A Conjugate Bayesian Framework for Fast 3D Positronium Lifetime Estimation with a Partial System Matrix
Berkin Uluutku, Giulianno Gasparato, Manish Das, Jarosław Choiński, Anand Pandey, Sushil Sharma, Paweł Moskal, Ewa Stępień, Chien-Min Kao, Hsin-Hsiung Huang
abstract
Background: Positronium lifetime imaging extends conventional positron emission tomography by using the time interval between positron emission and annihilation as an additional contrast mechanism. Voxel-wise lifetime estimation in fully three-dimensional settings is computationally difficult because the number of feasible detector-time channels grows rapidly, whereas only a small subset is observed in practice. We developed a scalable statistical framework for three-dimensional positronium lifetime estimation based on a time-of-flight-aware partial system matrix restricted to observed detector-time channels, combined with posterior event-to-voxel weighting and a conjugate Gamma--Exponential update for closed-form voxel-wise effective-rate estimation.
Results: Restricting the forward model to observed detector-time channels reduced memory and computational requirements while preserving the Poisson data model for retained detected triple coincidences. In simulated data with 4056 voxels, the analytic Bayesian estimator required 2.76 s versus 74.46 s for 10 L-BFGS-B iterations on the same CPU while accurately recovering the effective-rate map. In a triple-coincidence dataset acquired with a J-PET prototype scanner and a NEMA image-quality phantom, a 234 375-voxel effective-rate map was estimated in approximately 3 s from about 3.64×105 retained events.
Conclusions: Restricting the system matrix to observed detector-time channels makes fully three-dimensional positronium lifetime estimation computationally practical for sparse triple-coincidence data. The proposed posterior-weighted conjugate update provides a fast and stable single-component surrogate estimator of voxel-wise effective lifetime for large-scale three-dimensional positronium lifetime imaging.
Monte Carlo-Based Scatter Correction for the Plastic Based Modular PET Scanner J-PET
R. Bayerlein†, M. Das†, S. Sharma, R. D. Badawi, E. Y. Beyene, N. Chug, C. Curceanu, E. Czerwiński, K. V. Eliyan, J. Hajduga, A. Hubalewska-Dydejczyk, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, K. Kubat, S. K. Kundu, A. K. Venadan, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, M. Opalińska, P. Pandey, A. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, B. A. Spencer, A. Sowa-Staszczak, M. Skurzok, T. Szumlak, S. Tiwari, P. Tanty, K. T. Ardebili, E. Ł. Stępień, and P. Moskał.
†These authors contributed equally to this work.
abstract
First Positronium Imaging Using 44Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom
Manish Das, Sushil Sharma, Ermias Yitayew Beyene, Aleksander Bilewicz, Jarosław Choiński, Neha Chug, Catalina Curceanu, Eryk Czerwiński, Kavya Valsan Eliyan, Jakub Hajduga, Sharareh Jalali, Krzysztof Kacprzak, Tevfik Kaplanoglu, Łukasz Kapłon, Kamila Kasperska, Aleksander Khreptak, Grzegorz Korcyl, Tomasz Kozik, Karol Kubat, Deepak Kumar, Anoop Kunimmal Venadan, Edward Lisowski, Filip Lisowski, Justyna Medrala Sowa, Simbarashe Moyo, Wiktor Mryka, Szymon Niedźwiecki, Piyush Pandey, Szymon Parzych, Alessio Porcelli, Bartłomiej Rachwał, Elena Perez del Rio, Martin Rädler, Axel Rominger, Kuangyu Shi, Magdalena Skurzok, Anna Stolarz, Tomasz Szumlak, Pooja Tanty, Keyvan Tayefi Ardebili, Satyam Tiwari, Rafał Walczak, Ewa Ł. Stępień, Paweł Moskal
abstract
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph?the first plastic scintillators-based PET scanner.
First Positronium Lifetime Imaging using 52Mn and 55Co with a plastic-based PET scanner
M. Das, S. Sharma, E. Y. Beyene, A. Bilewicz, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, J. Hajduga, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, S. Kumar Kundu, A. Kunimmal Venadan, E. Lisowski, F. Lisowski, J. Medrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, A. Pandey, P. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, N. Rathod, N. Razzaq, A. Rominger, K. Shi, M. Skurzok, M. Słotwiński, A. Stolarz, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, K. Valsan Eliyan, R. Walczak, E. Ł. Stępień, P. Moskal
abstract
This study demonstrates applicability of 52Mn and 55Co radionuclides for positronium imaging. Positronium Lifetime Imaging
(PLI) extends positron emission tomography by using the lifetime of positronium atoms as a probe of tissue molecular
architecture. However, its practical use requires ?+ emitters that also provide an additional prompt ? ray to mark the positron creation time. In this work, we report the first PLI measurements performed with 52Mn and 55Co using the modular J-PET. Four samples were studied in each experiment: two Certified Reference Materials (polycarbonate and fused silica) and two
human tissues (cardiac myxoma and adipose). The selection of PLI events was based on the registration of two 511 keV
annihilation photons and one prompt gamma in triple coincidence. From the resulting lifetime spectra we extracted the mean
ortho-positronium lifetime ?oPs and the mean positron lifetime ?Tmean for each sample. The measured values of ?oPs in
polycarbonate using both isotopes matches well with the certified reference values. Furthermore, 55Co reproduced identical
results for fused-silica measurements at their respective uncertainty levels. In contrast, measurements with 52Mn in fused silica show a minor deviation, which could be caused by the Parafilm spacer. In myxoma and adipose tissue, the reduced ?oPs values are mainly linked to the long storage history of the samples rather than to the choice of isotope. Comparing peak-to-background ratios and spectral purity, 55Co provides cleaner PLI data under the same experimental conditions. Although 52Mn offers a longer half-life and a multi gamma cascade enhancing ?+ + ? coincidences, but at the expense of higher background. In this study, we demonstrate that the applied selection criteria on the data measured with the modular J-PET can be used for PLI studies even with radionuclides with complex decay patterns.
First ex-vivo positronium imaging of tissues with modular J-PET scanner using 44Sc radionuclide
K. Kubat, M. Das, S. Sharma, E. Y. Beyene, A. Bilewicz, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, J. Hajduga, S. Jalali, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, D. Kumar, S. Kumar Kundu, A. Kunimmal-Venadan, B. Leszczyński, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, A. Pandey, P. Pandey, S. Parzych, A. Porcelli, B. Rachwał, M. Rädler, M. Skurzok, A. Stolarz, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, K. Valsan Eliyan, R. Walczak, P. Moskal, E. Ł. Stępień
abstract
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the 44Sc radionuclide. The 44Sc isotope was produced via the 44Ca(p, n)44Sc nuclear reaction and used to perform positronium imaging of phantom composed of human adipose tissue, cardiac myxoma tissue, thrombi blood clot, and also porous polymer XAD4, and a certified reference material (CRM) made from fused silica. The experiment demonstrates the suitability of 44Sc as a positron source for positronium imaging. The performance of J-PET for positronium imaging with 44Sc was validated by proper reconstruction of the mean orthopositronium lifetime for CRM material and XAD-4 polymer. The mean ortho-positronium (oPs) lifetimes determined for adipose tissue, cardiac myxoma tissues and thrombi were consistent with results of previous experiments. The study highlights the potential Sc radionuclide for positronium lifetime imaging (PLI).
In vivo voxel-wise positronium lifetime imaging of thyroid cancer using clinically routine I-124 PET/CT
L. Mercolli, W.M. Steinberger, T. Lappchen, M. Amon, C. Bregenzer, M. Conti, A.R. Felgosa Cardoso, C. Mingels, P. Moskal, N. Rathod, H. Sari, E.Ł. Stępień, S. Weidner, A. Rominger, K. Shi, R. Seifert
abstract
Purpose:
Measuring the lifetime of orthopositronium (oPs) has emerged as a promising approach for assessing tumor microenvironment characteristics, leveraging the susceptibility of oPs lifetime to local molecular factors. This study investigates the feasibility of voxel-wise oPs lifetime measurements in patients with thyroid cancer using a commercial long axial field-of-view (LAFOV) PET/CT scanner.
Methods:
Three patients with thyroid cancer underwent two PET/CT scans at 2 and 26 h post-administration [124I]NaI, which included a 30 min scan in singles mode that allows to identify three-photon events. For regions with high 124I uptake, we determined the lifetime of oPs through a Bayesian fit for a voxel-based (with a voxel size of 7 × 7 × 7 mm3), lesion-based and organ-based analysis.
Results:
The oPs lifetime of the voxel with the highest count statistics and activity concentration of 108.1 kBq mL-1 is 1.77 ? 0.26 ns. The visualization of the oPs lifetimes inside a lesion was feasible, though it remains affected by statistical uncertainty. On a per-lesion basis, the lifetime could be measured (exemplary lesion:1.90 ? 0.17 ns) with mean activity concentrations ranging from 9.5 to 34.1 kBq mL-1 and volumes of 1.31 to 6.27 mL. The positronium lifetime measurement error shows a slight correlation (r=0.48 with BF10=7.88) with activity concentration of the regarded region. Besides lesions, the positronium lifetime could also be determined in several organs.
Conclusion:
This is the first report of human in-vivo measurement of oPs lifetime with [124I]NaI using a commercial LAFOV PET/CT scanner. The voxel-wise oPs lifetime imaging is feasible, though with a high statistical uncertainty. Lesion-based measurements can yield satisfactory statistical precision even for small volumes.
Studies of CPT symmetry in positronium decays with 192 plastic strip J-PET detector
N. Chug, S. D. Bass, E. Y. Beyene, C. Curceanu, E. Czerwiński, M. Das, K. V. Eliyan, M. Gorgol, J. Hajduga, S. Jalali, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, A. Kierys, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, A. Kunimmal Venadan, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, S. Niedźwiecki, P. Pandey, S. Parzych, E. Pérez del Río, A. Porcelli, B. Rachwał, M. Rädler, A. Sienkiewicz, S. Sharma, M. Skurzok, E. Ł. Stępień, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, P. Moskal
abstract
A direct test of the CPT symmetry is performed for the electromagnetic decays of ortho-positronium using the Jagiellonian positron emission tomograph (J-PET). We present the precise measurement of the CPT-sensitive angular correlation entailing the positronium spin and the momenta of its annihilation photons, surpassing previous studies utilizing the same detection system. Positrons originating from a 22Na source are emitted from the detector?s center and subsequently form positronium atoms within the spherical chamber covered with porous material. Reconstruction of annihilation locations using the 192-strip J-PET detector makes it possible to determine the positronium emission direction, which defines the quantization axis along which positronium is polarized, without the application of external magnetic fields. The measurements were performed in total for 356 days resulting in an identification of 47.8×10^6 events with ortho-positronium decays into three photons. The results are consistent with the exactness of CPT symmetry with measured asymmetry amplitude -0.00029+-0.00022 (stat.) and with statistical error four times smaller than the previous best measurement.
Nanoporosity imaging by positronium lifetime tomography
K. Dulski, E. Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, M. Gorgol, B. Jasińska, K. Kacprzak, Ł. Kapłon, G. Korcyl, T. Kozik, K. Kubat, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Niedźwiecki, P. Pandey, S. Parzych, E. Perez del Rio, M. Rädler, S. Sharma, M. Skurzok, K. Tayefi, P. Tanty, E.Ł. Stępień, P. Moskal
abstract
Positron Annihilation Lifetime Spectroscopy (PALS) is a well-established non-destructive technique used for nanostructural characterization of porous materials. It is based on the annihilation of a positron and an electron. Mean positron lifetime in the material depends on the free voids size and molecular environment, allowing the study of porosity and structural transitions in the nanometer scale. We have developed a novel method enabling spatially resolved PALS, thus providing tomography of nanostructural characterization of an extended object. Correlating space (position) and structural (lifetime) information brings new insight in materials studies, especially in the characterization of the purity and pore distribution. For the first time, a porosity image using stationary positron sources for the simultaneous measurement of the porous polymers XAD4, silica aerogel powder IC3100, and polyvinyl toluene scintillator PVT by the J-PET (Jagiellonian Positron Emission Tomography) system is demonstrated.
Hardware-agnostic framework for general-purpose data acquisition systems
G. Korcyl, M. Bakalarek, P. Moskal
abstract
Modern data acquisition systems in physics experiments of various scales rely heavily on precise time synchronization of electronic components used for digitizing analog signals generated by detectors. Scientific collaborations often develop custom, in-house solutions designed for particular use cases that form ecosystems of compatible hardware platforms, protocols, and standards.
In this work, we present and evaluate a set of gateware and software components that enable the implementation of complete data acquisition systems with synchronization, data transport, and control functionalities over multi-gigabit transceivers. The components can be organized to form a logical system structure, including the master, data concentrators, and endpoint modules, on virtually any hardware platform equipped with a Field-Programmable Gate Array with an exposed transceiver. The system allows for a rapid deployment of complete measurement systems with facilitated integration of new elements on both commercially available and custom-designed platforms.
Towards Charge Conjugation Symmetry Test in Electromagnetic Interaction Using J-PET
P. Tanty, E. Perez del Rio, P. Moskal
abstract
Charge conjugation symmetry (C-symmetry) is well-known to be maximally violated in weak interactions. However, its conservation is yet to be tested in electromagnetic and strong interactions. With the aim to test this symmetry in electromagnetic interactions, the forbidden decay channel of the triplet positronium state ? the ortho-positronium ? shall be explored. The C-symmetry forbids this state from decaying into anything other than an odd number of photons; henceforth, a search for four-photon decay extends the feasibility of testing the C-symmetry in electromagnetic interaction using the J-PET detector. Furthermore, the bosonic nature of photons hints at a distinct configuration in the event of a C-symmetry violation. Known for its outstanding timing and angular resolution, J-PET offers a viable and substantial platform to perform this symmetry test. In this article, the motivation behind the study, the theoretical assumptions, and recent advancements in testing C-symmetry using J-PET shall be discussed.
