this kind of studies. In this work, we report the results of the first feasibility study performed on a e beamline using two detection modules to evaluate their reconstruction performance and spatial resolution for imaging ee annihilations and thus their applicability for gravitational studies of Ps.
Discrete symmetries tested at 10^-4 precision using linear polarization of photons from positronium annihilations
P. Moskal, E. Czerwiński, J. Raj, S. D. Bass, E. Beyene, N. Chug, A. Coussat, C. Curceanu, M. Dadgar, M. Das, K. Dulski, A. Gajos, M. Gorgol, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, S. Moyo, W. Mryka, S. Niedźwiecki, S. Parzych, E. Pérez del Río, L. Raczyński, S. Sharma, S. Choudhary, R. Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, P. Tanty, F. T. Ardebili, K. T. Ardebili, K. V. Eliyan, W. Wiślicki
abstract
Discrete symmetries play an important role in particle physics with violation of CP connected to the matter-antimatter imbalance in the Universe. We report the most precise test of P, T and CP invariance in decays of ortho-positronium, performed with methodology involving polarization of photons from these decays. Positronium, the simplest bound state of an electron and positron, is of recent interest with discrepancies reported between measured hyperfine energy structure and theory at the level of 10^-4 signaling a need for better understanding of the positronium system at this level. We test discrete symmetries using photon polarizations determined via Compton scattering in the dedicated J-PET tomograph on an event-by-event basis and without the need to control the spin of the positronium with an external magnetic field, in contrast to previous experiments. Our result is consistent with QED expectations at the level of 0.0007 and one standard deviation.
Comparison of cell casted and 3D-printed plastic scintillators for dosimetry applications
D. Kulig, Ł. Kapłon, G. Moskal, S. Beddar, T. Fiutowski, W. Górska, J. Hajduga, P. Jurgielewicz, D. Kabat, K. Kalecińska, M. Kopeć, S. Koperny, B. Mindur, J. Moroń, S. Niedźwiecki, M. Silarski, F. Sobczuk, T. Szumlak, A. Ruciński
abstract
Currently, the most used methods of plastic scintillator (PS) manufacturing are cell casting and bulk polymerisation, extrusion, injection molding, whereas digital light processing (DLP) 3D printing technique has been recently introduced. For our research, we measured blue-emitting EJ-200, EJ-208, green-emitting EJ-260, EJ-262 cell cast and two types of blue-emitting DLP-printed PSs. The light output of the samples, with the same dimension of 10 mm × 10 mm × 10 mm, was compared. The light output of the samples, relative to the reference EJ-200 cell-cast scintillator, equals about 40?49 and 70?73% for two types of 3D-printed, and two green-emitting cell-casted PSs, respectively. Performance of the investigated scintillators is sufficient to use them in a plastic scintillation dosemeter operating in high fluence gamma radiation fields.
Comparative studies of the sensitivities of sparse and full geometries of Total-Body PET scanners built from crystals and plastic scintillators
M. Dadgar, S. Parzych, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, K. Dulski, K. Elyan, A. Gajos, B.C. Hiesmayr, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, M. Skurzok, E. L. Stępień, F. Tayefi Ardebili, K. Tayefi Ardebili, S. Vandenberghe, W. Wiślicki and P. Moskal
abstract
Background: Alongside the benefits of Total-Body imaging modalities, such as higher sensitivity, single-bed position, low dose imaging, etc., their final construction cost prevents worldwide utilization. The main aim of this study is to present a simulation-based comparison of the sensitivities of existing and currently developed tomographs to introduce a cost-efficient solution for
constructing a Total-Body PET scanner based on plastic scintillators.
Methods: For the case of this study, eight tomographs based on the uEXPLORER configuration with different scintillator materials (BGO, LYSO), axial field-of-view (97.4 cm and 194.8 cm), and detector configuration (full and sparse) were simulated. In addition, 8 J-PET scanners with different configurations, such as various axial field-of-view (200 cm and 250 cm), the different cross-sections of plastic scintillator, and the multiple numbers of the
plastic scintillator layers (2, 3, and 4), based on J-PET technology have been simulated by GATE software. Furthermore, Biograph Vision has been simulated to compare the results with standard PET scans. Two types of simulations have been performed. The first one with a centrally located source with a diameter of 1mm and a length of 250 cm, and the second one with the same source inside a water-filled cylindrical phantom with a diameter of 20 cm and a length of 183 cm.
Results: With regards to sensitivity, among all the proposed scanners, the ones constructed with BGO crystals give the best performance (? 350 cps/kBq at the center). The utilization of sparse geometry or LYSO crystals significantly lowers the achievable sensitivity of such systems. The J-PET design gives a similar sensitivity to the sparse LYSO crystal-based detectors while having full detector coverage over the body. Moreover, it provides uniform sensitivity over the body
with additional gain on its sides and provides the possibility for high-quality brain
imaging.
Conclusion: Taking into account not only the sensitivity but also the price of the Total-Body PET tomographs, which till now was one of the main obstacles in their widespread clinical availability, the J-PET tomography system based on plastic scintillators could be a cost-efficient alternative for Total-Body PET scanners.
Monte Carlo simulations of the underwater detection of illicit war remnants with neutron-based sensors
M. Silarski, P. Sibczyński, O. Bezshyyko, Ł. Kapłon, V. Kumar, S. Niedźwiecki, M. Nowakowski, P. Moskal, S. Sharma, F. Sobczuk
abstract
In recent years, the demand for accurate detection and identification of hazardous substances in an aquatic environment, especially in the Baltic Sea, has seen a significant rise, with a specific focus on unexploded ordnance (UXO) containing conventional explosives and various chemical agents, including, but not limited to, mustard gas, Clark I and II and other lethal compounds. These substances pose a significant threat to human health and the environment, and their identification is crucial for effective demining and environmental protection efforts. In this article, a novel approach for fast, remote, and non-destructive recognition of dangerous substances based on a SABAT sensor installed on an ROV is described. The performance of the proposed neutron-based sensor in an aquatic environment was verified based on a series of Monte Carlo simulations for mustard gas, Clark I and II, and TNT, as they are the most common chemical threats at the bottom of the Baltic Sea. The sensor?s ability to accurately discriminate hazardous and non-hazardous materials is described in the paper in terms of the ratio of chlorine to hydrogen (Cl/H), carbon to oxygen (C/O), and nitrogen to hydrogen (N/H) activation lines integrals. The authors also discussed the future directions of work to validate SABAT (Stoichiometry Analysis By Activation Techniques) sensors in the operational environment.
Transformation of PET raw data into images for event classification using convolutional neural networks
P. Konieczka, L. Raczyński, W. Wiślicki, O. Fedoruk, K. Klimaszewski, P. Kopka, W. Krzemień, R.Y. Shopa, J. Baran, A. Coussat, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, G. Korcyl, T. Kozik, D. Kumar, S. Niedźwiecki, S. Parzych, E. Pérez del Río, S. Sharma, S. Shivani, M. Skurzok, E.Ł. Stępień, F. Tayefi, P. Moskal
abstract
In positron emission tomography (PET) studies, convolutional neural networks (CNNs) may be applied directly to the reconstructed distribution of radioactive tracers injected into the patient's body, as a pattern recognition tool. Nonetheless, unprocessed PET coincidence data exist in tabular format. This paper develops the transformation of tabular data into -dimensional matrices, as a preparation stage for classification based on CNNs. This method explicitly introduces a nonlinear transformation at the feature engineering stage and then uses principal component analysis to create the images. We apply the proposed methodology to the classification of simulated PET coincidence events originating from NEMA IEC and anthropomorphic XCAT phantom. Comparative studies of neural network architectures, including multilayer perceptron and convolutional networks, were conducted. The developed method increased the initial number of features from 6 to 209 and gave the best precision results (79.8) for all tested neural network architectures; it also showed the smallest decrease when changing the test data to another phantom.
Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study
K. Brzeziński, J. Baran, D. Borys, J. Gajewski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K.V. Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopeć, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A.J. Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E.Ł. Stępień, K. Tayefi, F. Tayefi, D.C. Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Ruciński
abstract
Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r2 = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.
Comparative studies of plastic scintillator strips with high technical attenuation length for the total-body J-PET scanner
Ł. Kapłon, J. Baran, N. Chug, A. Coussat, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, B. Hiesmayr, E. Kavya Valsan, K. Klimaszewski, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, G. Moskal, S. Niedźwiecki, D. Panek, S. Parzych, E. Pérez del Rio, L. Raczyński, A. Ruciński, S. Sharma, S. Shivani, R. Shopa, M. Silarski, M. Skurzok, E. Stępień, F. Tayefi Ardebili, K. Tayefi Ardebili, W. Wiślicki, P. Moskal
abstract
Plastic scintillator strips are considered as one of the promising solutions for the cost-effective construction of total-body positron emission tomography, (PET) system. The purpose of the performed measurements is to compare the transparency of long plastic scintillators with dimensions 6 mm x 24 mm x 1000 mm and with all surfaces polished. Six different types of commercial, general purpose, blue-emitting plastic scintillators with low attenuation of visible light were tested, namely: polyvinyl toluene-based BC-408, EJ-200, RP-408, and polystyrene-based Epic, SP32 and UPS-923A. For determination of the best type of plastic scintillator for total-body Jagiellonian positron emission tomograph (TB-J-PET) construction, emission and transmission spectra, and technical attenuation length (TAL) of blue light-emitting by the scintillators were measured and compared. The TAL values were determined with the use of UV lamp as excitation source, and photodiode as light detector. Emission spectra of investigated scintillators have maxima in the range from 420 nm to 429 nm. The BC-408 and EJ-200 have the highest transmittance values of about 90% at the maximum emission wavelength measured through a 6 mm thick scintillator strip and the highest technical attenuation length reaching about 2000 mm, allowing assembly of long detection modules for time-of-flight (TOF) J-PET scanners. Influence of the 6 mm × 6 mm, 12 mm × 6 mm, 24 mm × 6 mm cross-sections of the 1000 mm long EJ-200 plastic scintillator on the TAL and signal intensity was measured. The highest TAL value was determined for samples with 24 mm × 6 mm cross-section.