Endorsing Titanium-Scandium Radionuclide Generator for PET and Positronium Imaging
P. Moskal, A. Khreptak, J. Choiński, P. Jones, I. Kadenko, A. Majkowska-Pilip, R. Palit, A. Stolarz, R. Walczak, E. Stępień
abstract
The development of PET and positronium imaging techniques is strictly related to the availability of suitable radionuclides and robust radiochemistry platforms. Among the emerging candidates, 44Sc has attracted significant interest due to its favourable physical properties, including a half-life of 4 hours, a pure emission profile, and the additional prompt -emission that enables advanced triple-photon detection schemes. These characteristics make 44Sc particularly promising for highresolution imaging and novel quantitative methodologies. However, routine clinical and preclinical implementation requires a practical, sustainable, and cost-efficient production route. In this context, we propose a titanium-scandium radionuclide generator as an optimal solution. This study focuses on optimising the synthesis of the long-lived parent isotope, 44Ti (T1/2 = 59.1 years), from which 44Sc can be selectively eluted in a chemically pure form when needed. An analysis of various production pathways was conducted, including proton and deuteron reactions on scandium, as well as alpha-particle and lithium-induced reactions on calcium, to determine the most efficient reaction parameters, target design, and expected yield. Furthermore, we identify some existing cyclotron facilities suitable for implementing this technology. Results indicate that efficient Ti production is achievable using proton beams in the 20-30 MeV range under extended irradiation conditions. The proposed generator system would enable routine and decentralised 44Sc supply. Its integration with the novel J-PET scanner may significantly reduce diagnostic costs and improve access to advanced PET imaging in regions with limited medical imaging infrastructure.
Feasibility of H Annihilation-Vertex Reconstruction with Modular J-PET: A Simulation-Based Study
P. Pandey, S. Sharma, P. Moskal, R.C. Ferguson, R. Caravita, A. K. Venadan, G. Korcyl, K. Kacprzak
abstract
The Antihydrogen Experiment: gravity, Interferometry, Spectroscopy at CERN aims to measure the gravitational acceleration of antihydrogen (H) atoms to test the weak equivalence principle for antimatter systems. In the proposed approach, a pulsed H beam, produced via charge exchange between Rydberg positronium and antiprotons, traverses a moiré deflectometer comprising two equally spaced gratings followed by a position-sensitive detector. As the beam traverses the moiré setup, H may annihilate on the gratings or nearby structures, producing high-energy pions, or continue towards the position-sensitive detector. For a high-accuracy gravity measurement, precise knowledge of the beam profile and annihilation points is essential. We present results from a feasibility study of vertex reconstruction using modular J-PET detectors spanning the full axial length of the moiré setup. The generated pions, being minimum-ionising particles, follow straight paths. The adapted method is based on the consecutive registration of each pion, defining individual tracks in a pair of modules placed 10 cm apart. The hit positions are used to reconstruct the track direction, which is then projected back to estimate the spatial coordinates of the H annihilation vertex. For this feasibility study, we developed a customised Geant4-based simulation package and an analysis algorithm that implements a track-and-extrapolate algorithm to image the annihilation vertices.
Systematic Study of Positronium Production Medium in the J-PET Experiment for the CPT Symmetry Test
N. Chug, P. Moskal
abstract
The Jagiellonian positron emission tomograph (J-PET) is a novel technology employed to detect multiple photons from positronium annihilation. It employs plastic scintillator strips optimized for the detection of photons in the sub-MeV energy range. The experimental setup consists of a positron-emitting source surrounded by chambers coated with porous materials to facilitate positronium formation. Owing to its large geometrical acceptance and high angular resolution, J-PET enables the reconstruction of various kinematic configurations of positronium annihilations, allowing for precise measurements of angular correlations in ortho-positronium decays. The detector has already demonstrated high sensitivity in charge?parity and charge?parity?time symmetry tests based on such correlations. In the present work, we report a systematic study of the effects of non-uniformity in porous materials used for positronium production in the J-PET setup, performed in the context of a charge?parity?time symmetry test. The systematic uncertainty obtained from this study is 0.59 x 10-5, and contributes negligibly to the total uncertainty of the charge?parity?time symmetry test.
Classification of Signal Events for Entanglement Studies with J-PET Using Machine Learning Techniques
D. Kumar, S. Sharma, P. Moskal
abstract
Understanding the entangled polarization of photons produced in positron?electron annihilation remains experimentally challenging. Recently, it has been proposed to utilize this correlation in positron emission tomography imaging to suppress the random background and as a diagnostic parameter. Conventional positron emission tomographs rely on the registration of the two annihilation photons from positron annihilation. However, measuring polarization correlations requires scattering of annihilation photons in the detector volume and the registration of their corresponding scatters. Such a 4-hit event topology inherently suffers from low efficiency and high background. Therefore, translating this quantum information into medical imaging requires a method to overcome the inherent limitations of conventional geometric cuts. We present a machine learning classification framework trained on simulated detector events. This approach enables a high-purity separation of polarization-correlated signal from background and simultaneously achieves a significant improvement in computational efficiency.
Developing Analysis Criteria for Charge-Parity Symmetry Studies Using Photons From Ortho-Positronium Annihilation and Compton Scattering
K.V. Eliyan, M. Skurzok, P. Moskal
abstract
The main aim of this research is to test the charge?parity discrete symmetry in the ortho-positronium (o-Ps) atom decay using the modular Jagiellonian positron emission tomography (J-PET) detector. The J-PET is distinguished by its ability to determine the polarization plane of photons emitted during positronium annihilation. The J-PET detector can investigate discrete symmetry by examining the non-zero expectation values of the symmetry-odd operators constructed from the momentum and direction of polarization plane of gamma (?) quanta coming from o-Ps annihilation. In positronium decay, the photon?photon interactions in the final state due to vacuum polarization may mimic a charge?parity symmetry violation at the level of 10-9, according to the Standard Model prediction. Currently, with the help of the 192-strip J-PET detector, the experimental limits on charge?parity symmetry violation in o-Ps decay are set at a precision value of 0.0005 ? 0.0007. Using the modular J-PET detector, we aim to improve this value by at least an order of magnitude. This article focuses on developing analysis criteria towards improving the sensitivity level for charge?parity-discrete symmetry studies in o-Ps decay using the modular J-PET detector.
Studies of attenuation effects in two- and three-photon positronium decays in phantom models
K. Kasperska, M. Skurzok, P. Moskal
abstract
Objective: Positron Emission Tomography enables non-invasive imaging of metabolic processes. Standard PET reconstructs radiotracer distribution using two back-to-back photons from electron-positron annihilation. However, about 1% of annihilations results in creation of three photons. Three photons may be created in direct annihilation and in annihilation via formation of metastable ortho-positronium carrying additional information not used by conventional PET. The Jagiellonian-PET detector allows us to use this information by applying positronium imaging based on ortho-positronium lifetime or the 3gamma/2gamma decay ratio. Accurate tomographic images require attenuation correction. This study investigates photon absorption in phantom models to form a basis for future attenuation maps for three-gamma decays. Methods: Monte Carlo simulations in ROOT and GATE were performed for water sphere, cylinder, a simplified head model, and the mesh50_XCAT phantom. Both p-Ps and o-Ps decays were simulated as uniformly distributed sources. Absorption probabilities were calculated by checking whether any photon in a multiplet interacted within the phantom. Emission-point-specific absorption maps were generated for all models. Toy Monte Carlo and GATE simulations showed good overall agreement. Results: Photon triplets from o-Ps decays experienced higher absorption than photon pairs from p-Ps due to lower individual energies and higher attenuation. Absorption maps showed dependence of photon survival probability on the decay location. In the mesh50_XCAT phantom, 24.9% of p-Ps pairs and 10.3% of o-Ps triplets escaped without interaction. Conclusions: Gamma absorption depends strongly on positronium decay mode and location, with o-Ps events experiencing higher attenuation. The generated absorption maps provide the first step toward dedicated attenuation correction for three-gamma positronium imaging, enabling accurate reconstruction in novel 3?/2? positronium imaging technique. A Study presented indicates that the absorption of 3gamma in the head is only about 2.5 times higher than for the 2gamma, which is encouraging for further development of the 3gamma/2gamma rate ratio imaging.
The muPPET Project: Application of J-PET for Cosmic Rays Investigation
A. Porcelli
abstract
The muPPET project aims to study the cause of the observed excess of muons on the ground in extensive air showers ? the so-called muon puzzle. In particular, it tests specific hypotheses that might lead to the solution of this 15-year-long-standing puzzle. The project repurposes two J-PET scanners developed by the Jagiellonian University as a muon tracker and an air-shower detection array. To make the first measurements in summer 2026, Monte Carlo simulations were used to understand the muon calibration in the muon tracker and possible array configurations. Progress achieved on these two crucial steps is presented in this work.
Mirror Matter: Towards Precise Measurement of Ortho-Positronium Lifetime
J. Mędrala-Sowa, E. Perez del Rio, P. Moskal
abstract
Positronium (Ps), an exotic atom composed of an electron and a positron, provides a unique system for testing fundamental physics and verifying quantum electrodynamic predictions. At Jagiellonian University, the J-PET detector enables high-precision studies of positronium decays and the search for dark matter. This work focuses on mirror matter, a hypothetical dark matter candidate, by comparing measured o-Ps lifetimes with quantum electrodynamic predictions to probe potential deviations.
Feasibility Study of Using Detector-Scattered Photons for Attenuation Correction in CT-less PET Imaging
S. Tiwari, S. Sharma and P. Moskal
abstract
Objective: Quantitative PET requires accurate attenuation correction (AC), which is conventionally achieved using CT-derived maps, incurring extra dose and complexity. This study explores a CT-less AC approach for the plastic scintillator-based J-PET scanner by investigating whether detector-scattered photons (DS-LORs) can serve as an intrinsic transmission source.
Methods:
Simulation Setup: The study utilized GATE v9.1 software to simulate the modular J-PET scanner, which consists of plastic scintillator strips where 511 keV photons predominantly undergo Compton scattering. Two configurations were evaluated: a uniform water cylinder and a NEMA IQlike phantom containing a cold lung insert and six hot spheres to simulate heterogeneous activity.
Analysis & reconstruction: The study isolated triple-hit coincidences to analyze angular deviations. DS-LORs were identified using a specific scatter test metric based on interaction positions and detection times. Attenuation maps were reconstructed using Filtered Back Projection (FBP) applied to the ratio of water-to-air sinograms.
Results: Due to the properties of plastic scintillators, DS-LORs constituted approximately 50% of all detected prompts, providing a substantial dataset for analysis. In a simulated 10-minute acquisition, the noise propagation analysis yielded a Signal-to-Noise Ratio (SNR) of ? 33.9 for water. This is significantly higher than conventional crystal-based PET, which yields only ? 5% DS-LORs and a lower SNR. Reconstructions successfully resolved the NEMA phantom features, including the cold lung insert and hot spheres, particularly when phantom-scattered events were rejected.
Conclusions and future directions: This study confirms that DS-LORs retain sufficient attenuation information to estimate ?-maps, demonstrating the potential for fully CT-less PET imaging. While the current implementation faces limitations like reliance on blank scans and activity-attenuation crosstalk, the high statistics of DS-LORs are a foundation for developing joint reconstruction algorithms aiming towards clinical application.
Cryo-TEM and NTA Characterisation of Hyperglycemia-Induced Variability in Morphology and Size Distribution of EVs
M. Słotwiński, E. Stępień, A. Kyzioł, M. Rawski
abstract
Introduction: Extracellular vesicles (EVs) are membrane-bound structures that play a crucial role in intercellular communication and molecular transport. Due to their biological functions, EVs hold great potential as a novel diagnostic tool or as the targeted drug carriers in anticancer therapies. Elevated glucose concentrations affect cellular metabolism, thereby modifying the composition of the EVs and their lipid bilayer. This, in turn, can influence EVs' properties and morphology, which is important in their function.
Hypothesis: Hyperglycemic conditions, by altering the composition and metabolism of EVs, influence their size distribution and physicochemical properties.
Objective: Visualisation and size distribution comparison of EVs isolated from normoglycemic (NG) and hyperglycemic (HG) conditions.
Methods: Two complementary methods based on different physical principles were applied and compared in terms of their applicability: nanoparticle tracking analysis (NTA) and cryo- -transmission electron microscopy (Cryo-TEM). In this study, 1.1B4 cells were cultured in normo- (NG, 5 mM glucose) and hyperglycemic (HG, 25 mM glucose) conditions.
Results: The mean hydrodynamic EV size under hyperglycemic conditions (236 ? 28 nm) was slightly higher than the control (209 ? 43 nm; Paired Sample Wilcoxon Signed Test, p = 0.05). Physical EV sizes (Cryo-TEM), as well as mode hydrodynamic sizes (NTA) were consistent and not affected by glucose concentration. In contrast to NTA, Cryo-TEM is a more precise technique for real-size distribution analysis, whereas NTA provides a rapid and cost-effective assessment of hydrodynamic radii. The theoretical level of detection of NTA for EVs was close to what was observed in results.