Efficiency determination of J-PET: first plastic scintillators-based PET scanner
S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, Sz. Niedźwiecki, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, Shivani, R. Y. Shopa, M. Skurzok, E. Ł. Stępień, F. Tayefi, K. Tayefi , W. Wiślicki and P. Moskal
abstract
Background:
The Jagiellonian Positron Emission Tomograph is the 3-layer prototype
of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators
are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV
photons emitted in e+e- annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures
the precise labeling of the 511 keV photons.
Results:
By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70-270 keV, where it varies between 20 and 100%. In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons.
Conclusion:
A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion-beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.
J-PET detection modules based on plastic scintillators for performing studies with positron and positronium beams
S. Sharma, J. Baran, R.S. Brusa, R. Caravita, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, B.C. Hiesmayr, K. Kacprzak, L. Kaplon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien D. Kumar, S. Mariazzi, S. Niedźwiecki, L. Panasa, S. Parzych, L. Povolo, E. Perez del Rio, L. Raczynski Shivani, R.Y. Shopa, M. Skurzok, E.L. Stepien, F. Tayefi, K. Tayefi, W. Wislicki and P. Moskal
abstract
The J-PET detector, which consists of inexpensive plastic scintillators, has demonstrated its potential in the study of fundamental physics. In recent years, a prototype with 192 plastic scintillators arranged in 3 layers has been optimized for the study of positronium decays. This allows performing precision tests of discrete symmetries (C, P, T) in the decays of positronium atoms. Moreover, thanks to the possibility of measuring the polarization direction of the photon based on Compton scattering, the predicted entanglement between the linear polarization of annihilation photons in positronium decays can also be studied. Recently, a new J-PET prototype was commissioned, based on a modular design of detection units. Each module consists of 13 plastic scintillators and can be used as a stand-alone, compact and portable detection unit. In this paper, the main features of the J-PET detector, the modular prototype and their applications for possible studies with positron and positronium beams are discussed. Preliminary results of the first test experiment performed on two detection units in the continuous positron beam recently developed at the Antimatter Laboratory (AML) of Trento are also reported.
TOF MLEM Adaptation for the Total-Body J-PET with a Realistic Analytical System Response Matrix
R.Y. Shopa, J. Baran, K. Klimaszewski, W. Krzemień, L. Raczyński, W. Wiślicki, K. Brzeziński, N. Chug, A. Coussat, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, B.C. Hiesmayr, E. Kavya Valsan, G. Korcyl, T. Kozik, D. Kumar, Ł. Kapłon, G. Moskal, S. Niedźwiecki, D. Panek, S. Parzych, E. Pérez del Rio, A. Ruciński, S. Sharma, Shivani, M. Silarski, M. Skurzok, E. Stepień, F. Tayefi Ardebili, K. Tayefi Ardebili, P. Moskal
abstract
We report a study of the original image reconstruction algorithm based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM), developed for the total-body (TB) Jagiellonian PET (J-PET) scanners. The method is applicable to generic cylindrical or modular multi-layer layouts and is extendable to multi-photon imaging. The system response matrix (SRM) is represented as a set of analytical functions, uniquely defined for each pair of plastic scintillator strips used for the detection. A realistic resolution model (RM) in detector space is derived from fitting the Monte Carlo simulated emissions and detections of annihilation photons on oblique transverse planes. Additional kernels embedded in SRM account for TOF, parallax effect and axial smearing. The algorithm was tested on datasets, simulated in GATE for the NEMA IEC and static XCAT phantoms inside a 24-module 2-layer TB J-PET. Compared to the reference TOF MLEM with none or a shift-invariant RM, an improvement was observed, as evaluated by the analysis of image quality, difference images and ground truth metrics. We also reconstructed the data with additive contributions, pre-filtered geometrically and with non-TOF scatter correction applied. Despite some deterioration, the obtained results still capitalise on the realistic RM with better edge preservation and superior ground truth metrics. The envisioned prospects of the TOF MLEM with analytical SRM include its application in multi-photon imaging and further upgrade to account for the non-collinearity, positron range and other factors.
A modular data acquisition system for reconstruction of radiation dose spatial distribution in radiotherapy treatment planning
P. Jurgielewicz, M. Filipek, T. Fiutowski, D. Kabat, K. Kalecińska, Ł. Kapłon, M. Kopeć, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, T. Szumlak, B. Mindur
abstract
In this work we propose the complete Data Acquisition (DAQ) system for measurement of volumetric radiotherapeutic dose deposition in tissue-like phantoms based on 3D printed plastic scintillators. The DAQ is easily extensible thanks to the modular architecture of its hardware and software components. We show results from the full measurement chain indicating proper operation of the system.
A reconfigurable detector for measuring the spatial distribution of radiation dose for applications in the preparation of individual patient treatment plans
M. Kopeć, T. Fiutowski, P. Jurgielewicz, D. Kabat, K. Kalecińska, Ł. Kapłon, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, T. Szumlak, B. Mindur
abstract
In this work, a novel reconfigurable Dose-3D detector intended for a full spatial therapeutic dose measurement to improve radiotherapy treatment planning is presented. The device is composed of a reconfigurable detection phantom allowing patient-centric adjustments to its geometry, a scalable data acquisition system (including hardware, firmware, and low-level software) designed to change with the phantom?s configuration seamlessly, and a high-level software package for tumour geometry extraction based on computer tomography scans. Extracted geometry will be used in the Monte Carlo simulations and the configuration of the phantom. Each of the components to be used in the measurement system has been assessed obtaining the following results. The scintillating voxels? light output is sufficient. The data acquisition system with its hardware and software has been tested using artificial testing signals and laser light proving a reliable and robust means of physics data reconstruction.
Medical imaging data analysis using 3D deep learning models towards improving the individual treatment plans
K. Kalecińska, T. Fiutowski, P. Jurgielewicz, D. Kabat, B. Rachwał, Ł. Kapłon, M. Kopeć, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, B. Mindur, T. Szumlak
abstract
This work is a part of a research project aiming at delivering the next generation active medical phantom, Dose-3D, with high spatial granulation for quasi-real time measurement of the volumetric radiotherapeutic dose deposited during photon therapy. The preliminary results, discussed here, pertain to the intelligent medical data augmentation using Generative Adversarial Networks (GANs) technique implemented inside MONAI framework. However, in the scope of the project, we perform a broad search for the most efficient and advanced Deep Learning (DL) models to create tools for 3D Computed Tomography (CT) images segmentation and cancer diagnosis improvement that will be an integral part of the custom designed software platform for processing data collected with Dose-3D phantom. Apart from the innovative detection system the software itself may prove to be disruptive in the context of the currently available tools by offering open-source high quality toolkit for wide use in everyday clinical applications.
ProTheRaMon - a GATE simulation framework for proton therapy range monitoring using PET imaging
D. Borys, J. Baran, K.W. Brzezinski, J. Gajewski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K. Valsan Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopec, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A. John Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Pérez del Río, L. Raczyński, S. Sharma, S. Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E. Stępień, K. Tayefi Ardebili, F. Tayefi, D. Charles Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Rucinski
abstract
Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach: The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results: ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance: We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github.
Investigation of the light output of 3D-printed plastic scintillators for dosimetry applications
Ł. Kapłon, D. Kulig, S. Beddar, T. Fiutowski, W. Górska, J. Hajduga, P. Jurgielewicz, D. Kabat, K. Kalecińska, M. Kopeć, S. Koperny, B. Mindur, J. Moroń, G. Moskal, S. Niedźwiecki, M. Silarski, F. Sobczuk, T. Szumlak, A. Ruciński
abstract
Three-dimensional (3D) printing, specifically digital light processing (DLP) technique, can be used to manufacture plastic scintillators of any shape. The purpose of this study was to determine the light output of DLP 3Dprinted scintillators for dosimetry applications. Two types of plastic scintillators with dimensions 10 mm × 10 mm × 10 mm were fabricated using DLP 3D-printing at Hanyang University, South Korea. The light output of these DLP 3D-printed samples was measured and compared to that of a commercial plastic scintillator of the same dimensions, RP-408, produced by casting. The 3D-printed scintillators emitting violet and blue light had a lower relative light output by 49% and 43%, respectively, compared to the RP-408 reference scintillator. We also investigated three types of scintillator surface finishing methods: the original surface made by the 3D printer, a sanded surface, and a polished surface. Furthermore, three wrapping configurations were tested: bare scintillator, diffuse-type polytetrafluoroethylene tape, and specular-type enhanced specular reflector foil. Both reflector types, diffuse and specular, reflected blue light with comparable efficiency. Additionally, emission and transmission spectra of the samples were measured. Emission maxima were located at 430 nm for RP-408, and 438 and 475 nm for two 3D-printed samples. Transmittance at the wavelength of maximum emission was equal to 89% for RP-408, and 73% and 66% for the two DLP-printed samples. Although the light output of the 3D-printed scintillators was about 50% lower than that of the commercial plastic scintillator, due to characteristics of 3Dprinted plastic scintillators, i.e. fast, low-cost production, and easy customization of the printed shape, they are promising as an active part of dosimeters for use in high intensity gamma radiation fields produced by medical linear accelerators with acceptable signal-to-noise ratio level.
Positronium imaging with the novel multiphoton PET scanner
P. Moskal, K. Dulski, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, J. Gajewski, A. Gajos, G. Grudzień, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, H. Karimi, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, P. Małczak, S. Niedźwiecki, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński, J. Raj, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E.Ł. Stępień, M. Szczepanek, F. Tayefi, W. Wiślicki
abstract
In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient?s body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O2; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do not allow acquisition of positronium images. This study presents a new method that enables positronium imaging by simultaneous registration of annihilation photons and deexcitation photons from pharmaceuticals labeled with radionuclides. The first positronium imaging of a phantom built from cardiac myxoma and adipose tissue is demonstrated. It is anticipated that positronium imaging will substantially
enhance the specificity of PET diagnostics.
Optimisation of the event-based TOF filtered back-projection for online imaging in total-body J-PET
R.Y. Shopa, K. Klimaszewski, P. Kopka, P. Kowalski, W. Krzemień, L. Raczyński, W. Wiślicki, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, D. Kisielewska, G. Korcyl, N. Krawczyk, E. Kubicz, Sz. Niedźwiecki, J. Raj, S. Sharma, Shivani, E.Ł. Stępień, F. Tayefi, P. Moskal
abstract
We perform a parametric study of the newly developed time-of-flight (TOF) image reconstruction algorithm, proposed for the real-time imaging in total-body Jagiellonian PET (J-PET) scanners. The asymmetric 3D filtering kernel is applied at each most likely position of electron-positron annihilation, estimated from the emissions of back-to-back gamma-photons. The optimisation of its parameters is studied using Monte Carlo simulations of a 1-mm spherical source, NEMA IEC and XCAT phantoms inside the ideal J-PET scan- ner. The combination of high-pass filters which included the TOF filtered back-projection (FBP), resulted in spatial resolution, 1.5 times higher in the axial direction than for the conventional 3D FBP. For real- istic 10-minute scans of NEMA IEC and XCAT, which require a trade-offbetween the noise and spatial resolution, the need for Gaussian TOF kernel components, coupled with median post-filtering, is demon- strated. The best sets of 3D filter parameters were obtained by the Nelder-Mead minimisation of the mean squared error between the resulting and reference images. The approach allows training the recon- struction algorithm for custom scans, using the IEC phantom, when the temporal resolution is below 50 ps. The image quality parameters, estimated for the best outcomes, were systematically better than for the non-TOF FBP.
Testing CPT symmetry in ortho-positronium decays with positronium annihilation tomography
P. Moskal, A. Gajos, M. Mohammed, J. Chhokar, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, M. Gorgol, J. Goworek, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, S. Niedźwiecki, S. Parzych, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, S. Choudhary, R. Shopa, A. Sienkiewicz, M. Silarski, M. Skurzok, E. Stepien, F. Tayefi, W. Wiślicki
abstract
Charged lepton system symmetry under combined charge, parity, and time-reversal transformation (CPT) remain scarcely tested. Despite stringent quantum-electrodynamic limits, discrepancies in predictions for the electron-positron bound state (positronium atom) motivate further investigation, including fundamental symmetry tests. While CPT noninvariance effects could be manifested in non-vanishing angular correlations between final-state photons and spin of annihilating positronium, measurements were previously limited by the knowledge of the latter. Here, we demonstrate tomographic reconstruction techniques applied to three-photon annihilations of ortho-positronium atoms to estimate their spin polarisation without a magnetic field or polarised positronium source. We use a plastic-scintillator-based positron-emission-tomography scanner to record ortho-positronium (o-Ps) annihilations with a single-event estimation of o-Ps spin and determine the complete spectrum of an angular correlation operator sensitive to CPT-violating effects. We find no violation at the precision level of 10^{-4}, with an over threefold improvement on the previous measurement.
Blue-emitting polystyrene scintillators for plastic scintillation dosimetry
Ł. Kapłon, G. Moskal
abstract
Objectives: Purpose of this research was to find the best blue-emitting fluorescent substance for plastic scintillator used for gamma radiation dosimetry. Scintillator should convert gamma radiation into blue light with high efficiency.
Methods: Plastic scintillators with fixed concentration of various fluorescent additives, called wavelength shifters, absorbing ultraviolet light and emitting blue light were manufactured by radical bulk polymerization of styrene. Light output were measured and compared to the light output of commercial plastic scintillator.
Results: Performed measurements of charge Compton spectra confirmed usefulness of majority of researched substances as wavelength shifters in plastic scintillators with emission maximum at blue range of visible light.
Conclusions: Plastic scintillation dosimeter may be constructed from manufactured polystyrene-based scintillators. Performance of synthesized scintillators is close to commercial polystyrene scintillators.
Simulating NEMA characteristics of the modular total-body J-PET scanner - an economic total-body PET from plastic scintillators
P. Moskal, P. Kowalski, R.Y. Shopa, L. Raczyński, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, P. Kopka, G. Korcyl, N. Krawczyk, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, Sz. Parzych, J. Raj, S. Sharma, S. Shivani, E. Stępień, F. Tayefi, W. Wiślicki
abstract
The purpose of the presented research is the estimation of the performance characteristics of the economic total-body Jagiellonian-PET system (TB-J-PET) constructed from plastic scintillators. The characteristics are estimated according to the NEMANU-2-2018 standards utilizing the GATE package. The simulated detector consists of 24 modules, each built out of 32 plastic scintillator strips
(each with a cross-section of 6 mm times 30 mm and length of 140 or 200 cm) arranged in two layers in regular 24-sided polygon circumscribing a circle with a diameter of 78.6 cm. For the TB-J-PET with an axial field-of-view (AFOV) of 200 cm, a spatial resolution (SRs) of 3.7mm (transversal) and 4.9mm (axial) are achieved. The noise equivalent count rate (NECR) peak of 630 kcps is expected at 30 kBq cc^-1. Activity concentration and the sensitivity at the center amount to 38 cps kBq^-1. The scatter fraction (SF) is estimated to 36.2 %. The values of SF and SR are comparable to those obtained for the state-of-the-art clinical PET scanners and the first total-body tomographs: uExplorer and PennPET.With respect to the standard PET systemswithAFOVin the range from16 to 26 cm, the TBJ-PET is characterized by an increase inNECRapproximately by a factor of 4 and by the increase of the whole-body sensitivity by a factor of 12.6 to 38. The time-of-flight resolution for the TB-J-PETis expected to be at the level ofCRT=240 ps fullwidth at half-maximum. For the TB-J-PETwith an AFOVof 140 cm, an image quality of the reconstructed images of a NEMAIEC phantom was presented with a contrast recovery coefficient and a background variability parameters. The increase of the whole-body sensitivity andNECRestimated for the TB-J-PET with respect to current commercial PETsystems makes the TB-J-PET a promising cost-effective solution for the broad clinical applications of total-body PET scanners. TB-J-PETmay constitutes an economic alternative for the crystal TB-PET scanners, since plastic scintillators are much cheaper than BGO or LYSO crystals and the axial arrangement of the strips significantly reduces the costs of readout electronics and SiPMs.
The J-PET detector - a tool for precision studies of ortho-positronium decays
K. Dulski, S.D. Bass, J. Chhokar, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B.C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K. Klimaszewski, P. Kopka, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, P. Małczak, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński7, J. Raj, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, F. Tayefi, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The J-PET tomograph is constructed from plastic scintillator strips arranged axially in concentric cylindrical layers. It enables investigations of positronium decays by measurement of the time, position, polarization and energy deposited by photons in the scintillators, in contrast to studies conducted so far with crystal and semiconductor based detection systems where the key selection of events is based on the measurement of the photons energies. In this article we show that the J-PET tomography system constructed solely from plastic scintillator detectors is capable of exclusive measurements of the decays of ortho-positronium atoms. We present the first positronium production results and its lifetime distribution measurements. The obtained results prove the capability of the J-PET tomograph for (i) fundamental studies of positronium decays (in particular test of discrete symmetries in purely leptonic systems), (ii) positron annihilation lifetime spectroscopy, as well as (iii) molecular imaging diagnostics and (iv) observation of entanglement
Synchronisation and calibration of the 24-modules J-PET prototype with 300 mm axial field of view
P. Moskal, T. Bednarski, Sz. Niedźwiecki, M. Silarski, E. Czerwiński, T. Kozik, J. Chhokar, M. Bała, C. Curceanu, R. Del Grande, M. Dadgar, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K.Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, L. Raczyński, S. Sharma, Shivani, R. Y. Shopa, M. Skurzok, E. Stępień, W. Wiślicki, B. Zgardzińska
abstract
Research conducted in the framework of the J-PET project aims to develop a cost-effective total-body positron emission tomography scanner. As a first step on the way to construct a full-scale J-PET tomograph from long strips of plastic scintillators, a 24-strip prototype was built and tested. The prototype consists of detection modules arranged axially forming a cylindrical diagnostic chamber with an inner diameter of 360 mm and an axial field-of-view of 300 mm. Promising perspectives for a low-cost construction of a total-body PET scanner are opened due to an axial arrangement of strips of plastic scintillators, which have a small light attenuation, superior timing properties, and the possibility of cost-effective increase of the axial field-of-view. The presented prototype comprises dedicated solely digital front-end electronic circuits and a triggerless data acquisition system which required development of new calibration methods including time, thresholds and gain synchronization. The system and elaborated calibration methods including first results of the 24-module J-PET prototype are presented and discussed. The achieved coincidence resolving time equals to CRT = 490 +- 9 ps. This value can be translated to the position reconstruction accuracy s(Dl) = 18 mm which is fairly position-independent Keywords: positron emission tomography, plastic scintillators, J-PET.