Conclusions: Hyperglycemic conditions slightly influenced only the mean hydrodynamic radius of EVs, indicating effects on EV corona size and the biogenesis of large EVs (lEVs).
Optimising the event selection of the total-body J-PET scanner with a brain PET insert: A simulation study
M. Rädler, P. Moskal
abstract
Objective: Positron emission tomography (PET) scanners with plastic scintillators offer
more cost-effective instrumentation to image the distribution of radiopharmaceuticals.
However, inter-detector scatters among plastic scintillators can lead to more false
coincidences than in conventional PET scanners, since annihilation photons in plastic
scintillators dominantly interact via Compton scattering, which deposits only a portion
of the photon energy. A scatter test (ST), combined with a lower energy deposition
threshold of 200 keV, has been used to preselect the coincidence events.
Methods: In this work, we investigate the impact of temporal and spatial resolution
limitations as well as a variation of the energy threshold on the preselection and
different subsequent coincidence event selection policies via Monte Carlo simulations.
We simulate the total-body Jagiellonian-PET (TB-J-PET), combined with a brain PET
insert imaging a human-sized water phantom.
Results: We find that coincidence time resolution (CTR) worse than 200 ps poses
limitations on the ST for scanners close to the patient, such as the brain PET. Also,
coincidence event selection requiring energy loss higher than 200 keV performs suboptimally,
whereas a lower energy threshold (50 keV), combined with a time-based
selection policy, can capture a higher percentage of true events, even under realistic
time resolution.
Conclusions: We recommend the adaptation of a time-based event selection policy
together with a lowered energy threshold, which can also significantly increase
sensitivity, as the latter rises faster than the fraction of true and non-phantom-
-scattered events decreases. Dedicated analyses in the scatter-corrected image
domain are necessary to further investigate this potential.
First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT
L. Mercolli, W.M. Steinberger, P.V. Grundler, A. Moiseeva, S. Braccini, M. Conti, P. Moskal, N. Rathod1, A. Rominger, H. Sari, R. Schibli, R. Seifert, K. Shi, E.Ł. Stępień, N.P. van der Meulen
abstract
Purpose: The physical properties of 44Sc, combined with its imminent clinical application, position it as a prime candidate for in vivo positronium lifetime imaging. In this study, we investigate the count statistics for ortho-positronium (oPs) measurements with 44Sc on a commercial long-axial field-of-view (LAFOV) PET/CT.
Method: A NEMA image quality phantom was filled with 41.7 MBq of 44Sc dissolved in water and scanned on a LAFOV PET/CT. Three-photon events were identified using a prototype feature of the scanner and dedicated software. The lifetime of oPs was determined in the phantom spheres and in 4×4×4 mm3 voxels.
Results: All measured oPs lifetimes are compatible, within the uncertainties, with the literature values for water. The oPs lifetime is 2.65?0.50 , 1.39?0.20 and 1.76?0.18 ns in the three smallest spheres of the phantom and 1.79?0.57 ns for a single voxel in the central region of the largest sphere. The relative standard deviation in the background regions of the time difference distributions, i.e., for time differences smaller than ?2.7 ns, is above 20%?even for voxels inside the phantom spheres.
Conclusions: Despite the favorable physical properties of 44Sc, the count statistics of three-photon events remains a challenge. The high prompt-photon energy causes a significant amount of random three-photon coincidences with the given methodology and, therefore, increases the statistical uncertainties on the measured oPs lifetime.
Lipid analysis in biological structures - Is time-of-flight secondary ion mass spectrometry a valuable tool in nano-lipidomics?
M. Skalska
abstract
Introduction: Lipids are crucial biomolecules that confer structural integrity to cell membranes, facilitate signalling and regulate energy dynamics. Dysregulation of lipids is associated with various diseases, including diabetes, chronic inflammation, and neurological and cardiovascular disorders.
Objective: This review seeks to critically evaluate recent advancements in lipidomics, particularly concerning membranous nanoparticles such as extracellular vesicles (EVs), and to investigate the analytical potential of time-of-flight secondary ion mass spectrometry (ToF-SIMS) for nanoscale lipid mapping.
Methods: A comprehensive literature review was conducted, focusing on mass spectrometry (MS)-based lipidomic methodologies. Particular emphasis was placed on studies utilising ToF-SIMS to image lipid distribution and composition in cells and membrane-bound nanoparticles. While traditional MS techniques are proficient in identifying and quantifying lipids, they lack spatial resolution. ToF-SIMS addresses this limitation by enabling in situ molecular imaging at micrometre scales, revealing lipid heterogeneity within biological structures and providing unique insights into membrane architecture and lipid sorting. A comparative evaluation highlights both the strengths (e.g., spatial accuracy) and limitations (e.g., challenges in quantification) of ToF-SIMS in relation to alternative methods.
Conclusions: ToF-SIMS introduces a critical spatial dimension to lipidomics, bridging conventional bulk analysis with nano-lipidomic imaging. Its integration with complementary techniques holds promise for novel insights into lipid biology, biomarker discovery, and translational applications in diagnostics and drug delivery.
Positronium Imaging: History, Current Status, and Future Perspectives
Paweł Moskal, Aleksander Bilewicz, Manish Das, Bangyan Huang, Aleksander Khreptak, Szymon Parzych, Jinyi Qi, Axel Rominger, Robert Seifert, Sushil Sharma, Kuangyu Shi, William Steinberger, Rafał Walczak, Ewa Stępień
abstract
Positronium imaging was recently proposed to image the properties of positronium atoms in the patient body. Positronium properties depend on the size of intramolecular voids and oxygen concentration; therefore, they deliver information different and complementary to the anatomic, morphological, and metabolic images. Thus far, the mean ortho-positronium lifetime imaging has been at the center of research interest. The first ex vivo and in vivo positronium lifetime images of humans have been demonstrated with the dedicated J-PET scanner enabling simultaneous registration of annihilation photons and prompt gamma from beta+gamma emitters. Annihilation photons are used to reconstruct the annihilation place and time while prompt gamma is used to reconstruct the time of positronium formation. This review describes recent achievements in the translation of positronium imaging into clinics. The first measurements of positronium lifetime in humans with commercial PET scanners modernized to register triple coincidences are reported. The in vivo observations of differences in ortho-positronium lifetime between tumor and healthy tissues and between different oxygen concentrations are discussed. So far, the positronium lifetime measurements in humans were completed with clinically available 68Ga, 82Rb, and 124I radionuclides. Status and challenges in developing positronium imaging on a way to a clinically useful procedure are presented and discussed.
Quality control of plastic scintillators for the total-body J-PET scanner
Ł. Kapłon, E. Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, K. Eliyan, K. Kacprzak, T. Kaplanoglu, G. Korcyl, K. Kubat, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, G. Moskal, W. Mryka, S. Niedźwiecki, P. Pandey, S. Parzych, E. Pérez del Rio, S. Sharma, M. Skurzok, P. Tanty, K. Tayefi, A. Venadan, E. Stępień and P. Moskal
abstract
The construction of the total-body Jagiellonian positron emission tomography scanner requires component verification before detector assembly. The purpose of this research is to verify the quality of BC-408 plastic scintillators with dimensions 6 mm × 30 mm × 330 mm. The scintillators were inspected for optical and mechanical defects and all dimensions were measured. Scratches, mechanically damaged corners and edges, as well as encapsulated dust and fibers within the scintillators, were identified under ceiling lamp illumination. Line defects on the as-cast surfaces were easily visible in a plane polariscope setup consisting of crossed horizontal and vertical polarizer foils. The transmittance at the wavelength of maximum emission through 6 mm thick scintillator samples and the technical attenuation length along 330 mm long scintillator samples were measured on a linear CCD array spectrometer for randomly selected scintillators from each delivered batch. Selected properties of the emission spectra, such as their FWHM and the values of the emission maxima as a function of the distance between the excitation point and the spectrometer fiber, were measured. Additionally, the scintillators optical homogeneity was measured on a light transfer setup consisting of an LED and photodiode matrix. The majority of the obtained plastic scintillators meets the transparency criteria and falls within the dimensional tolerances.
Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and 124I
Lorenzo Mercolli, William M. Steinberger, Narendra Rathod, Maurizio Conti Paweł Moskal, Axel Rominger, Robert Seifert, Kuangyu Shi, Ewa Ł. Stępień, Hasan Sari
abstract
Purpose: Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner.
Methods: We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of 124I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 min scan time) and once with all samples taped together (40 min scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are 10.03 mm3, 7.13 mm3 and 4.03 mm3.
Results: Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 +- 0.03 ns, 2.37 +- 0.03 ns, 2.27 +- 0.04 ns and 1.82 +- 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.03 mm3 voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes.
Conclusions: Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using 124I.
muPPET: Investigating the Muon Puzzle with J-PET Detectors
A. Porcelli, K. Valsan Eliyan, G. Moskal, N. Nasrin Protiti, D. L. Sirghi, E. Yitayew Beyene, N. Chug, C. Curceanu, E. Czerwiński, M. Das, M. Gorgol, J. Hajduga, S. Jalali, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Kasperska, A. Khreptak, G. Korcyl, T. Kozik, D. Kumar, K. Kubat, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, W. Mryka, S. Moyo, S. Niedźwiecki, S. Parzych, P. Pandey, E. Perez del Rio, B. Rachwał, M. Rädler, S. Sharma, M. Skurzok, E. Ł. Stępień, T. Szumlak, P. Tanty, K. Tayefi Ardebili, S. Tiwari, and P. Moskal
abstract
The muPPET [muon Probe with J-PET] project aims to investigate the Muon
Puzzle seen in cosmic ray air showers. This puzzle arises from the observation of a significantly
larger number of muons on Earth's surface than that predicted by the current
theoretical models. The investigated hypothesis is based on recently observed asymmetries
in the parameters for the strong interaction cross-section and trajectory of an outgoing particle
due to projectile-target polarization. The measurements require detailed information
about muons at the ground level, including their track and charge distributions. To achieve
this, the two PET scanners developed at the Jagiellonian University in Krakow (Poland),
the J-PET detectors, will be employed, taking advantage of their well-known resolution
and convenient location for detecting muons that reach long depths in the atmosphere.
One station will be used as a muon tracker, while the second will reconstruct the core of
the air shower. In parallel, the existing hadronic interaction models will be modified and
fine-tuned based on the experimental results. In this work, we present the conceptualization
and preliminary designs of muPPET.
Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a novel plastic PET scanner
P. Moskal, D. Kumar, S. Sharma, E.Y. Beyene, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Das, K. Dulski, M. Gorgol, B. Jasinska, K. Kacprzak, T. Kaplanoglu, L. Kaplon, T. Kozik, E. Lisowski, F. Lisowski, W. Mryka, S. Niedzwiecki, S. Parzych, E.P. del Rio, M. Radler, M. Skurzok, E. L. Stepien, P. Tanty, K. Tayefi Ardebili, K. Valsan Eliyan
abstract
In the state-of-the-art Positron Emission Tomography (PET), information about the polarization of annihilation photons is not available. Current PET systems track molecules labeled with positron-emitting radioisotopes by detecting the propagation direction of two photons from positron-electron annihilation. However, annihilation photons carry more information than just the site where they originated. Here we present a novel J-PET scanner built from plastic scintillators, in which annihilation photons interact predominantly via the Compton effect, providing information about photon polarization in addition to information on photon direction of propagation. Theoretically, photons from the decay of positronium in a vacuum are maximally entangled in polarization. However, in matter, when the positron from positronium annihilates with the electron bound to the atom, the question arises whether the photons from such annihilation are maximally entangled. In this work, we determine the distribution of the relative angle between polarization orientations of two photons from positron-electron annihilation in a porous polymer. Contrary to prior results for positron annihilation in aluminum and copper, where the strength of observed correlations is as expected for maximally entangled photons, our results show a significant deviation. We demonstrate that in porous polymer, photon polarization correlation is weaker than for maximally entangled photons but stronger than for separable photons. The data indicate that more than 40% of annihilations in Amberlite resin lead to a non-maximally entangled state. Our result indicates the degree of correlation depends on the annihilation mechanism and the molecular arrangement. We anticipate that the introduced Compton interaction-based PET system opens a promising perspective for exploring polarization correlations in PET as a novel diagnostic indicator.
Realistic total-body J-PET geometry optimization: Monte Carlo study
J. Baran, W. Krzemień, L. Raczyński, M. Bała, A. Coussat, S. Parzych, N. Chug, E. Czerwiński, C. Oana Curceanu, M. Dadgar, K. Dulski, K. Eliyan, J. Gajewski, A. Gajos, B. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, G. Korcyl, T. Kozik, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Skurzok, E. Stępień, F. Tayefiardebili, K. Tayefiardebili, W. Wiślicki, P. Moskal
abstract
Total-Body PET imaging is one of the most promising newly introduced modalities in the medical diagnostics. State-of-the-art PET scanners use inorganic scintillators such as L(Y)SO or BGO, however, those technologies are very expensive, prohibitng the broad total-body PET applications. We present the comparative studies of performance characteristics of the cost-effective Total-Body PET scanners using Jagiellonian PET (J-PET) technology that is based on plastic scintillators. Here, we investigated in silico five realistic Total-Body scanner geometries, varying the number of rings, scanner radius, and distance between the neighbouring rings. Monte Carlo simulations of two NEMA phantoms (2-meter sensitivity line source and image quality) and the anthropomorphic XCAT phantom, were used to assess the performance of the tested geometries. We compared the sensitivity profiles and we performed the quantitative analysis of the reconstructed images by using the quality metrics such as contrast recovery coefficient, background variability and root mean squared error. The optimal scanner design was selected for the first Total-Body J-PET scanner configuration.