Technical Attenuation Length Measurement of Plastic Scintillator Strips for the Total-Body J-PET Scanner
Ł. Kapłon
abstract
The aim of the performed technical attenuation length measurement is to compare light attenuation of a few commercially available plastic scintillator strips and to select the best scintillator type for the total-body Jagiellonian Positron Emission Tomograph (J-PET) construction. Few models of plastic scintillators obtained from different manufacturers were tested. All strips had the same rectangular cross section and dimensions 6 mm x 24 mm x 1000 mm with all surfaces polished. The light attenuation length was measured by exciting the scintillator strip at different positions with an ultraviolet lamp emitting at 365 nm and reading light signal collected at one side of the strip by a silicon photodiode. Among measured plastic scintillators, EJ-200 possesses the highest technical light attenuation length and is suitable for construction of total-body J-PET scanner.
Performance assessment of the 2gamma positronium imaging with the total-body PET scanners
P. Moskal, D. Kisielewska, Z. Bura, C. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, A. Kamińska, Ł. Kapłon, H. Karimi, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, P. Małczak, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński, J. Raj, A. Ruciński, S. Sharma, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, S. Vandenberghe, W. Wiślicki, B. Zgardzińska
abstract
In living organisms the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511~keV photons. In this article we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include: (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using 2gamma annihilations, and (ii) estimation of the spatial and time resolution of the ortho-positronium image as a function of the coincidence resolving time (CRT) of the scanner. Simulations are conducted assuming that radiopharmaceutical is labelled with 44Sc isotope emitting one positron and one prompt gamma. The image is reconstructed on the basis of triple coincidence events. The ortho-positronium lifetime spectrum is determined for each voxel of the image. Calculations were performed for cases of total-body detectors build of (i) LYSO scintillators as used in the EXPLORER PET, and (ii) plastic scintillators as anticipated for the cost-effective total-body J-PET scanner. To assess the spatial and time resolution the three cases were considered assuming that CRT is equal to 140ps, 50ps and 10ps. The estimated total-body PET sensitivity for the registration and selection of image forming triple coincidences is larger by a factor of 12.2 (for LYSO PET) and by factor of 4.7 (for plastic PET) with respect to the sensitivity for the standard 2gamma imaging by LYSO PET scanners with AFOV=20cm.
Estimating relationship between the Time Over Threshold and energy loss by photons in plastic scintillators used in the J-PET scanner
S. Sharma, J. Chhokar, C. Curceanu, E. Czerwinski, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, N. Gupta-Sharma, R. Del Grande, B. C. Hiesmayr, B. Jasinska, K. Kacprzak, L. Kaplon, H. Karimi, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemien, E. Kubicz, M. Mohammed, Sz. Niedzwiecki, M. Palka, M. Pawlik-Niedzwiecka, L. Raczynski, J. Raj, A. Rucinski, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, E. L. Stepien, W. Wislicki, B. Zgardzinska, P. Moskal
abstract
Time-Over-Threshold (TOT) technique is being used widely due to its implications in developing the multi channel readouts mainly when fast signal processing is required. Using TOT technique as a measure of energy loss instead of charge integration methods significantly reduces the signals readout cost by combining the time and energy information. Therefore, this approach can potentially be used in J-PET tomograph which is build from plastic scintillators characterized by fast light signals. The drawback in adopting this technique is lying in the non-linear correlation between input energy loss and TOT of the signal. The main motivation behind this work is to develop the relationship between TOT and energy loss and validate it with the J-PET tomograph.
The experiment was performed using the 22Na beta emitter source placed in the center of the J-PET tomograph. One can obtain primary photons of two different energies: 511 keV photon from the annihilation of positron (direct annihilation or through the formation of para-Positronim atom or pick-off process of ortho-Positronium atoms), and 1275 keV prompt photon. This allows to study the correlation between TOT values and energy loss for energy range up to 1000 keV. As the photon interacts dominantly via Compton scattering inside the plastic scintillator, there is no direct information of primary photon energy. However, using the J-PET geometry one can measure the scattering angle of the interacting photon. Since, 22Na source emits photons of two different energies, it is required to know unambiguously the energy of incident photons and its corresponding scattering angle for the estimation of energy deposition. In this work, the relationship between Time Over Threshold and energy loss by interacting photons inside the plastic scintillators used in J-PET scanner is established for a energy deposited range 100-1000 keV.
Hit-time and hit-position reconstruction in strips of plastic scintillators using multi-threshold readouts
N. G. Sharma, M. Silarski, J. Chhokar, E. Czerwinski, C. Curceanu, K. Dulski, K. Farbaniec, A. Gajos, R. Del Grande, M. Gorgol, B. C. Hiesmayr, B. Jasinska, K. Kacprzak, L. Kaplon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemien, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedzwiecki, M. Palka, M. Pawlik-Niedzwiecka, L. Raczynski, J. Raj, S. Sharma, S. Shivani, R. Y. Shopa, M. Skurzok, W. Wislicki, B. Zgardzinska, P. Moskal
abstract
In this article a new method for the reconstruction of hit-position and hit-time of photons in long scintillator detectors is investigated. This research is motivated by the recent development of the positron emission tomography scanners based on plastic scintillators. The proposed method constitutes a new way of signal processing in Multi-Voltage-Technique. It is based on the determination of the degree of similarity between the registered signals and the synchronized model signals stored in a library. The library was established for a set of well defined hit-positions along the length of the scintillator. The Mahalanobis distance was used as a measure of similarity between the two compared signals. The method was validated on the experimental data measured using two-strips J-PET prototype with dimensions of 5x9x300 mm. The obtained Time-of-Flight (TOF) and spatial resolutions amount to 325 ps (FWHM) and 25 mm (FWHM), respectively. The TOF resolution was also compared to the results of an analogous study done using Linear Fitting method. The best TOF resolution was obtained with this method at four pre-defined threshold levels which was comparable to the resolution achieved from the Mahalanobis distance at two pre-defined threshold levels. Although the algorithm of Linear Fitting method is much simpler to apply than the Mahalanobis method, the application of the Mahalanobis distance requires a lower number of applied threshold levels and, hence, decreases the costs of electronics used in PET scanner.
Synthesis and Characterization of Plastic Scintillators for the Total-body J-PET Scanner
Ł. Kapłon
abstract
The aim of the research was to develop polystyrene scintillator for use in the novel time-of-flight Jagiellonian Positron Emission Tomography (J-PET) scanner being elaborated for the whole-body imaging. To achieve this goal, polystyrene based plastic scintillators with the different chemical compositions were produced and characterized. Light output, decay time and emission spectra were measured to develop best composition of polystyrene scintillator.
Feasibility study of the positronium imaging with the J-PET tomograph
P. Moskal, D. Kisielewska, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, G. Korcyl, P. Kowalski, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E. Stępień, W. Wiślicki, B. Zgardzińska
abstract
A detection system of the conventional PET tomograph is set-up to record data from e+ e- annihilation into two photons with energy of 511 keV, and it gives information on the density distribution of a radiopharmaceutical in the body of the object. In this paper we explore the possibility of performing the three gamma photons imaging based on ortho- positronium annihilation, as well as the possibility of positronium average lifetime imaging with the J-PET tomograph constructed from plastic scintillators. For this purposes simulations of the ortho-positronium formation and its annihilation into three photons were performed taking into account distributions of photons' momenta as predicted by the theory of quantum electrodynamics and the response of the J-PET tomograph. In order to test the proposed ortho-positronium lifetime image reconstruction method, we concentrate on the decay of the ortho-positronium into three photons and applications of radiopharmaceuticals labeled with isotopes emitting a prompt gamma quantum. The proposed method of imaging is based on the determination of hit-times and hit-positions of registered photons which enables the reconstruction of the time and position of the annihilation point as well as the lifetime of the ortho-positronium on an event-by-event basis. We have simulated the production of the positronium in a cylindrical phantom composed of a set of different materials in which the ortho-positronium lifetime varied from 2 ns to ~2.9 ns, as expected for ortho-positronium created in the human body. The presented reconstruction method for total-body J-PET like detector allows to achieve a mean lifetime resolution of about 40 ps. Recent Positron Annihilation Lifetime Spectroscopy measurements of cancerous and healthy uterine tissues show that this sensitivity may allow to study the morphological changes in cell structures.
A feasibility study of the time reversal violation test based on polarization of annihilation photons from the decay of ortho-Positronium with the J-PET detector
J. Raj, A. Gajos, C. Curceanu, E. Czerwiński, K. Dulski, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, K. Rakoczy, Z. Rudy, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is a novel device being developed at Jagiellonian University in Krakow, Poland based on organic scintillators. J-PET is an axially symmetric and high acceptance scanner that can be used as a multi-purpose detector system. It is well suited to pursue tests of discrete symmetries in decays of positronium in addition to medical
imaging. J-PET enables the measurement of both momenta and the polarization vectors of annihilation photons. The latter is a unique feature of the J-PET detector which allows the study of time reversal symmetry violation operator which can be constructed solely from the annihilation photons momenta before and after the scattering in the detector.
Commissioning of the J-PET detector in view of the positron annihilation lifetime spectroscopy
K. Dulski, C. Curceanu, E. Czerwiński, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET device built from plastic scintillators. It is a multi-purpose detector designed for medical imaging and for studies of properties of positronium atoms in porous matter and in living organisms. In this article we report on the commissioning of the J-PET detector in view of studies of positronium decays. We present results of analysis of the positron lifetime measured in the porous polymer. The obtained results prove that J-PET is capable of performing simultaneous imaging of the density distribution of annihilation points as well as positron annihilation lifetime spectroscopy.
Feasibility study of the time reversal symmetry tests in decay of metastable positronium atoms with the J-PET detector
A. Gajos, C. Curceanu, E. Czerwinski, K. Dulski, M. Gorgol, N. Gupta-Sharma, B.C. Hiesmayr, B. Jasinska, K. Kacprzak, L. Kaplon, D. Kisielewska, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemien, E. Kubicz, M. Mohammed, Sz Niedzwiecki, M. Paalka, M. Pawlik-Niedzwiecka, L. Raczynski, J. Raj, Z. Rudy, S. Sharma, Shivani, R. Shopa, M. Silarski, M. Skurzok, W. Wislicki, B. Zgardzinska, M. Zielinski, P. Moskal
abstract
This article reports on the feasibility of testing of the symmetry under reversal in time in a purely leptonic system constituted by positronium atoms using the J-PET detector. The present state of T symmetry tests is discussed with an emphasis on the scarcely explored sector of leptonic systems. Two possible strategies of searching for manifestations of T violation in non-vanishing angular correlations of final state observables in the decays of metastable triplet states of positronium available with J-PET are proposed and discussed. Results of a pilot measurement with J-PET and assessment of its performance in reconstruction of three-photon decays are shown along with an analysis of its impact on the sensitivity of the detector for the determination of T -violation sensitive observables.
Estimating the NEMA characteristics of the J-PET tomograph using the GATE package
P. Kowalski, W. Wiślicki, R.Y. Shopa, L. Raczyński, K. Klimaszewski, C. Curcenau, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. Hiesmayr, B. Jasińska, Ł. Kapłon, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, S. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, S. Shivani, M. Silarski, M. Skurzok, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel whole-body positron emission tomography (PET) system based on plastic scintillators is
developed by the J-PET Collaboration. It consists of plastic scintillator strips arranged axially in the
form of a cylinder, allowing the cost-effective construction of the total-body PET system. In order to
determine the properties of the scanner prototype and optimize its geometry, advanced computer
simulations were performed using the GATE (Geant4 application for tomographic emission)
software.
The spatial resolution, sensitivity, scatter fraction and noise equivalent count rate were estimated
according to the National Electrical Manufacturers Association norm, as a function of the length
of the tomograph, the number of detection layers, the diameter of the tomographic chamber and
for various types of applied readout. For the single-layer geometry with a diameter of 85 cm, a strip
length of 100 cm, a cross-section of 4 mm × 20 mm and silicon photomultipliers with an additional
layer of wavelength shifter as the readout, the spatial resolution (full width at half maximum) in
the centre of the scanner is equal to 3 mm (radial, tangential) and 6 mm (axial). For the analogous
double-layer geometry with the same readout, diameter and scintillator length, with a strip crosssection
of 7 mm × 20 mm, a noise equivalent count rate peak of 300 kcps was reached at 40 kBq cc?1
activity concentration, the scatter fraction is estimated to be about 35% and the sensitivity at the
centre amounts to 14.9 cps kBq?1. Sensitivity profiles were also determined.
Novel scintillating material 2-(4-styrylphenyl)benzoxazole for the fully digital and MRI compatible J-PET tomograph based on plastic scintillators
A. Wieczorek, K. Dulski, Sz. Niedźwiecki, D. Alfs, P. Białas, C. Curceanu, E. Czerwiński, A. Danel, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Kucharek, M. Mohammed, M. Pawlik-Niedźwiecka, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N. G. Sharma, M. Silarski, T. Uchacz, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel
plastic
scintillator
is developed
for
the
application
in the
digital
positron
emission
tomography
(PET).
The
novelty
of the
concept
lies
in application
of the
2-(4-styrylphenyl)
benzoxazole
as
a wavelength
shifter.
The
substance
has
not
been
used
as
scintillator
dop-
ant
before.
A dopant
shifts
the
scintillation
spectrum
towards
longer
wavelengths
making
it
more
suitable
for
applications
in scintillators
of long
strips
geometry
and
light
detection
with
digital
silicon
photomultipliers.
These
features
open
perspectives
for
the
construction
of the
cost-effective
and
MRI-compatib
le PET
scanner
with
the
large
field
of view.
In this
article
we
present
the
synthesis
method
and
characterize
performance
of the
elaborated
scintillator
by
determining
its
light
emission
spectrum,
light
emission
efficiency,
rising
and
decay
time
of
the
scintillation
pulses
and
resulting
timing
resolution
when
applied
in the
positron
emission
tomography.
The
optimal
concentratio
n of the
novel
wavelength
shifter
was
established
by
maximizing
the
light
output
and
it was
found
to be
0.05
?
for
cuboidal
scintillator
with
dimen-
sions
of 14
mm
x 14
mm
x 20
mm.
J-PET: A New Technology for the Whole-body PET Imaging
S. Niedźwiecki, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B.C. Hiesmayr, B. Jasińska, Ł. Kapłon, D. Kisielewska-Kamińska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R.Y. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET built from plastic scintillators. J-PET prototype consists of 192 detection modules arranged axially in three layers forming a cylindrical diagnostic chamber with the inner diameter of 85 cm and the axial field-of-view of 50 cm. An axial arrangement of long strips of plastic scintillators, their small light attenuation, superior timing properties, and relative ease of the increase of the axial field-of-view opens promising perspectives for the cost effective construction of the whole-body PET scanner, as well as construction of MR and CT compatible PET inserts. Present status of the development of the J-PET tomograph will be presented and discussed.
Determination of the 3gamma Fraction from Positron Annihilation in Mesoporous Materials for Symmetry Violation Experiment with J-PET Scanner
B. Jasińska, M. Gorgol, M. Wiertel, R. Zaleski, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos B. Głowacz, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
Various mesoporous materials were investigated to choose the best material for experiments requiring high yield of long-lived positronium. We found that the fraction of 3? annihilation determined using ?-ray energy spectra and positron annihilation lifetime spectra (PAL) changed from 20% to 25%. The 3? fraction and o-Ps formation probability in the polymer XAD-4 is found to be the largest. Elemental analysis performed using scanning electron microscope (SEM) equipped with energy-dispersive X-ray spectroscope EDS shows high purity of the investigated materials.
Sampling FEE and Trigger-less DAQ for the J-PET Scanner
G. Korcyl, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, B. Jasińska, D. Kamińska Ł. Kapłon, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, K. Stoła, A. Strzelecki, A. Wieczorek, W. Wiślicki, B.K. Zgardzińska, M. Zieliński, P. Moskal
abstract
In this paper, we present a complete Data Acquisition System (DAQ) together with the readout mechanisms for the J-PET tomography scanner. In general, detector readout chain is constructed out of Front-End Electronics (FEE) measurement devices such as Time-to-Digital or Analog-to-Digital Converters (TDCs or ADCs), data collectors and storage. We have developed a system capable for maintaining continuous readout of digitized data without preliminary selection. Such operation mode results in up to 8 Gbps data stream, therefore, it is required to introduce a dedicated module for on-line event building and feature extraction. The Central Controller Module, equipped with Xilinx Zynq SoC and 16 optical transceivers, serves as such true real time computing facility. Our solution for the continuous data recording (trigger-less) is a novel approach in such detector systems and assures that most of the information is preserved on the storage for further, high-level processing. Signal discrimination applies a unique method of using LVDS buffers located in the FPGA fabric.
Application of the compress sensing theory for improvement of the TOF resolution in a novel J-PET instrument
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, N. Gupta-Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
Trilateration-based reconstruction of ortho-positronium decays into three photons with the J-PET detector
A. Gajos, D. Kamińska, E. Czerwiński, D. Alfs, T. Bednarski, P. Białas, B. Głowacz, M. Gorgol, B. Jasińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
This work reports on a new reconstruction algorithm allowing us to reconstruct the decays of ortho-positronium atoms into three photons using the places and times of photons recorded in the detector. The method is based on trilateration and allows for a simultaneous reconstruction of both location and time of the decay. Results of resolution tests of the new reconstruction in the J-PET detector based on Monte Carlo simulations are presented, which yield a spatial resolution at the level of 2 cm (FWHM) for X and Y and at the level of 1 cm (FWHM) for Z available with the present resolution of J-PET after application of a kinematic fit. Prospects of employment of this method for studying angular correlations of photons in decays of polarized ortho-positronia for the needs of tests of CP and CPT discrete symmetries are also discussed. The new reconstruction method allows for discrimination of background from random three-photon coincidences as well as for application of a novel method for determination of the linear polarization of ortho-positronium atoms, which is also introduced in this work.