Total Body PET/CT: Clinical Value and Future Aspects of Quantification in Static and Dynamic Imaging
N. Rathod, W. Jutidamrongphan, W.A. Bosbach, Y. Chen, J. L. Penner, H. Sari, K. Zeimpekis, A. Lopez Montes, P. Moskal, E. Stepien, K. Shi, A. Rominger, and R. Seifert
abstract
Total body (TB) Positron Emission Tomography (PET) / Computed Tomography (CT) scanners have revolutionized nuclear medicine by enabling whole-body imaging in a single bed position.1 This review assesses the physical and clinical value of TB-PET/CT, with a focus on the advancements in both static and dynamic imaging, as well as the evolving quantification techniques. The significantly enhanced sensitivity of TB scanners can reduce radiation exposure and scan time, offering improved patient comfort and making it particularly useful for pediatric imaging and various other scenarios. Shorter scan times also decrease motion artifacts, leading to higher-quality images and better diagnostic accuracy. Dynamic PET imaging with TB scanners extends these advantages by capturing temporal changes in tracer uptake over time, providing real-time insights into both structural and functional assessment, and promoting the ability to monitor disease progression and treatment response. We also present CT-free attenuation correction methods that utilize the increased sensitivity of TB-PET as a potential improvement for dynamic TB-PET protocols. In static imaging, emerging quantification techniques such as dual-tracer PET using TB scanners allow imaging of two biological pathways, simultaneously, for a more comprehensive assessment of disease. In addition, positronium imaging, a novel technique utilizing positronium lifetime measurements, is introduced as a promising aspect for providing structural information alongside functional quantification. Finally, the potential of expanding clinical applications with the increased sensitivity of TB-PET/CT scanners is discussed.
Development of correction techniques for a J-PET scanner
M. Das, R. Bayerlein, S. Sharma, S. Parzych, S. Niedźwiecki, R. Badawi, E. Yitayew Beyene, N. Chug, C. Curceanu, E. Czerwiński, K. Valsan Eliyan, B. Głowa, A. Hubalewska-Dydejczyk, K. Kacprzak, T. Kaplanoglu, K. Kasperska, G. Korcyl, A. Khreptak, K. Kubat, D. Kumar, E. Lisowski, F. Lisowski, J. Mędrala-Sowa, S. Moyo, W. Mryka, M. Opalińska, P. Pandey, M. Rädler, M. Skurzok, A. Sowa-Staszczak, B. A. Spencer, P. Tanty, K. Tayefi Ardebili, A. Kunimmal Venadan, E. Stępień, P. Moskal
abstract
Objective: Positron Emission Tomography (PET) is a widely used medical imaging technique that allows for non-invasive imaging of metabolic processes. However, traditional PET scanners rely on costly inorganic scintillators, which limit their accessibility ? especially in light of emerging long axial field-of-view devices. The modular J-PET scanner, an innovative alternative, uses 50-cm long plastic scintillator strips, offering a cost-effective and modular solution. In this study, we develop and assess the PET data correction techniques required for quantitative image reconstruction. Methods: We present methods for attenuation correction, random coincidence correction using the Delayed Time Window (DTW) technique, and scatter correction based on Monte Carlo simulations. Phantom studies using the NEMA IQ phantom were performed to qualitatively evaluate these corrections. Results: The results demonstrate that our implemented corrections for attenuation, randoms, and scattered coincidences successfully improve the uniformity of tracer distribution in homogenous volumes and significantly reduce undesired activity in cold regions. Despite limitations in sensitivity and axial resolution, the applied correction techniques effectively enhance image quality, providing promising results for future applications. Conclusions: These findings highlight the potential of the modular J-PET system to offer affordable PET imaging and to pave the way towards a total-body PET scanner based on plastic scintillators. Future work will focus on quantitative validation and the implementation of these corrections for human subject imaging.
A vision to increase the availability of PET diagnostics in low- and medium-income countries by combining a low-cost modular J-PET tomograph with the 44Ti/44Sc generator
P. Moskal, E. Stępień, A. Khreptak
abstract
Objective: The paper presents the prospects for increasing the availability of PET diagnostic by combining low-cost, lightweight, and easily portable modular J-PET with the 44Ti/44Sc generator.
Methods: J-PET is constructed based on the low-cost axially arranged plastic scintillators that may enable construction of PET scanners 5 to 10 times less expensive compared to current PET systems which are based on crystal detectors. Development of the radionuclide 44Ti/44Sc generator with the 60 years half-lifetime would facilitates long-term onsite production of 44Sc labelled radiopharmaceuticals, eliminating the need for extensive and costly infrastructure typically associated with nuclear medicine. Presently applied 68Ge/68Ga generators with the 270 days half-lifetime require renewal every year. 44Ti/44Sc generator could in principle be purchased once for half a century.
Results: The lightweight and portable J-PET scanner, combined with the 44Ti/44Sc generator, can be deployed in remote and underserved regions, thus democratising access to advanced medical imaging technologies.
Conclusions: This research highlights the transformative potential of combining innovative J-PET technology with the 44Ti/44Sc generator to make advanced diagnostics more accessible and affordable worldwide, potentially benefiting millions of patients and driving further innovations in medical imaging including in low- and medium-income countries.
Advancing Cardiac Detection in Chest X-ray Images Using Machine Learning: A Practical Application of AI in Medical Imaging
N. Rathod, K. Awasthi, M. Kostkiewicz, P. Klimeczek, E. Stępień
abstract
The integration of artificial intelligence in medical imaging has revolutionised diagnostic capabilities, particularly in the field of cardiology. This study presents an innovative approach to automated cardiac region detection in chest X-ray images using advanced deep learning techniques. We developed and evaluated multiple convolutional neural network architectures, with ResNet-50 emerging as the optimal model for precise cardiac region localisation. Utilising a dataset of 496 high-resolution DICOM images (1024 × 1024), we implemented a comprehensive preprocessing pipeline including intelligent scaling, normalisation, and advanced data augmentation techniques [1, 2]. The model achieved remarkable accuracy in predicting bounding box [3?5] coordinates for cardiac region delineation, demonstrating robust performance across diverse clinical scenarios. Our findings suggest significant potential for improving diagnostic efficiency and accuracy in clinical settings, particularly in resource-constrained environments where expert radiological interpretation may be limited.
Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study
M. Durak-Kozica, E. Stępień, J. Swakoń, B. R. Jany, K. Kawoń, D. Wróbel, S. Kusyk, M. Grzesiak , K. Knapczyk-Stwora, A. Wróbel, J. Chwiej, and P. Moskal
abstract
Introduction: Melanoma, an aggressive and highly immunogenic cancer, arises from uncontrolled melanocyte growth. FLASH radiotherapy, a breakthrough technique, delivers ultra-high radiation doses, offering the potential for improved cancer treatment while minimizing harm to healthy tissue.
Material and Methods: To study the short-term response of spheroids to FLASH radiotherapy, 3D cultures of melanocytes and melanoma were used. Spheroids were irradiated using the FLASH method with the total doses of 3, 20, and 40 Gy, and conventionally with a dose of 3 Gy. After 8 days from irradiation, the measurements were taken using an imaging cytometer, FTIR and colorimetric microscopy (C-Microscopy).
Results: Studies conducted on melanocytes showed that doses of 20 and 40 Gy are toxic to them and cause cell necrosis. In contrast, for melanoma, these two doses resulted in tumor growth inhibition. IR measurements revealed spectral changes in lipids, proteins, and DNA/RNA, indicating similarities between the effects of the FLASH method and conventional radiotherapy for both spheroid models (i.e., cancerous and normal). The spheroid quantitative color analysis allowed for the differentiation between different irradiated and control groups.
Conclusion: Both colorimetric and infrared microscopy can be used to analyse the response of tumors to radiation.
Calibration of PALS System with CRM Materials for Biomedical Studies
K. Kubat, Ł. Kapłon, P. Moskal, E. Stępień
abstract
Objective and method: Positron annihilation lifetime spectroscopy (PALS) is a powerful technique in material science that allows the investigation of the properties and behavior of positrons in various materials. PALS can be used to investigate solid structures at the nanometer scale and enable the use of positronium properties as an additional diagnostic parameter. Here we present results from calibration of the PALS system with certificated reference materials (CRM).
Materials: Source of 22Na covered with layer of Kapton film, and after that parafilm from both sides was used in all experiments. Certified materials of No_5602-a (polycarbonate) and No_5601-a (fused silica) were used to ascertain if parameters were correctly identified.
Results: In an experiment three lifetime components were correctly identified. All of those components will always be present in the data in further experiments on biological samples. Lifetime components consist of: 196 ps for annihilations in AI an aluminium cover of the chamber, 386 ps for annihilations in thesource and in the Kapton foil, 463 ps for reactions with parafilm.
Conclusions: These parameters will be further used to correctly identify positron lifetimes in biological samples. Recently, a new method for imaging of positronium properties was invented and the first in-vivo images of positronium lifetime in humans were demonstrated with the multi-photon J-PET scanner. In order to correlate the positronium properties in tissue with the medically useful parameters, and to translate positronium imaging to clinics, comprehensive research of positronium properties in biological samples is needed.
Calculational Cross-Sections of (p, x) Reactions on the 12C, 14N and 16O for 10,11C Production
N. Sakhno, W. Mryka, O. Gorbachenko, I. Kadenko, E. Stępień, P. Moskal
abstract
For in vivo dose delivery monitoring in proton therapy the positron emission tomography can be applied because the positron emitters are being produced by the nuclear reactions of protons with atomic nuclei in a human body. The estimation of cross-sections of proton-induced nuclear reactions in the body is, therefore, one of the important steps on the way to develop proton beam range monitoring with positron emission tomography. Here, we calculate cross-sections for all open nuclear reaction channels initiated by 150 MeV protons and featured with 10C and 11C formation in the output channels. Taking into account the composition of elements in the human body and the data from the literature, we estimated 10C and 11C cumulative production cross-sections for proton-induced reactions in the human body.
Assessing the Spatial Resolution of the Modular J-PET Scanner using the Maximum-Likelihood Expectation-Maximization (MLEM) algorithm
F. Tayefi Ardebili, P. Moskal
abstract
The presented study evaluates the spatial resolution of the Modular J-PET scanner using the National Electrical Manufacturers Association (NEMA) NU2-2018 standard. The Modular J-PET, constructed with BC-404 plastic scintillators in an axial arrangement and coupled with analogue Silicon Photomultipliers (SiPMs) at both ends, offers a 50 cm axial field of view and a bore diameter of 73.9 cm. The study compares results from GATE simulations with experimental data.
Positron Emission Tomography Could Be Aided by Entanglement
P. Moskal
abstract
The quantum entanglement of photons used in positron emission tomography (PET) scans has been shown to be surprisingly robust, opening prospects for developing quantum-enhanced PET schemes.
Positronium image of the human brain in vivo
P. Moskal, J. Baran, S. Bass, J. Choiński, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, M. Das, K. Dulski, K.V. Eliyan, K. Fronczewska, A. Gajos, K. Kacprzak, M. Kajetanowicz, T. Kaplanoglu, Ł. Kapłon, K. Klimaszewski, M. Kobylecka, G. Korcyl, T. Kozik, W. Krzemień, K. Kubat, D. Kumar, J. Kunikowska, J. Mączewska, W. Migdał, G. Moskal, W. Mryka, S. Niedźwiecki, S. Parzych, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, F. Tayefi, K. Tayefi, P. Tanty, W. Wiślicki, L. Królicki, E. Ł. Stępień
abstract
Positronium is abundantly produced within the molecular voids of a patient?s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner
W. M. Steinberger, L. Mercolli, J. Breuer, H. Sari, S. Parzych, S. Niedzwiecki, G. Lapkiewicz, P. Moskal, E. Stepien, A. Rominger, K. Shi, M. Conti
abstract
Background: Positron emission tomography (PET) traditionally uses coincident
annihilation photons emitted from a positron interacting with an electron to localize
cancer within the body. The formation of positronium (Ps), a bonded electron-positron
pair, has not been utilized in clinical applications of PET due to the need to detect
either the emission of a prompt gamma ray or the decay of higher-order coincident
events. Assessment of the lifetime of the formed Ps, however, can potentially yield
additional diagnostic information of the surrounding tissue because Ps properties vary
due to void size and molecular composition. To assess the feasibility of measuring Ps
lifetimes with a PET scanner, experiments were performed in a Biograph Vision Quadra
(Siemens Healthineers). Quadra is a long-axial field-of-view (LA-FOV) PET scanner capable
of producing list-mode data from single interaction events.
Results: Ortho-Ps (o-Ps) lifetimes were measured for quartz-glass and polycarbonate
samples using a 22Na positron source. Results produced o-Ps lifetimes of 1.538 ? 0.036
ns for the quartz glass and 1.927 ? 0.042 ns for the polycarbonate. Both o-Ps lifetimes
were determined using a double-exponential fit to the time-difference distribution
between the emission of a prompt gamma ray and the annihilation of the correlated
positron. The measured values match within a single standard deviation of previously
published results. The quartz-glass samples were additional measured with 82Rb , 68 Ga
and 124I to validate the lifetime using clinically available sources. A double-exponential
fit was initially chosen as a similar methodology to previously published works, however,
an exponentially-modified Gaussian distribution fit to each lifetime more-accurately
models the data. A Bayesian method was used to estimate the variables of the fit
and o-Ps lifetime results are reported using this methodology for the three clinical
isotopes: 1.59 ? 0.03 ns for 82Rb , 1.58 ? 0.07 ns for 68Ga and 1.62 ? 0.01 ns for 124I . The
impact of scatter and attenuation on the o-Ps lifetime was also assessed by analyzing
a water-filled uniform cylinder (20 × 30 cm3 ) with an added 82Rb solution. Lifetimes
were extracted for various regions of the cylinder and while there is a shape difference
in the lifetime due to scatter, the extracted o-Ps lifetime of the water, 1.815 ? 0.013 ns,
agrees with previously published results.
Conclusion: Overall, the methodology presented in this manuscript demonstrates
the repeatability of Ps lifetime measurements with clinically available isotopes
in a commercially-available LA-FOV PET scanner. This validation work lays the foundation
for future in-vivo patient scans with Quadra.
Feasibility of the J-PET to monitor range oftherapeutic proton beams
J. Baran, D. Borys, K. Brzeziński, J. Gajewski, M. Silarski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K.V. Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopeć, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A.J. Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, M. Simbarashe, S. Sharma, Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E.Ł. Stępień, K. Tayefi, F. Tayefi, D.C. Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Ruciński
abstract
Objective: The aim of this work is to investigate the feasibility of the JagiellonianPositron Emission Tomography (J-PET) scanner for intra-treatment proton beamrange monitoring. Approach: The Monte Carlo simulation studies with GATE and PET imagereconstruction with CASToR were performed in order to compare six J-PET scannergeometries (three dual-heads and three cylindrical). We simulated proton irradiationof a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out BraggPeak (SOBP) of various ranges. The sensitivity and precision of each scanner werecalculated, and considering the setup?s cost-effectiveness, we indicated potentiallyoptimal geometries for the J-PET scanner prototype dedicated to the proton beamrange assessment. Main results: The investigations indicate that the double-layer cylindrical andtriple-layer double-head configurations are the most promising for clinical application.We found that the scanner sensitivity is of the order of 10?5coincidences per primaryproton, while the precision of the range assessment for both SPB and SOBP irradiationplans was found below 1 mm. Among the scanners with the same number of detectormodules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibilityof the J-PET detector for PET-based proton beam therapy range monitoring ispossible with reasonable sensitivity and precision enabling its pre-clinical tests in theclinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometryconfigurations seem promising for the future clinical application. Experimental testsare needed to confirm these findings.
Feasibility studies for imaging e+e- annihilation with modular multi-strip detectors
S. Sharma, L. Povolo, S. Mariazzi, G. Korcyl, K. Kacprzak, D. Kumar, S. Niedzwiecki, J. Baran, E. Beyene, R. S. Brusa, R. Caravita, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Dadgar, M. Das, K. Dulski, K. Eliyan, A. Gajos, N. Gupta, B. C. Hiesmayr, L. Kaplon, T. Kaplanoglu, K. Klimaszewski, P. Konieczka, T. Kozik, M. K. Kozani, W. Krzemien, S. Moyo, W. Mryka, L. Penasa, S. Parzych, E. Perez Del Rio, L. Raczynski, R. Y. Shopa, M. Skurzok, E. L. Stepien, P. Tanty, F. Tayefi, K. Tayefi, W. Wislicki, P. Moskal
abstract
Studies based on imaging the annihilation of the electron (e-) and its antiparticle positron (e+) open up several interesting applications in nuclear medicine and fundamental research. The annihilation process involves both the direct conversion of ee into photons and the formation of their atomically bound state, the positronium atom (Ps), which can be used as a probe for fundamental studies. With the ability to produce large quantities of Ps, manipulate them in long-lived Ps states, and image their annihilations after a free fall or after passing through atomic interferometers, this purely leptonic antimatter system can be used to perform inertial sensing studies in view of a direct test of Einstein equivalence principle. It is envisioned that modular multistrip detectors can be exploited as potential detection units for this kind of studies. In this work, we report the results of the first feasibility study performed on a e beamline using two detection modules to evaluate their reconstruction performance and spatial resolution for imaging ee annihilations and thus their applicability for gravitational studies of Ps.
SPLIT: Statistical Positronium Lifetime Image reconstruction via time-Thresholding
B. Huang, T. Li, G, Arino-Estrada, K. Dulski, R.Y. Shopa, P. Moskal, E. Stępień, J. Qi
abstract
Positron emission tomography (PET) is a widely utilized medical imaging modality that uses positron-emitting radiotracers to visualize biochemical processes in a living body. The spatiotemporal distribution of a radiotracer is estimated by detecting the coincidence photon pairs generated through positron annihilations. In human tissue, about 40% of the positrons form positroniums prior to the annihilation. The lifetime of these positroniums is influenced by the microenvironment in the tissue and could provide valuable information for better understanding of disease progression and treatment response. Currently, there are few methods available for reconstructing high-resolution lifetime images in practical applications. This paper presents an efficient statistical image reconstruction method for positronium lifetime imaging (PLI). We also analyze the random triple-coincidence events in PLI and propose a correction methodfor random events, which is essential for real applications. Both simulation andexperimental studies demonstrate that the proposed method can produce lifetime images with high numerical accuracy, low variance, and resolution comparable to that of the activity images generated by a PET scanner with currently available time-of-flight resolution.
Discrete symmetries tested at 10^-4 precision using linear polarization of photons from positronium annihilations
P. Moskal, E. Czerwiński, J. Raj, S. D. Bass, E. Beyene, N. Chug, A. Coussat, C. Curceanu, M. Dadgar, M. Das, K. Dulski, A. Gajos, M. Gorgol, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, T. Kaplanoglu, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, S. Moyo, W. Mryka, S. Niedźwiecki, S. Parzych, E. Pérez del Río, L. Raczyński, S. Sharma, S. Choudhary, R. Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, P. Tanty, F. T. Ardebili, K. T. Ardebili, K. V. Eliyan, W. Wiślicki
abstract
Discrete symmetries play an important role in particle physics with violation of CP connected to the matter-antimatter imbalance in the Universe. We report the most precise test of P, T and CP invariance in decays of ortho-positronium, performed with methodology involving polarization of photons from these decays. Positronium, the simplest bound state of an electron and positron, is of recent interest with discrepancies reported between measured hyperfine energy structure and theory at the level of 10^-4 signaling a need for better understanding of the positronium system at this level. We test discrete symmetries using photon polarizations determined via Compton scattering in the dedicated J-PET tomograph on an event-by-event basis and without the need to control the spin of the positronium with an external magnetic field, in contrast to previous experiments. Our result is consistent with QED expectations at the level of 0.0007 and one standard deviation.
Estimating influence of positron range in proton-therapy-beam monitoring with PET
W. Mryka, M. Das, E.Y. Beyene, P. Moskal, E. Stępień
abstract
The application of PET scanners to proton-beam-therapy monitoring is a promising solution to obtain the range of the beam and hence the positions of a Bragg peak - maximum dose deposition point. A proton beam induces nuclear reactions in the tissue, leading to the production of isotopes that emit beta+ radiation. This enables the imaging of the density distribution of beta+ isotopes produced in the body, allowing the reconstruction of the proton beam range. Moreover, PET detectors may open the possibility for in-beam monitoring, which would offer an opportunity to verify the range during irradiation. PET detectors may also allow positronium imaging, which would be the indicator of the tissue conditions. However, the image of annihilation points does not represent the range of the proton beam. There are several factors influencing the translation from annihilation points to obtain the Bragg peak position. One of them is the kinetic energy of the positron. This energy corresponds to some range of the positron within the tissue. In this manuscript we estimate positron energy and its range and discuss its influence on proton therapy monitoring.
Exploration of simultaneous dual-isotope imaging with multi-photon modular J-PET scanner
Ermias Yitayew Beyene, Manish Das, Martyna Durak-Kozica, Grzegorz Korcyl, Wiktor Mryka, Szymon Niedźwiecki, Szymon Parzych, Keyvan Tayefi Ardebili, Rafał Walczak, Kamil Wawrowicz, Ewa Stępień, Paweł Moskal
abstract
The modular J-PET scanner, comprising 24 compact and versatile modules, each consisting of 13 plastic strips with four SiPM detectors at the ends, represents a powerful tool for clinical applications in nuclear medical imaging. This study presents preliminary results from the exploration of simultaneous dual-isotope imaging using the modular J-PET system. Our approach involved two isotopes: 68Ge, characterized by a ringlike shape, and 22Na, exhibiting a point-like shape. The imaging was based on double-coincidence and triple-coincidence events. In the double coincidence case, both isotopes contributed comparably, whereas in the triple coincidence case 22Na dominated due to the prompt gamma being emitted with 100% of positron emissions, unlike 68Ga, where the prompt gamma was emitted in only 1.3% of cases after positron emission. In this work we present direct 2? images determined for two-signal events and images for three-signal events, with two signals from annihilation photons and one from a prompt gamma. These results showcase the preliminary findings from simultaneous dual-isotope imaging of 68Ga and 22Na isotopes using the modular J-PET scanner, which will be presented and discussed.
Estimating the efficiency and purity for detecting annihilation and prompt photons for positronium imaging with J-PET using toy Monte Carlo simulation
M. Das, W. Mryka, E.Y. Beyene, S. Parzych, S. Sharma, E. Stępień, P. Moskal
abstract
The positronium imaging technique represents a potential enhancement of the PET imaging method. Its core principle involves employing a beta+ radiation source that emits additional gamma quanta referred to as prompt gamma. Our aim is to evaluate the capability to differentiate between annihilation and prompt gamma emissions, a vital aspect of positronium imaging. For this purpose, the selected isotopes should enable high efficiency and purity in detecting both prompt gamma and annihilation gamma. The assessment of the efficiency in identifying prompt and annihilation photons for various isotopes, which are potentially superior candidates for beta++ gamma emitters, is conducted through toy Monte-Carlo simulation utilizing the cross-section formula for photon-electron scattering. In this article, we have performed calculations for efficiency and purity values across different isotopes under ideal conditions and examined how these values evolve as we incorporate the fractional energy resolution into the analysis. Ultimately, the primary goal is to determine the energy threshold that optimizes both efficiency and purity, striking a balance between accurately identifying and recording events of interest while minimizing contamination from undesired events.
A cross-staged gantry for total-body PET and CT imaging
M. Tevfik Kaplanoglu, P. Moskal
abstract
Total-body Positron Emission Tomography (PET) scanning is a promising new method for rapidly acquiring comprehensive wide-volume metabolic data with a lower radiation dosage compared to discrete whole-body PET imaging. PET scanners are generally used with Computed Tomography (CT) scanners to precisely understand tumor location and composition with the help of anatomical images. However, PET/CT sequential imaging methods for simultaneous total-body imaging are impractical for claustrophobic patients due to the enclosed gantry design and require large examination rooms because of the need for an exceptionally long patient table. To address this challenge, the Jagiellonian--PET Tomography (J-PET) Total-body scanner employs an innovative approach: utilizing both PET and CT devices on the same patient table but from different axes. The motion system of the J-PET Total Body scanner requires custom linear stages to move both PET and CT gantries. In this study, a novel cross-staged linear guiding solution is proposed by combining scanners on intersecting separable stages. The proposed sliding system is a combination of different machine elements and will be produced for the J-PET Total-body PET/CT Scanner. Concept designs are shown, and the proposed system is described. The application of the system for the J-PET total-body PET/CT scanner is discussed. The proposed solution is still in the development phase. The system holds the potential to achieve combining CT and PET scanners from different axes and enables motion artifact-free imaging for total-body imaging.
Evaluation of Modular J-PET sensitivity
F. Tayefi Ardebili, S. Niedźwiecki, P. Moskal
abstract
The Modular J-PET represents the latest advancement in the Jagiellonian-PET series, utilizing extended plastic scintillator strips. This prototype's modular design enables cost-effective imaging of multi-photon annihilation and positronium, allowing for easy assembly, portability, and versatility. Additionally, its lightweight construction facilitates static bed examinations with a mobile detection system that can be positioned conveniently alongside the patient, negating the requirement for spacious clinical settings. Comprising 24 modules arranged in regular 24- sided polygons circumscribing a 73.9 cm diameter circle, each module integrates 13 scintillator strips, measuring 50 cm in length and 6mm×24mm in cross-section. Scintillation light is captured at both ends through analog Silicon Photomultipliers (SiPMs). This research presents Sensitivity of the Modular J-PET tomograph, adhering to the NEMA_NU 2-2018 standards. Sensitivity measurement was performed with Ge line source inside the 5 sleeves aluminium phantom placed at center of the detector`s FOV and 10 cm offset from the center of detector. Analyzing the gathered data involved employing the specialized J-PET Framework software, developed within the C++ architecture. To validate the experimental findings, comparisons were made with GATE simulations, wherein the source and phantom were emulated in the same configuration as employed in the actual experiment. The system sensitivity of the Modular J-PET was assessed to be 1.03 ? 0.02 cps/kBq in the center of the detector`s FOV with the peak sensitivity of 2.1 cps/kBq. However, the simulations indicate that at the center of the detector's FOV, the Modular J-PET achieves a system sensitivity of 1.32 ? 0.03 cps/kBq, with a peak sensitivity of 2.9 cps/kBq.