Time resolution of the plastic scintillator strips with matrix photomultiplier readout for J-PET tomograph
P. Moskal, O. Rundel, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, K. Giergiel, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, A. Słomski, M. Silarski, A. Strzelecki, A. Wieczorek, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Recent tests of a single module of the Jagiellonian Positron Emission
Tomography system (J-PET) consisting of 30 cm long plastic scintillator
strips have proven its applicability for the detection of annihilation quanta
(0.511 MeV) with a coincidence resolving time (CRT) of 0.266 ns. The
achieved resolution is almost by a factor of two better with respect to the
current TOF-PET detectors and it can still be improved since, as it is shown
in this article, the intrinsic limit of time resolution for the determination of
time of the interaction of 0.511 MeV gamma quanta in plastic scintillators
is much lower. As the major point of the article, a method allowing to
record timestamps of several photons, at two ends of the scintillator strip,
by means of matrix of silicon photomultipliers (SiPM) is introduced. As a
result of simulations, conducted with the number of SiPM varying from 4 to 42, it is shown that the improvement of timing resolution saturates with
the growing number of photomultipliers, and that the 2×5 configuration at
two ends allowing to read twenty timestamps, constitutes an optimal solution.
The conducted simulations accounted for the emission time distribution,
photon transport and absorption inside the scintillator, as well as quantum
efficiency and transit time spread of photosensors, and were checked based on
the experimental results. Application of the 2×5 matrix of SiPM allows for
achieving the coincidence resolving time in positron emission tomography of
0.170 ns for 15 cm axial field-of-view (AFOV) and 0.365 ns for 100 cm
AFOV. The results open perspectives for construction of a cost-effective TOFPET
scanner with significantly better TOF resolution and larger AFOV with
respect to the current TOF-PET modalities.
Searches for discrete symmetries violation in ortho-positronium decay using the J-PET detector
D. Kamińska, A. Gajos, E. Czerwiński, T. Bednarski, P. Białas, M. Gorgol, B. Jasińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
In this paper, we present prospects for using the Jagiellonian positron emission tomograph (J-PET)
detector to search for discrete symmetries violations in a purely leptonic system of the positronium atom. We
discuss tests of CP and CPT symmetries by means of ortho-positronium decays into three photons. No zero
expectation values for chosen correlations between ortho-positronium spin and momentum vectors of photons
would imply the existence of physics phenomena beyond the standard model. Previous measurements resulted
in violation amplitude parameters for CP and CPT symmetries consistent with zero, with an uncertainty of
about 10?3. The J-PET detector allows to determine those values with better precision, thanks to the unique
time and angular resolution combined with a high geometrical acceptance. Achieving the aforementioned is possible
because of the application of polymer scintillators instead of crystals as detectors of annihilation quanta.
Studies of unicellular microorganisms Saccharomyces cerevisiae by means of positron annihilation lifetime spectroscopy
E. Kubicz, B. Jasińska, B. Zgardzińska, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rajfur, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, P. Moskal
abstract
Results of positron annihilation lifetime spectroscopy (PALS) and microscopic studies on simple microorganisms,
brewing yeasts, are presented. Lifetime of ortho-positronium (o-Ps) were found to change from 2.4 to 2.9 ns
(longer-lived component) for lyophilized and aqueous yeasts, respectively. Also hygroscopicity of yeasts in time was
examined, allowing to check how water ? the main component of the cell ? affects PALS parameters, thus lifetime
of o-Ps were found to change from 1.2 to 1.4 ns (shorter-lived component) for the dried yeasts. The time suffi cient
to hydrate the cells was found below 10 hours. In the presence of liquid water, an indication of reorganization of
yeast in the molecular scale was observed. Microscopic images of the lyophilized, dried, and wet yeasts with best
possible resolution were obtained using inverted microscopy (IM) and environmental scanning electron microscopy
(ESEM) methods. As a result, visible changes to the surface of the cell me mbrane were observed in ESEM images.
Reconstruction of hit time and hit position of annihilation quanta in the J-PET detector usi ng the Mahalanobis distance
N. G. Sharma, M. Silarski, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
The J-PET detector being developed at Jagiellonian University, is a Positron Emission Tomograph composed of the long strips of polymer scintillators. At the same time it is a detector system which will be used for studies of the decays of positronium atoms. The shape of photomultiplier signals depends on the hit-time and hit-position of the gamma quantum. In order to take advantage of this fact a dedicated sampling front-end electronics which enables to sample signals in voltage domain with the time precision of about 20 ps and novel reconstruction method based on the comparison of examined signal with the model signals stored in the library has been developed. As a measure of the similarity we use the Mahalanobis distance. The achievable position and time-resolution depends on number and values of the threshold levels at which the signal is sampled. A reconstruction method, as well as preliminary results are presented and discussed.
PALS investigations of free volumes thermal expansion of J-PET plastic scintillator synthesized in polystyrene matrix
A. Wieczorek, B. Zgardzińska, B. Jasińska, M. Gorgol, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, W. Wiślicki, M. Zieliński, P. Moskal
abstract
The polystyrene dopped with 2,5-diphenyloxazole as a primary fluor and 2-(4-styrylphenyl)benzoxazole as a wavelength shifter, prepared as a plastic scintillator was investigated using positronium probe in wide range of temperatures from 123 to 423 K. Three structural transitions at 260 K, 283 K and 370 K were found in the material. In the o-Ps intensity dependence on temperature, the significant hysteresis is observed. Heated to 370 K, the material exhibits the o-Ps intensity variations in time.
Processing optimization with parallel computing for the J-PET scanner
W. Krzemień, M. Bała, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, K. Stola, A. Strzelecki, D. Trybek, Anna Wieczorek, W. Wiślicki, M. Zieliński, B. K. Zgardzińska, P. Moskal
abstract
The Jagiellonian-PET (J-PET) collaboration is developing a prototype TOF-PET detector based on long polymer scintillators. This novel approach exploits the excellent time properties of the plastic scintillators, which permit very precise time measurements. The very fast, FPGA-based front-end electronics and the data acquisition system, as well as, low- and high-level reconstruction algorithms were specially developed to be used with the J-PET scanner. The TOF-PET data processing and reconstruction are time and resource demanding operations, especially in case of a large acceptance detector, which works in triggerless data acquisition mode. In this article, we discuss the parallel computing methods applied to optimize the data processing for the J-PET detector. We begin with general concepts of parallel computing and then we discuss several applications of those techniques in the J-PET data processing.
Multiple Scattering and Accidental Coincidences in the J-PET Detector Simulated Using GATE Package
P. Kowalski, P. Moskal, W. Wislicki, L. Raczynski, T. Bednarski, P. Bialas, J. Bulka, E. Czerwinski, A. Gajos, A. Gruntowski, D. Kaminska, L. Kaplon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemien, E. Kubicz, S. Niedzwiecki, M. Palka, Z. Rudy, P. Salabura, NG. Sharma, M. Silarski, A. Slomski, J. Smyrski, A. Strzelecki, A. Wieczorek, I. Wochlik, M. Zielinski, N. Zon
abstract
Novel positron emission tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.
A pilot study of the novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter
A. Wieczorek, P. Moskal, Sz. Niedźwiecki, T. Bednarski, P. Białas, E. Czerwiński, A. Danel, A. Gajos, A. Gruntowski, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, T. Uchacz, W. Wiślicki, M. Zieliński, N. Zoń
abstract
For the first time a molecule of 2-(4-styrylphenyl)benzoxazole containing benzoxazole and stilbene groups is applied as a scintillator dopant acting as a wavelength shifter. In this article a light yield of the plastic scintillator, prepared from styrene doped with 2 wt% of 2,5-diphenylbenzoxazole and 0.03 wt% of 2-(4-styrylphenyl)benzoxazole, is determined to be as large as 60% ? 2% of the anthracene light output. There is a potential to improve this value in the future by the optimization of the additives concentrations.
Compressive sensing of signals generated in plastic scintillators in a novel J-PET instrument
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
The J-PET scanner, which allows for single bed imaging of the whole human body, is currently under development at the Jagiellonian University. The discussed detector offers improvement of the Time of Flight (TOF) resolution due to the use of fast plastic scintillators and dedicated electronics allowing for sampling in the voltage domain of signals with durations of few nanoseconds. In this paper we show that recovery of the whole signal, based on only a few samples, is possible. In order to do that, we incorporate the training signals into the Tikhonov regularization framework and we perform the Principal Component Analysis decomposition, which is well known for its compaction properties. The method yields a simple closed form analytical solution that does not require iterative processing. Moreover, from the Bayes theory the properties of regularized solution, especially its covariance matrix, may be easily derived. This is the key to introduce and prove the formula for calculations of the signal recovery error. In this paper we show that an average recovery error is approximately inversely proportional to the number of acquired samples.
GPU accelerated image reconstruction in a two-strip J-PET tomograph
P. Białas, J. Kowal, A. Strzelecki, T. Bednarski, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, P. Moskal, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Wieczorek, W. Wiślicki, M. Zieliński, N. Zoń
abstract
We present a fast GPU implementation of the image reconstruction routine, for a novel two strip PET detector that relies solely on the time of flight measurements.