Optimization of the WLS design for positron emission mammography and Total-Body J-PET systems
A. Georgadze, S. Shivani, K. Tayefi Ardebili, P. Moskal
abstract
Total body positron emission tomography (PET) instruments are medical imaging devices that detect and visualize metabolic activity in the entire body. The PET scanner has a ring-shaped detector that surrounds the patient, which detects the gamma rays emitted by the tracer as it decays. Usually, these detectors are made up of scintillation crystals coupled to photodetectors that convert the light produced by the scintillation crystal into electrical signals. The Jagiellonian Positron Emission Mammograph (J-PEM) is the first J-PET prototype module based on a novel idea with a plastic scintillator and wavelength shifter (WLS). At the same time, it is a prototype module for the total-body J-PET system. J-PEM can be an effective system for the detection and diagnosis of breast cancer in its early stage by improving sensitivity. This can be achieved using superior timing properties of plastic scintillators and combined with the WLS sheets readout. In this paper, we present an application of the Geant4 program for simulating optical photon transport in the J-PEM module. We aim to study the light transport within scintillator bars and WLS sheets to optimize gamma-ray hit position resolution. We simulated a pencil beam of 511 keV photons impinging the scintillator bar at different locations. For each condition, we calculated the value of the pulse height centroid and the spread of the photon distribution. Some free parameters of the simulation, like the reflectivity and the effective attenuation length in the sheet, were determined from a comparison to experimental data. Finally, we estimate the influence of the application of WLS layer in the total-body J-PET on the scatter fraction. To optimize the performance of the J-PEM module, we compared geometry with the number of WLS strips 50 and 83. It was found, that spatial resolution was 2.7 mm and 3.5 mm FWHM for 50 and 83 WLS strips respectively. Despite the better granularity, the 83-strip WLS geometry exhibits poorer resolution due to fewer photons being transmitted to the strip, resulting in large fluctuations of signal.
Optimization of positronium imaging performance of a simulated modular J-PET scanner using GATE software
S. Parzych
abstract
J-PET application as a Compton camera for proton beam range verification: A preliminary study
M. K. Kozani, A. Rucinski, P. Moskal
abstract
Hybrid in-beam PET/Compton camera imaging currently shows a promising approach to use of the quasi-real-time range verification technique in proton therapy. This work aims to assess the capability of utilizing a configuration of the Jagiellonian-positron emission tomography (J-PET) scanner made of plastic scintillator strips, so as to serve as a Compton camera for proton beam range verification. This work reports the production yield results obtained from the GATE/Geant4 simulations, focusing on an energy spectrum (4.2?4.6) MeV of prompt gamma (PG) produced from a clinical proton beam impinging on a water phantom. To investigate the feasibility of J-PET as a Compton camera, a geometrical optimisation was performed. This optimisation was conducted by a point spread function (PSF) study of an isotropic 4.44 MeV gamma source. Realistic statistics of 4.44 MeV PGs obtained from the prior step were employed, simulating interactions with the detector. A sufficient number of detected photons was obtained for the source position reconstruction after performing a geometry optimisation for the proposed J-PET detector. Furthermore, it was demonstrated that more precise calculation of the total deposited energy of coincident events plays a key role in improving the image quality of source distribution determination. A reasonable spatial resolution of 6.5 mm FWHM along the actual proton beam direction was achieved for the first imaging tests. This preliminary study has shown notable potential in using the J-PET application for in-beam PET/Compton camera imaging at quasi-real-time proton range monitoring in future clinical use.
Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model - a proof of concept
M. Durak-Kozica, E. Stępień, J. Swakoń, P. Moskal
abstract
Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model ? spheroids) and the secretion of extracellular vesicles (EVs) and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are better able to mimic the tumour microenvironment.
Experimental and analytical procedures for the ToF-SIMS measurement data of membranous structures
M. Skalska, M. Durak-Kozica
abstract
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful analytical technique with great application potential in biomolecular matter research. SIMS measurements performed on biological samples, due to their complex structure and the content of many small and large atomic molecular compounds, suffer very rich and complex mass spectra of particles, which characterise the content and physio-chemical properties of examined samples. The proper description and understanding of features appearing in the spectra and, consequently, the final data confirming or rejecting the hypothesis put forward in the experiment, largely depend on the experimenter?s correct understanding of the technique itself and its limitations, knowledge of the tested material and its appropriate preparation. These issues mean that obtaining the right answer to the questions posed in the research hypothesis requires not only the correct conduct of experiments but also the appropriate processing of post-experimental data. This study aims to demonstrate the impact of various analytical and experimental procedures applied to reach proper conclusions from TOF-SIM measurements. These are different types of data normalization, the selection of a so-called region of interest (ROI), the selection of representative secondary ions and specific quantification methods, including a combination of experimental parameters. All these aspects were checked and discussed based on the results of the analysis of pancreatic ? cells placed in a PBS solution on silicon wafers.
Comparison of cell casted and 3D-printed plastic scintillators for dosimetry applications
D. Kulig, Ł. Kapłon, G. Moskal, S. Beddar, T. Fiutowski, W. Górska, J. Hajduga, P. Jurgielewicz, D. Kabat, K. Kalecińska, M. Kopeć, S. Koperny, B. Mindur, J. Moroń, S. Niedźwiecki, M. Silarski, F. Sobczuk, T. Szumlak, A. Ruciński
abstract
Currently, the most used methods of plastic scintillator (PS) manufacturing are cell casting and bulk polymerisation, extrusion, injection molding, whereas digital light processing (DLP) 3D printing technique has been recently introduced. For our research, we measured blue-emitting EJ-200, EJ-208, green-emitting EJ-260, EJ-262 cell cast and two types of blue-emitting DLP-printed PSs. The light output of the samples, with the same dimension of 10 mm × 10 mm × 10 mm, was compared. The light output of the samples, relative to the reference EJ-200 cell-cast scintillator, equals about 40?49 and 70?73% for two types of 3D-printed, and two green-emitting cell-casted PSs, respectively. Performance of the investigated scintillators is sufficient to use them in a plastic scintillation dosemeter operating in high fluence gamma radiation fields.
Comparative studies of the sensitivities of sparse and full geometries of Total-Body PET scanners built from crystals and plastic scintillators
M. Dadgar, S. Parzych, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, K. Dulski, K. Elyan, A. Gajos, B.C. Hiesmayr, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, M. Skurzok, E. L. Stępień, F. Tayefi Ardebili, K. Tayefi Ardebili, S. Vandenberghe, W. Wiślicki and P. Moskal
abstract
Background: Alongside the benefits of Total-Body imaging modalities, such as higher sensitivity, single-bed position, low dose imaging, etc., their final construction cost prevents worldwide utilization. The main aim of this study is to present a simulation-based comparison of the sensitivities of existing and currently developed tomographs to introduce a cost-efficient solution for
constructing a Total-Body PET scanner based on plastic scintillators.
Methods: For the case of this study, eight tomographs based on the uEXPLORER configuration with different scintillator materials (BGO, LYSO), axial field-of-view (97.4 cm and 194.8 cm), and detector configuration (full and sparse) were simulated. In addition, 8 J-PET scanners with different configurations, such as various axial field-of-view (200 cm and 250 cm), the different cross-sections of plastic scintillator, and the multiple numbers of the
plastic scintillator layers (2, 3, and 4), based on J-PET technology have been simulated by GATE software. Furthermore, Biograph Vision has been simulated to compare the results with standard PET scans. Two types of simulations have been performed. The first one with a centrally located source with a diameter of 1mm and a length of 250 cm, and the second one with the same source inside a water-filled cylindrical phantom with a diameter of 20 cm and a length of 183 cm.
Results: With regards to sensitivity, among all the proposed scanners, the ones constructed with BGO crystals give the best performance (? 350 cps/kBq at the center). The utilization of sparse geometry or LYSO crystals significantly lowers the achievable sensitivity of such systems. The J-PET design gives a similar sensitivity to the sparse LYSO crystal-based detectors while having full detector coverage over the body. Moreover, it provides uniform sensitivity over the body
with additional gain on its sides and provides the possibility for high-quality brain
imaging.
Conclusion: Taking into account not only the sensitivity but also the price of the Total-Body PET tomographs, which till now was one of the main obstacles in their widespread clinical availability, the J-PET tomography system based on plastic scintillators could be a cost-efficient alternative for Total-Body PET scanners.
Transformation of PET raw data into images for event classification using convolutional neural networks
P. Konieczka, L. Raczyński, W. Wiślicki, O. Fedoruk, K. Klimaszewski, P. Kopka, W. Krzemień, R.Y. Shopa, J. Baran, A. Coussat, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, G. Korcyl, T. Kozik, D. Kumar, S. Niedźwiecki, S. Parzych, E. Pérez del Río, S. Sharma, S. Shivani, M. Skurzok, E.Ł. Stępień, F. Tayefi, P. Moskal
abstract
In positron emission tomography (PET) studies, convolutional neural networks (CNNs) may be applied directly to the reconstructed distribution of radioactive tracers injected into the patient's body, as a pattern recognition tool. Nonetheless, unprocessed PET coincidence data exist in tabular format. This paper develops the transformation of tabular data into -dimensional matrices, as a preparation stage for classification based on CNNs. This method explicitly introduces a nonlinear transformation at the feature engineering stage and then uses principal component analysis to create the images. We apply the proposed methodology to the classification of simulated PET coincidence events originating from NEMA IEC and anthropomorphic XCAT phantom. Comparative studies of neural network architectures, including multilayer perceptron and convolutional networks, were conducted. The developed method increased the initial number of features from 6 to 209 and gave the best precision results (79.8) for all tested neural network architectures; it also showed the smallest decrease when changing the test data to another phantom.
Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study
K. Brzeziński, J. Baran, D. Borys, J. Gajewski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K.V. Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopeć, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A.J. Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, S. Sharma, Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E.Ł. Stępień, K. Tayefi, F. Tayefi, D.C. Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Ruciński
abstract
Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r2 = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.
Comparative studies of plastic scintillator strips with high technical attenuation length for the total-body J-PET scanner
Ł. Kapłon, J. Baran, N. Chug, A. Coussat, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, B. Hiesmayr, E. Kavya Valsan, K. Klimaszewski, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, G. Moskal, S. Niedźwiecki, D. Panek, S. Parzych, E. Pérez del Rio, L. Raczyński, A. Ruciński, S. Sharma, S. Shivani, R. Shopa, M. Silarski, M. Skurzok, E. Stępień, F. Tayefi Ardebili, K. Tayefi Ardebili, W. Wiślicki, P. Moskal
abstract
Plastic scintillator strips are considered as one of the promising solutions for the cost-effective construction of total-body positron emission tomography, (PET) system. The purpose of the performed measurements is to compare the transparency of long plastic scintillators with dimensions 6 mm x 24 mm x 1000 mm and with all surfaces polished. Six different types of commercial, general purpose, blue-emitting plastic scintillators with low attenuation of visible light were tested, namely: polyvinyl toluene-based BC-408, EJ-200, RP-408, and polystyrene-based Epic, SP32 and UPS-923A. For determination of the best type of plastic scintillator for total-body Jagiellonian positron emission tomograph (TB-J-PET) construction, emission and transmission spectra, and technical attenuation length (TAL) of blue light-emitting by the scintillators were measured and compared. The TAL values were determined with the use of UV lamp as excitation source, and photodiode as light detector. Emission spectra of investigated scintillators have maxima in the range from 420 nm to 429 nm. The BC-408 and EJ-200 have the highest transmittance values of about 90% at the maximum emission wavelength measured through a 6 mm thick scintillator strip and the highest technical attenuation length reaching about 2000 mm, allowing assembly of long detection modules for time-of-flight (TOF) J-PET scanners. Influence of the 6 mm × 6 mm, 12 mm × 6 mm, 24 mm × 6 mm cross-sections of the 1000 mm long EJ-200 plastic scintillator on the TAL and signal intensity was measured. The highest TAL value was determined for samples with 24 mm × 6 mm cross-section.
3D melanoma spheroid model for the development of positronium biomarker
H. Karimi, P. Moskal, E.Ł. Stępień
abstract
It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron emission tomography (PET). Positronium imaging utilizes properties of a positronium atoms, which are built from the electron and positron produced in the body during PET examinations.
We hypothesized whether positronium imaging would be sensitive to in vitro discrimination of tumour-like three-dimensional structures (spheroids) build of melanoma cell lines with different cancer activity and biological properties.
The lifetime of ortho-Positronium (o-Ps) was evaluated in melanoma spheroids from two cell lines (WM266-4 and WM115) differing in the stage of malignancy. Additionally, we considered such parameters: as cell size, proliferation rate and malignancy to evaluate their relationship with o-Ps lifetime. We demonstrate the pilot results for the o-Ps lifetime measurement in extracellular matrix free spheroids. With the statistical significance of two standard deviations, we demonstrated that the higher the degree of malignancy and the rate of proliferation of neoplastic cells the shorter the lifetime of ortho-positronium. In particular we observed following indications encouraging further research: (i) WM266-4 spheroids characterized with higher proliferation rate and malignancy showed shorter o-Ps lifetime compared to WM115 spheroids characterized by lower growth rate, (ii) Both cell lines showed a decrease in the lifetime of o-Ps after spheroid generation in 8th day comparing to 4th day in culture and the mean o-Ps lifetime is longer for spheroids formed from WM115 cells than these from WM266-4 cells, regardless spheroid age. The results of these study revealed that positronium is a promising biomarker that may be applied in PET diagnostics for the assessment of the degree of cancer malignancy.
Colloquium: Positronium physics and biomedical applications
S.D. Bass, S. Mariazzi, P. Moskal, E. Stępień
abstract
Positronium is the simplest bound state, built of an electron and a positron. Studies of positronium in vacuum and its decays in medium tell us about quantum electrodynamics (QED) and about the structure of matter and biological processes of living organisms at the nanoscale, respectively. Spectroscopic measurements constrain our understanding of QED bound state theory. Searches for rare decays and measurements of the effect of gravitation on positronium are used to look for new physics phenomena. In biological materials positronium decays are sensitive to the intermolecular and intramolecular structure and to the metabolism of living organisms ranging from single cells to human beings. This leads to new ideas of positronium imaging in medicine using the fact that during positron emission tomography (PET) as much as 40% of positron annihilation occurs through the production of positronium atoms inside the patient?s body. A new generation of the high sensitivity and multiphoton total-body PET systems opens perspectives for clinical applications of positronium as a biomarker of tissue pathology and the degree of tissue oxidation.
Extracellular vesicles in vascular pathophysiology: beyond their molecular content
E.Ł. Stępień, M. Durak-Kozica, P. Moskal
abstract
Extracellular vesicles (EVs) are released by all cells, both in physiological and pathological conditions. Their molecular charge and composition emerge as possible biomarkers, but EVs may also be considered for other clinical applications. This review discusses the role of other features of EVs, such as their lipid components or composition of glycans that form the EV corona and regulate EV biodistribution and uptake by target cells. The importance of EV electric charge has been discussed as a new insight into EV fate and destination.
Efficiency determination of J-PET: first plastic scintillators-based PET scanner
S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, Sz. Niedźwiecki, D. Panek, S. Parzych, E. Perez del Rio, L. Raczyński, Shivani, R. Y. Shopa, M. Skurzok, E. Ł. Stępień, F. Tayefi, K. Tayefi , W. Wiślicki and P. Moskal
abstract
Background:
The Jagiellonian Positron Emission Tomograph is the 3-layer prototype
of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators
are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV
photons emitted in e+e- annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures
the precise labeling of the 511 keV photons.
Results:
By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70-270 keV, where it varies between 20 and 100%. In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons.
Conclusion:
A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion-beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.
Developing a Novel Positronium Biomarker for Cardiac Myxoma Imaging
P. Moskal, E. Kubicz, G. Grudzień, E. Czerwiński, K. Dulski, B. Leszczyński, S. Niedźwiecki, E.Ł. Stępień
abstract
Purpose: Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50?75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocardiography (TTE) is the initial technique for the differential diagnostics of CM. Less invasive cardiac computed tomography (CT) and magnetic resonance imaging (MRI) are not available for the majority of cardiac patients. Here, a robust imaging approach, ortho-Positronium (o-Ps) imaging, is presented to determine cardiac myxoma extracted from patients undergoing urgent cardiac surgery due to unexpected atrial masses. We aimed to assess if the o-Ps atom, produced copiously in intramolecular voids during the PET imaging, serves as a biomarker for CM diagnosing.
Methods: Six perioperative CM and normal (adipose) tissue samples from patients, with primary diagnosis confirmed by the histopathology examination, were examined using positron annihilation lifetime spectroscopy (PALS) and micro-CT. Additionally, cell cultures and confocal microscopy techniques were used to picture cell morphology and origin.
Results: We observed significant shortening in the mean o-Ps lifetime in tumor with compare to normal tissues: an average value of 1.92(02) ns and 2.72(05) ns for CM and the adipose tissue, respectively. Microscopic differences between tumor samples, confirmed in histopathology examination and micro-CT, did not influenced the major positronium imaging results.
Conclusions: Our findings, combined with o-Ps lifetime analysis, revealed the novel emerging positronium imaging marker (o-PS) for cardiovascular imaging. This method opens the new perspective to facilitate the quantitative in vivo assessment of intracardiac masses on a molecular (nanoscale) level.
J-PET detection modules based on plastic scintillators for performing studies with positron and positronium beams
S. Sharma, J. Baran, R.S. Brusa, R. Caravita, N. Chug, A. Coussat, C. Curceanu, E. Czerwinski, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, B.C. Hiesmayr, K. Kacprzak, L. Kaplon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien D. Kumar, S. Mariazzi, S. Niedźwiecki, L. Panasa, S. Parzych, L. Povolo, E. Perez del Rio, L. Raczynski Shivani, R.Y. Shopa, M. Skurzok, E.L. Stepien, F. Tayefi, K. Tayefi, W. Wislicki and P. Moskal
abstract
The J-PET detector, which consists of inexpensive plastic scintillators, has demonstrated its potential in the study of fundamental physics. In recent years, a prototype with 192 plastic scintillators arranged in 3 layers has been optimized for the study of positronium decays. This allows performing precision tests of discrete symmetries (C, P, T) in the decays of positronium atoms. Moreover, thanks to the possibility of measuring the polarization direction of the photon based on Compton scattering, the predicted entanglement between the linear polarization of annihilation photons in positronium decays can also be studied. Recently, a new J-PET prototype was commissioned, based on a modular design of detection units. Each module consists of 13 plastic scintillators and can be used as a stand-alone, compact and portable detection unit. In this paper, the main features of the J-PET detector, the modular prototype and their applications for possible studies with positron and positronium beams are discussed. Preliminary results of the first test experiment performed on two detection units in the continuous positron beam recently developed at the Antimatter Laboratory (AML) of Trento are also reported.
TOF MLEM Adaptation for the Total-Body J-PET with a Realistic Analytical System Response Matrix
R.Y. Shopa, J. Baran, K. Klimaszewski, W. Krzemień, L. Raczyński, W. Wiślicki, K. Brzeziński, N. Chug, A. Coussat, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, B.C. Hiesmayr, E. Kavya Valsan, G. Korcyl, T. Kozik, D. Kumar, Ł. Kapłon, G. Moskal, S. Niedźwiecki, D. Panek, S. Parzych, E. Pérez del Rio, A. Ruciński, S. Sharma, Shivani, M. Silarski, M. Skurzok, E. Stepień, F. Tayefi Ardebili, K. Tayefi Ardebili, P. Moskal
abstract
We report a study of the original image reconstruction algorithm based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM), developed for the total-body (TB) Jagiellonian PET (J-PET) scanners. The method is applicable to generic cylindrical or modular multi-layer layouts and is extendable to multi-photon imaging. The system response matrix (SRM) is represented as a set of analytical functions, uniquely defined for each pair of plastic scintillator strips used for the detection. A realistic resolution model (RM) in detector space is derived from fitting the Monte Carlo simulated emissions and detections of annihilation photons on oblique transverse planes. Additional kernels embedded in SRM account for TOF, parallax effect and axial smearing. The algorithm was tested on datasets, simulated in GATE for the NEMA IEC and static XCAT phantoms inside a 24-module 2-layer TB J-PET. Compared to the reference TOF MLEM with none or a shift-invariant RM, an improvement was observed, as evaluated by the analysis of image quality, difference images and ground truth metrics. We also reconstructed the data with additive contributions, pre-filtered geometrically and with non-TOF scatter correction applied. Despite some deterioration, the obtained results still capitalise on the realistic RM with better edge preservation and superior ground truth metrics. The envisioned prospects of the TOF MLEM with analytical SRM include its application in multi-photon imaging and further upgrade to account for the non-collinearity, positron range and other factors.
Investigation of novel preclinical Total Body PET designed with J-PET technology: A simulation study
M. Dadgar, S. Parzych, F. Tayefi Ardebili, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, K. Dulski, K. Eliyan, A. Gajos, B.C. Hiesmayr, K. Kacprzak, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, L. Raczyński, S. Sharma, R.Y. Shopa, M. Skurzok, K. Tayefi Ardebili, S. Vandenberghe, W. Wiślicki, E.Ł. Stępień, P. Moskal
abstract
The growing interest in human-grade Total Body PET systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment monitoring, animalbased research became a necessary step for testing and protocol preparation. In this simulation-based study two unconventional, cost effective small animal Total Body PET scanners (for mouse and rat studies) have been investigated in order to inspect their feasibility for preclinical research. They were designed with the novel technology explored by the Jagiellonian PET Collaboration (J-PET). Two main PET characteristics: sensitivity and spatial resolution were mainly inspected to evaluate their performance. Moreover, the impact of the scintillator dimension and time-offlight on the latter parameter were examined in order to design the most efficient tomographs. The presented results show that for mouse TB J-PET the achievable system sensitivity is equal to 2.35% and volumetric spatial resolution to 9.46 +- 0.54 mm3, while for rat TB J-PET they are equal to 2.6% and 14.11 ? 0.80 mm3, respectively. Furthermore, it was shown that the designed tomographs are almost parallax-free systems, hence they resolve the problem of the acceptance criterion trade-off between enhancing spatial resolution and reducing sensitivity.
Experience and new prospects of PET imaging for ion beam therapy monitoring
K. Parodi, T. Yamaya, P. Moskal
abstract
Pioneering investigations on the usage of positron-emission-tomography (PET) for the monitoring of ion beam therapy with light (protons, helium) and heavier (stable and radioactive neon, carbon and oxygen) ions started shortly after the first realization of planar and tomographic imaging systems, which were able to visualize the annihilation of positrons resulting from irradiation induced or implanted positron emitting nuclei. And while the first clinical experience was challenged by the utilization of instrumentation directly adapted from nuclear medicine applications, new detectors optimized for this unconventional application of PET imaging are currently entering the phase of (pre)clinical testing for more reliable monitoring of treatment delivery during irradiation. Moreover, recent advances in detector technologies and beam production open several new exciting opportunities which will not only improve the performance of PET imaging under the challenging conditions of in-beam applications in ion beam therapy, but will also likely expand its field of application. In particular, the combination of PET and Compton imaging can enable the most efficient utilization of all possible radiative emissions for both stable and radioactive ion beams, while positronium lifetime imaging may enable probing new features of the underlying tumour and normal tissue environment. Thereby, PET imaging will not only provide means for volumetric reconstruction of the delivered treatment and in-vivo verification of the beam range, but can also shed new insights for biological optimization of the treatment or treatment response assessment.
Testing Discrete Symmetries in Ortho-Positronium Decays with the J-PET Detector
E. Czerwiński
abstract
A first result related to a CPT test in the decay of ortho-positronium based on data collected by means of the J-PET detector is already available, and a new test of CP symmetry is under investigation. Both results are based on the determination of angular correlations between momenta of gamma rays and other vector properties of the investigated system. Here, arguments for the possible usage of data collected by the J-PET group to test CPT symmetry within the Standard-Model Extension framework are shortly presented.
A modular data acquisition system for reconstruction of radiation dose spatial distribution in radiotherapy treatment planning
P. Jurgielewicz, M. Filipek, T. Fiutowski, D. Kabat, K. Kalecińska, Ł. Kapłon, M. Kopeć, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, T. Szumlak, B. Mindur
abstract
In this work we propose the complete Data Acquisition (DAQ) system for measurement of volumetric radiotherapeutic dose deposition in tissue-like phantoms based on 3D printed plastic scintillators. The DAQ is easily extensible thanks to the modular architecture of its hardware and software components. We show results from the full measurement chain indicating proper operation of the system.
A reconfigurable detector for measuring the spatial distribution of radiation dose for applications in the preparation of individual patient treatment plans
M. Kopeć, T. Fiutowski, P. Jurgielewicz, D. Kabat, K. Kalecińska, Ł. Kapłon, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, T. Szumlak, B. Mindur
abstract
In this work, a novel reconfigurable Dose-3D detector intended for a full spatial therapeutic dose measurement to improve radiotherapy treatment planning is presented. The device is composed of a reconfigurable detection phantom allowing patient-centric adjustments to its geometry, a scalable data acquisition system (including hardware, firmware, and low-level software) designed to change with the phantom?s configuration seamlessly, and a high-level software package for tumour geometry extraction based on computer tomography scans. Extracted geometry will be used in the Monte Carlo simulations and the configuration of the phantom. Each of the components to be used in the measurement system has been assessed obtaining the following results. The scintillating voxels? light output is sufficient. The data acquisition system with its hardware and software has been tested using artificial testing signals and laser light proving a reliable and robust means of physics data reconstruction.
Medical imaging data analysis using 3D deep learning models towards improving the individual treatment plans
K. Kalecińska, T. Fiutowski, P. Jurgielewicz, D. Kabat, B. Rachwał, Ł. Kapłon, M. Kopeć, S. Koperny, D. Kulig, J. Moroń, G. Moskal, A. Ruciński, P. Wiącek, B. Mindur, T. Szumlak
abstract
This work is a part of a research project aiming at delivering the next generation active medical phantom, Dose-3D, with high spatial granulation for quasi-real time measurement of the volumetric radiotherapeutic dose deposited during photon therapy. The preliminary results, discussed here, pertain to the intelligent medical data augmentation using Generative Adversarial Networks (GANs) technique implemented inside MONAI framework. However, in the scope of the project, we perform a broad search for the most efficient and advanced Deep Learning (DL) models to create tools for 3D Computed Tomography (CT) images segmentation and cancer diagnosis improvement that will be an integral part of the custom designed software platform for processing data collected with Dose-3D phantom. Apart from the innovative detection system the software itself may prove to be disruptive in the context of the currently available tools by offering open-source high quality toolkit for wide use in everyday clinical applications.