A novel method for the line-of-response and time-of-flight reconstruction in TOF-PET detectors based on a library of synchronized model signals
P. Moskal, N. Zoń, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński
abstract
A novel method of hit time and hit position reconstruction in scintillator detectors is described. The method is based on comparison of detector signals with results stored in a library of synchronized model signals registered for a set of well-defined positions of scintillation points. The hit position is reconstructed as the one corresponding to the signal from the library which is most similar to the measurement signal. The time of the interaction is determined as a relative time between the measured signal and the most similar one in the library. A degree of similarity of measured and model signals is defined as the distance between points representing the measurement- and model-signal in the multi-dimensional measurement space. Novelty of the method lies also in the proposed way of synchronization of model signals enabling direct determination of the difference between time-of-flights (TOF) of annihilation quanta from the annihilation point to the detectors. The introduced method was validated using experimental data obtained by means of the double strip prototype of the J-PET detector and 22Na sodium isotope as a source of annihilation gamma quanta.The detector was built out from plastic scintillator strips with dimensions of 5 mm x 19 mm x 300 mm, optically connected at both sides to photomultipliers,from which signals were sampled by means of the Serial Data Analyzer.Using the introduced method, the spatial and TOF resolution of about 1.3 cm (?) and 125 ps (?) were established, respectively.
Test of a single module of the J-PET scanner based on plastic scintillators
P. Moskal, S. Niedzwiecki, T. Bednarski, E. Czerwinski, L. Kaplon, E. Kubicz, I. Moskal, M. Pawlik-Niedzwiecka, NG. Sharma, M. Silarski, M. Zielinski, N. Zon, P. Bialas, A. Gajos, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemien, M. Molenda, M. Palka, L. Raczynski, Z. Rudy, P. Salabura, A. Slomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wislicki
abstract
A Time of Flight Positron Emission Tomography scanner based on plastic scintillators is being developed at the Jagiellonian University by the J-PET collaboration. The main challenge of the conducted research lies in the elaboration of a method allowing application of plastic scintillators for the detection of low energy gamma quanta. In this paper we report on tests of a single detection module built out from the BC-420 plastic scintillator strip (with dimensions of 5 x 19 x 300 mm(3)) read out at two ends by Hamamatsu R5320 photomultipliers. The measurements were performed using collimated beam of annihilation quanta from the Ge-68 isotope and applying the Serial Data Analyzer (Lecroy SDA6000A) which enabled sampling of signals with 50 ps intervals. The time resolution of the prototype module was established to be better than 80 ps (sigma) for a single level discrimination. The spatial resolution of the determination of the hit position along the strip was determined to be about 0.93 cm (sigma) for the annihilation quanta. The fractional energy resolution for the energy E deposited by the annihilation quanta via the Compton scattering amounts to sigma(E)/E approximate to 0.044/root E(MeV) and corresponds to the (sigma(E)/E of 7.5% at the Compton edge. (C) 2014 Elsevier B.V. All rights reserved.
Test of a single module of the J-PET scanner based on plastic scintillators
P. Moskal, Sz. Niedźwiecki, T. Bednarski, E. Czerwiński, Ł. Kapłon, E. Kubicz, I. Moskal, M. Pawlik-Niedźwiecka, N.G. Sharma, M. Silarski, M. Zieliński, N. Zoń, P. Białas, A. Gajos, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, M. Pałka, L. Raczyński, Z. Rudy, P. Salabura, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki
abstract
Time of Flight Positron Emission Tomography scanner based on plastic scintillators is being developed at the Jagiellonian University by the J-PET collaboration. The main challenge of the conducted research lies in the elaboration of a method allowing application of plastic scintillators for the detection of low energy gamma quanta. In this article we report on tests of a single detection module built out from BC-420 plastic scintillator strip (with dimensions of 5x19x300mm^3) read out at two ends by Hamamatsu R5320 photomultipliers. The measurements were performed using collimated beam of annihilation quanta from the 68Ge isotope and applying the Serial Data Analyzer (Lecroy SDA6000A) which enabled sampling of signals with 50ps intervals. The time resolution of the prototype module was established to be better than 80ps (sigma) for a single level discrimination. The spatial resolution of the determination of the hit position along the strip was determined to be about 0.93cm (sigma) for the annihilation quanta. The fractional energy resolution for the energy E deposited by the annihilation quanta via the Compton scattering amounts to sigma(E)/E = 0.044/sqrt(E[MeV]) and corresponds to the sigma(E)/E of 7.5% at the Compton edge.
Novel method for hit-position reconstruction using voltage signals in plastic scintillators and its application to Positron Emission Tomography
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic scintillators which would allow for single bed imaging of the whole human body. This paper describes a novel method of hit-position reconstruction based on sampled signals and an example of an application of the method for a single module with a 30 cm long plastic strip, read out on both ends by Hamamatsu R4998 photomultipliers. The sampling scheme to generate a vector with samples of a PET event waveform with respect to four user-defined amplitudes is introduced. The experimental setup provides irradiation of a chosen position in the plastic scintillator strip with an annihilation gamma quanta of energy 511 keV. The statistical test for a multivariate normal (MVN) distribution of measured vectors at a given position is developed, and it is shown that signals sampled at four thresholds in a voltage domain are approximately normally distributed variables. With the presented method of a vector analysis made out of waveform samples acquired with four thresholds, we obtain a spatial resolution of about 1 cm and a timing resolution of about 80 ps (sigma).
Computing support for advanced medical data analysis and imaging
W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, S. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
We discuss computing issues for data analysis and image reconstruction of PET-TOF medical scanner or other medical scanning devices producing large volumes of data. Service architecture based on the grid and cloud concepts for distributed processing is proposed and critically discussed.
A novel method based solely on FPGA units enabling measurement of time and charge of analog signals in Positron Emission Tomography
M. Pałka, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article presents a novel technique for precise measurement of time and charge based solely on FPGA (Field Programmable Gate Array) device and few satellite discrete electronic components used in Positron Emission Tomography (PET). Described approach simplifies electronic circuits, reduces the power consumption, lowers costs, merges front-end electronics with digital electronics and also makes more compact final design. Furthermore, it allows to measure time when analog signals cross a reference voltage at different threshold levels with a very high precision of ? 10ps (rms) and thus enables sampling of signals in a voltage domain.
A novel method for calibration and monitoring of time synchronization of TOF-PET scanners by means of cosmic rays
M. Silarski, E. Czerwiński, T. Bednarski, P. Moskal, P. Białas, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
All of the present methods for calibration and monitoring of TOF-PET scanner detectors utilize radioactive isotopes such as e.g. 22Na or 68Ge, which are placed or rotate inside the scanner. In this article we describe a novel method based on the cosmic rays application to the PET calibration and monitoring methods. The concept allows to overcome many of the drawbacks of the present methods and it is well suited for newly developed TOF-PET scanners with a large longitudinal field of view. The method enables also monitoring of the quality of the scintillator materials and in general allows for the continuous quality assurance of the PET detector performance.
3D PET image reconstruction based on the maximum likelihood estimation method (MLEM) algorithm
A. Słomski, Z. Rudy, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, P. Salabura, N. G. Sharma, M. Silarski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
A positron emission tomography (PET) scan does not measure an image directly. Instead, a PET scan measures a sinogram at the boundary of the field-of-view that consists of measurements of the sums of all the counts along the lines connecting the two detectors. Because there is a multitude of detectors built in a typical PET structure, there are many possible detector pairs that pertain to the measurement. The problem is how to turn this measurement into an image (this is called imaging). Significant improvement in PET image quality was achieved with the introduction of iterative reconstruction techniques. This was realized approximately 20 years ago (with the advent of new powerful computing processors). However, three-dimensional imaging still remains a challenge. The purpose of the image reconstruction algorithm is to process this imperfect count data for a large number (many millions) of lines of response and millions of detected photons to produce an image showing the distribution of the labeled molecules in space.
Trigger-less and reconfigurable data acquisition system for positron emission tomography
G. Korcyl, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article is focused on data acquisition system (DAQ) designed especially to be used in positron emission tomography (PET) or single-photon emission computed tomography. The system allows for continuous registration of analog signals during measurement. It has been designed to optimize registration and processing of the information carried by signals from the detector system in PET scanner. The processing does not require any rejection of data with a trigger system. The proposed system possesses also an ability to implement various data analysis algorithms that can be performed in real time during data collection.
Determination of the map of efficiency of the Jagiellonian Positron Emission Tomograph (J-PET) detector with the GATE package
P. Kowalski, L. Raczyński, T. Bednarski, P. Białas, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
A novel PET detector consisting of strips of polymer scintillators is being developed by the J-PET Collaboration. The map of efficiency and the map of geometrical acceptance of the 2-strip J-PET scanner are presented. Map of efficiency was determined using the Monte Carlo simulation software GATE based on GEANT4. Both maps were compared using method based on the chi2 test.
Plastic scintillators for positron emission tomography obtained by the bulk polymerization method
Ł. Kapłon, A. Kochanowski, M. Molenda, P. Moskal, A. Wieczorek, T. Bednarski, P. Białas, E. Czerwiński, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This paper describes three methods regarding the production of plastic scintillators. One method appears to be suitable for the manufacturing of plastic scintillators, revealing properties which fulfill the requirements of novel positron emission tomography scanners based on plastic scintillators. The key parameters of the manufacturing process are determined and discussed.
J-PET analysis framework for the prototype TOF-PET detector
W. Krzemień, M. Silarski, K. Stola, D. Trybek, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
Novel TOF-PET scanner solutions demand, apart from the state of the art detectors, software for fast processing of the gathered data, monitoring of the whole scanner and reconstruction of the PET image. In this article we present an analysis framework for the novel STRIP-PET scanner developed by the J-PET collaboration in the Institute of Physics of the Jagiellonian University. This software is based on the ROOT package used in many particle physics experiments.
Database and data structure for the novel TOF-PET detector developed for J-PET project
E. Czerwiński, M. Zieliński, T. Bednarski, P. Białas, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W.Wiślicki, N. Zoń
abstract
The complexity of the hardware and the amount of data collected during the PET imaging process require application of modern methods of efficient data organization and processing. In this article we will discuss the data structures and the flow of collected data from the novel TOF-PET medical scanner which is being developed at the Jagiellonian University. The developed data format reflects: registration process of the gamma quanta emitted from positron-electron annihilation, Front-End Electronic (FEE) structure and required input information for the image reconstruction. In addition, the system database fulfills possible demands of the evolving J-PET project.
Calibration of photomultipliers gain used in the J-PET detector
T. Bednarski, E. Czerwiński, P. Moskal, P. Białas, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Photomultipliers are commonly used in commercial PET scanner as devices which convert light produced in scintillator by gamma quanta from positron-electron annihilation into electrical signal. For proper analysis of obtained electrical signal, a photomultiplier gain curve must be known, since gain can be significantly different even between photomultipliers of the same model. In this article we describe single photoelectron method used for photomultipliers calibration applied for J-PET scanner, a novel PET detector being developed at the Jagiellonian University. Description of calibration method, an example of calibration curve and gain of few R4998 Hamamatsu photomultipliers are presented.
List-mode reconstruction in 2D strip PET
P. Białas, J. Kowal, A. Strzelecki, T. Bednarski, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, P. Moskal, S. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Using a theory of list-mode maximum likelihood
expectation-maximization (MLEM) algorithm, in this contribution,
we present a derivation of the system response
kernel for a novel positron emission tomography (PET)
detector based on plastic scintillators.
Simulations of gamma quanta scattering in a single module of the J-PET detector
K. Szymański, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, P. Witkowski, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article describes simulations of scattering of annihilation gamma quanta in a strip of plastic scintillator. Such strips constitute basic detection modules in a newly proposed Positron Emission Tomography which utilizes plastic scintillators instead of inorganic crystals. An algorithm simulating chain of Compton scatterings was elaborated and series of simulations have been conducted for the scintillator strip with the cross section of 5 mm x 19 mm. Obtained results indicate that secondary interactions occur only in the case of about 8% of events and out of them only 25% take place in the distance larger than 0.5 cm from the primary interaction. It was also established that light signals produced at primary and secondary interactions overlap with the delay which distribution is characterized by FWHM of about 40 ps.
Application of WLS strips for position determination in Strip PET tomograph based on plastic scintillators
J. Smyrski, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
A method of determination of a gamma quantum absorption point in a plastic scintillator block using a matrix of wavelength-shifting (WLS) strips is proposed. Application of this method for improvement of position resolution in newly proposed PET detectors based on plastic scintillators is presented. The method enables to reduce parallax errors in reconstruction of images which occurs in the presently used Positron Emission Tomography scanners.
TOF-PET detector concept based on organic scintillators
P. Moskal, T. Bednarski, P. Białas, M. Ciszewska, E. Czerwiński, A. Heczko, M. Kajetanowicz, Ł. Kapłon, A. Kochanowski, G. Konopka-Cupiał, G. Korcyl, W. Krzemień, K. Łojek, J. Majewski, W. Migdał, M. Molenda, S. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, M. Silarski, A. Słomski, J. Smyrski, J. Zdebik, M. Zieliński
abstract
In this contribution we present a new concept of the large acceptance detector systems based on organic scintillators which may allow for simultaneous diagnostic of large fraction of the human body. Novelty of the concept lies in employing large blocks of polymer scintillators instead of crystals as detectors of annihilation quanta, and in using predominantly the timing of signals instead of their amplitudes.
Strip-PET: a novel detector concept for the TOF-PET scanner
P. Moskal, T. Bednarski, P. Białas, M. Ciszewska, E. Czerwiński, A. Heczko, M. Kajetanowicz, Ł. Kapłon, A. Kochanowski, G. Konopka-Cupiał, G. Korcyl, W. Krzemień, K. Łojek, J. Majewski, W. Migdał, M. Molenda, S. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, M. Silarski, A. Słomski, J. Smyrski, J. Zdebik, M. Zieliński
abstract
We briefly present a design of a new PET scanner based on
strips of polymer scintillators arranged in a barrel constituting
a large acceptance detector. The solution proposed is based on
the superior timing properties of the polymer scintillators. The
position and time of the reaction of the gamma quanta in the
detector material will be determined based on the time of arrival
of light signals to the edges of the scintillator strips.
Double isotope studies using mouse phantom with J-PET
Ermias Y. Beyene1, 2, 3, Bartosz Leszczynski2, 3, Lukasz Kaplon2, 3, Pawel Moskal2, 3 and Ewa Stepien 2, 3 on behalf of J-PET collaboration
abstract
Conventional Positron Emission Tomography works based on the emission of positrons from the radiotracers and annihilation by the electrons emitting back-to-back gammas [1, 2, 3]. Double tracer PET imaging is a way of using two
tracers, which could be done sequentially or at the same time. It has several advantages: it supplies better information and can track multiple biological molecules [4, 5]. We used a mouse phantom to utilize double-isotope studies with J-
PET. The phantom was modeled from the CT image acquired with the Bruker Skyscan 1278 at a resolution of 50 ?m at the Medical Physics Department, Jagiellonian University. The study was done with a combination of 18FDG with 68Ga
(3.20 MBq), 44Sc (2.05 MBq), 55Co (2.01 MBq), and 52Mn (2.1 MBq), where 18FDG was injected into the head in all the measurements, while the 2? + ?p emitters (68Ga, 44Sc, 55Co, and 52Mn) were injected into the kidney. The 18FDG was
purchased from the Voxel company in Krakow, while the 44Sc and 55Co were produced in the Heavy Ion Collider in Warsaw. 52Mn was produced in the Hevesy Laboratory at the Technical University of Denmark (DTU). Isotopes were
injected into the phantom, data were collected, and then events were selected for both the 2? and 2? + ?p coincidences. Events were filtered for the reconstruction; the event selection step is a way of suppressing the background and
enhancing the true signal from the electron-positron annihilation with or without deexcitations; then images were reconstructed to determine the location of the isotopes. The histograms for both coincidence scenarios for each pair of
measurements are merged in one canvas, showing the variations in the shape of the used isotopes in the studies. The reconstructed images show distinct images both in the head and in the kidney. In the case of double coincidences,
where both isotopes are contributing, two dots are visible, and in the case of triples, while the 2? + ?p is contributing, one point-like image is visible. The subtracted image based on the relative efficiency of the two coincidences shows the
reconstructed image from the pure ?+ isotope; as a result, only a dot is visible.
Double isotope studies using mouse phantom with J-PET
Ermias Y. Beyene, Bartosz Leszczynski, Lukasz Kaplon, Pawel Moskal and Ewa Stepien on behalf of J-PET collaboration
abstract
Conventional Positron Emission Tomography works based on the emission of positrons from the radiotracers and annihilation by the electrons emitting back-to-back gammas [1, 2, 3]. Double tracer PET imaging is a way of using two
tracers, which could be done sequentially or at the same time. It has several advantages: it supplies better information and can track multiple biological molecules [4, 5]. We used a mouse phantom to utilize double-isotope studies with J-
PET. The phantom was modeled from the CT image acquired with the Bruker Skyscan 1278 at a resolution of 50 ?m at the Medical Physics Department, Jagiellonian University. The study was done with a combination of 18 FDG with 68 Ga
(3.20 MBq), 44 Sc (2.05 MBq), 55 Co (2.01 MBq), and 52 Mn (2.1 MBq), where 18 FDG was injected into the head in all the measurements, while the 2? + ?p emitters ( 68 Ga, 44 Sc, 55 Co, and 52 Mn) were injected into the kidney. The 18 FDG was
purchased from the Voxel company in Krakow, while the 44 Sc and 55 Co were produced in the Heavy Ion Collider in Warsaw. 52 Mn was produced in the Hevesy Laboratory at the Technical University of Denmark (DTU). Isotopes were
injected into the phantom, data were collected, and then events were selected for both the 2? and 2? + ?p coincidences. Events were filtered for the reconstruction; the event selection step is a way of suppressing the background and
enhancing the true signal from the electron-positron annihilation with or without deexcitations; then images were reconstructed to determine the location of the isotopes. The histograms for both coincidence scenarios for each pair of
measurements are merged in one canvas, showing the variations in the shape of the used isotopes in the studies. The reconstructed images show distinct images both in the head and in the kidney. In the case of double coincidences,
where both isotopes are contributing, two dots are visible, and in the case of triples, while the 2? + ?p is contributing, one point-like image is visible. The subtracted image based on the relative efficiency of the two coincidences shows the
reconstructed image from the pure ? + isotope; as a result, only a dot is visible.