Transcriptomic data analysis of melanocytes and melanoma cell lines of LAT transporter genes for precise medicine
M. Szczepanek, D. Panek, M. Przybyło, P. Moskal, E. Stępień
abstract
Background: Boron Neutron Capture Therapy (BNCT) is a two-step treatment that can be used in some types of cancers. It involves administering a compound containing boron atoms to the patient and irradiating the affected area of the body with a neutron beam. The success of the therapy depends mainly on the delivery of the boron isotope (10B) to the tumor using an appropriate boron carrier. One of the boron carriers used is boronophenylalanine (BPA). Therefore, in research on the use of boron carriers, it is also important to know the mechanisms of its uptake by cells. Aim: To study the expression of LAT family genes in two melanoma (high melanotic WM115 and low melanotic WM266-4) cell lines and melanocytes (HEMa-Lp) which are responsible for the transport the BPA into cells. Methods: To normalize data from the transcriptomic analysis, the ratio of the median method was used. This allowed the samples to be compared with each other. Comparison metrics included log-fold change (LFC) values. The heatmap of LFC values and the cluster map were created. These graphs show the similarities and differences between the samples. Results: Transcriptomic data show that in melanocytes, LFC for SLC7A5 (LAT1) and SLC3A2 (4Fhc) was higher than in melanoma cell lines, which corresponded with their melanin content. Conclusion: Our results indicate overexpression of BPA transporter genes in normal cells (melanocytes), which may suggest the highest level of these proteins in melanocytes compared to less melanotic melanoma. Therefore, for BNCT, the use of BPA as the 10B carrier will require additional qualifying tests of amino acid transporter expression for patients and specific tumors to develop a personalized BNCT.
Feasibility study of positronium application for blood clots structural characteristics
S. Moyo, P. Moskal, E. Stępień
abstract
Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material's microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (microCT) to evaluate the extracted thrombotic material's properties. microCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With microCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.
Multi-photon time-of-flight MLEM application for the positronium imaging in J-PET
R. Shopa, K. Dulski
abstract
We develop a positronium imaging method for the Jagiellonian PET (J-PET) scanners based on the time-of-flight maximum likelihood expectation maximisation (TOF MLEM). The system matrix elements are calculated on-the-fly for the coincidences comprising two annihilation and one de-excitation photons that originate from the ortho-positronium (o-Ps) decay. Using the Geant4 library, a Monte Carlo simulation was conducted for four cylindrical 22Na sources of ?+ decay with diverse o-Ps mean lifetimes, placed symmetrically inside the two JPET prototypes. The estimated time differences between the annihilation and the positron emission were aggregated into histograms (one per voxel), updated by the weights of the activities reconstructed by TOF MLEM. The simulations were restricted to include only the o-Ps decays into back-to-back photons, allowing a linear fitting model to be employed for the estimation of the mean lifetime from each histogram built in the log scale. To suppress the noise, the exclusion of voxels with activity below 2% ? 10% of the peak was studied. The estimated o-Ps mean lifetimes were consistent with the simulation and distributed quasi-uniformly at high MLEM iterations. The proposed positronium imaging technique can be further upgraded to include various correction factors, as well as be modified according to realistic o-Ps decay models.
ProTheRaMon - a GATE simulation framework for proton therapy range monitoring using PET imaging
D. Borys, J. Baran, K.W. Brzezinski, J. Gajewski, N. Chug, A. Coussat, E. Czerwiński, M. Dadgar, K. Dulski, K. Valsan Eliyan, A. Gajos, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, R. Kopec, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, A. John Lomax, K. McNamara, S. Niedźwiecki, P. Olko, D. Panek, S. Parzych, E. Pérez del Río, L. Raczyński, S. Sharma, S. Shivani, R.Y. Shopa, T. Skóra, M. Skurzok, P. Stasica, E. Stępień, K. Tayefi Ardebili, F. Tayefi, D. Charles Weber, C. Winterhalter, W. Wiślicki, P. Moskal, A. Rucinski
abstract
Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach: The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results: ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance: We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github.
Investigation of the light output of 3D-printed plastic scintillators for dosimetry applications
Ł. Kapłon, D. Kulig, S. Beddar, T. Fiutowski, W. Górska, J. Hajduga, P. Jurgielewicz, D. Kabat, K. Kalecińska, M. Kopeć, S. Koperny, B. Mindur, J. Moroń, G. Moskal, S. Niedźwiecki, M. Silarski, F. Sobczuk, T. Szumlak, A. Ruciński
abstract
Three-dimensional (3D) printing, specifically digital light processing (DLP) technique, can be used to manufacture plastic scintillators of any shape. The purpose of this study was to determine the light output of DLP 3Dprinted scintillators for dosimetry applications. Two types of plastic scintillators with dimensions 10 mm × 10 mm × 10 mm were fabricated using DLP 3D-printing at Hanyang University, South Korea. The light output of these DLP 3D-printed samples was measured and compared to that of a commercial plastic scintillator of the same dimensions, RP-408, produced by casting. The 3D-printed scintillators emitting violet and blue light had a lower relative light output by 49% and 43%, respectively, compared to the RP-408 reference scintillator. We also investigated three types of scintillator surface finishing methods: the original surface made by the 3D printer, a sanded surface, and a polished surface. Furthermore, three wrapping configurations were tested: bare scintillator, diffuse-type polytetrafluoroethylene tape, and specular-type enhanced specular reflector foil. Both reflector types, diffuse and specular, reflected blue light with comparable efficiency. Additionally, emission and transmission spectra of the samples were measured. Emission maxima were located at 430 nm for RP-408, and 438 and 475 nm for two 3D-printed samples. Transmittance at the wavelength of maximum emission was equal to 89% for RP-408, and 73% and 66% for the two DLP-printed samples. Although the light output of the 3D-printed scintillators was about 50% lower than that of the commercial plastic scintillator, due to characteristics of 3Dprinted plastic scintillators, i.e. fast, low-cost production, and easy customization of the printed shape, they are promising as an active part of dosimeters for use in high intensity gamma radiation fields produced by medical linear accelerators with acceptable signal-to-noise ratio level.
Radiovesicolomics - new approach in medical imaging
E.Ł. Stępień, C. Rząca, P. Moskal
abstract
This review introduce extracellular vesicles (EVs) to a molecular imaging field. The idea of modern analyses based on the use of omics studies, using highthroughput methods to characterize the molecular content of a single biological system, vesicolomics seems to be the new approach to collect molecular data about EV content, to find novel biomarkers or therapeutic targets. The use of various imaging techniques, including those based on radionuclides as positron emission tomography (PET) or single photon
emission computed tomography (SPECT), combining molecular data on EVs, opens up the new space for radiovesicolomics?a new approach to be used in theranostics.
Study of the influence of hyperglycemia on the abundance of amino acids, fatty acids, and selected lipids in extracellular vesicles using TOF-SIMS
M. E. Marzec, C. Rząca, P. Moskal, E. Ł. Stępień
abstract
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) with the Bi3+ liquid metal ion gun was used to investigate the content of lipids and amino acids (AAs) in extracellular vesicles (EVs). We induced metabolic changes in human pancreatic beta-cells by stimulation with high glucose concentrations (35 mM) and tested the hypothesis of hyperglycemia (HG) has a detrimental effect on lipids and AAs in released EV subpopulations: ectosomes and exosomes. As a result of HG treatment, selected fatty acids (FAs) such as arachidonic, myristic and palmitic acids, changed their abundance in ectosomes and exosomes. Also, intensities of the characteristic peaks for cholesterol (m/z 95.09; 147.07; 161.11; 369.45) along with the molecular ion m/z 386.37 [C27H46O+] under HG conditions, both for ectosomes and exosomes, have changed significantly. Comparative analysis of HG EVs and normoglycemic (NG) ones showed statistically significant differences in the signal intensities of four AAs: valine (m/z 72.08 and 83.05), isoleucine (m/z 86.10), phenylalanine (m/z 120.08 and 132.05) and tyrosine (m/z 107.05 and 136.09). We confirmed that ToF-SIMS is a useful technique to study selected AAs and lipid profiles in various EV subpopulations. Our study is the first demonstration of changes in FAs and AAs in exosomes and ectosomes derived from ?-cells under the influence of HG.
Perspectives on translation of positronium imaging into clinics
P. Moskal, E.Ł. Stępień
abstract
The image of positronium properties created in the patient?s body during PET examination tells about the inter- and intra-molecular structure of the tissue and the concentration of bio-active molecules in the tissue [2?4]. In this article, we advocate the opinion that total-body PET systems, thanks to their high imaging sensitivity and high time resolution, open up the prospect of translating
positronium imaging into clinics.
Decoherence Puzzle in Measurements of Photons Originating from Electron-Positron Annihilation
S. Sharma, D. Kumar, P. Moskal
abstract
The entanglement of photons originating from electron-positron annihilation has not been experimentally proven. owever, the independent experiments performed so far unanimously confirm that the correlation between the linear polarizations of back-to-back photons from electron?positron annihilation is
consistent with the assumption that these photons are entangled in the polarization. Yet, unexpectedly,
recent experiments differ as regards the correlation of polarization direction of back-to-back photons
after the decoherence induced by the scattering of one of these photons on the electron in the scattering
material. In one of the experiments, the correlation before and after the decoherence of the photon state
is the same, and in the other experiment, the scattering of one photon leads to a significant decrease
in this correlation. Here we discuss this puzzle. Decoherent states were ensured provided by forcing
one of the annihilation photons to scatter earlier before measuring the polarization correlation based
on Compton kinematics. The comparison is made between the experimental setups used for the different measurements, and the results obtained are briefly discussed, highlighting the parameters that are
important in performing such measurements. Finally, the main features of the J-PET detector are presented, along with the schemes for performing similar studies, so that the conclusive results can be used
as remarks to solve the puzzle in question. Solving the decoherence puzzle will have crucial consequences
for basic studies of entanglement, as well as for the proposed application of the photon polarization in
positron emission tomography. If the correlation of the polarization of back-to-back photons from the
electron?positron annihilation is the same before and after the scattering of these photons, then it will
not be useful for the reduction of scatter fraction in positron emission tomography diagnostics.
Mirror Matter Searches with the J-PET Detector
E. Pérez del Río, W. Krzemień, B. Kłósek
abstract
The positronium system ? a bound state of an electron and a positron ? is suitable for testing the
predictions of quantum electrodynamics, since its properties can be perturbatively calculated to high
accuracy and, unlike the hydrogen system, it is not affected by the finite size or quantum chromodynamics effects at the current level of experimental precision. Experiments searching for invisible decays
of the positronium triplet state ? the ortho-positronium ? which mainly decays to three photons, are
being conducted since they are sensitive to new physics scenarios, e.g., mirror matter, milli-charged
particles, and extra space-time dimensions. The particular case of mirror matter and its search with
the novel total-body positron emission tomography scanner at the Jagiellonian University is presented.
This J-PET is a large, high precision medical imaging tool based on plastic scintillators.
Development of the Normalization Method for the Jagiellonian PET Scanner
A. Coussat, W. Krzemien, J. Baran, S. Parzych
abstract
This work aims at applying the theory of the component-based normalization to the Jagiellonian PET
scanner, currently under development at the Jagiellonian University. In any positron emission tomography acquisition, efficiency along a line-of-response can vary due to several physical and geometrical
effects, leading to severe artifacts in the reconstructed image. To mitigate these effects, a normalization
coefficient is applied to each line-of-response, defined as the product of several components. The specificity of the Jagiellonian PET scanner geometry is taken into account. The results obtained from the
GATE simulations are compared with the preliminary results obtained from the experimental data.
Positronium as a biomarker of hypoxia
P. Moskal and E.Ł. Stępień
abstract
In this review article, we present arguments demonstrating that the advent of high sensitivity total-body PET systems and the invention of the method of positronium imaging, open realistic perspectives for the application of positronium as a biomarker forin-vivo assessment of the degree of hypoxia. Hypoxia is a state or condition, in which the availability of oxygen is not sufficient to support physiological processes in tissue and organs. Positronium is a meta-stable atom formed from electron and positron which is copiously produced in the intramolecular spaces in the living organisms undergoing positron emission tomography (PET). Properties of positronium, such as e.g., lifetime, depend on the size of intramolecular spaces and the concentration in them of oxygen molecules. Therefore, information on the partial pressure of oxygen (pO2) in the tissue may be derived from the positronium lifetime measurement. The partial pressure of oxygen differs between healthy and cancer tissues in the range from 10 to 50 mmHg. Such differences of pO2 result in the change of ortho-positronium lifetime e.g., in water by about 2?7 ps. Thus, the application of positronium as a biomarker of hypoxia requires the determination of the mean positronium lifetime with the resolution in the order of2 ps. We argue that such resolution is in principle achievable for organ-wise positronium imaging with the total-body PET systems.
New trends in theranostics
P. Moskal, E.Ł. Stępień
abstract
Novel biomarker and drug delivery systems for theranostics-extracellular vesicles
E.Ł. Stępień, C. Rząca, P. Moskal
abstract
Extracellular vesicles (EVs) are nano- and micro-sized double-layered membrane entities derivedfrom most cell types and released into biological fluids. Biological properties (cell-uptake, biocompatibility), and chemical (composition, structure) or physical (size, density) characteristics make EVs a good candidate for drug delivery systems (DDS). Recent advances in the field of EVs (e.g., scaling-up production, purification) and developments of new imaging methods (total-body positron emission tomography [PET]) revealed benefits ofradio labeled EVs in diagnostic and interventional medicine as a potential DDs in theranostics.
Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine
A. Alavi, T.J. Werner, E.Ł. Stępień, P. Moskal
abstract
Positron emission tomography (PET) imaging is the most quantitative modality for assessing diseaseactivity at the molecular and cellular levels, and therefore, it allows monitoring its course and determining the efficacy of various therapeutic interventions. In this scientific communication, we describe the unparalleled and revolutionary impact of PET imaging on researchand day to day practice of medicine. We emphasize thecritical importance of the development and synthesis of novel radiotracers (starting from the enormous impactof F-Fluorodeouxyglucose (FDG) introduced by investigators at the University of Pennsylvania (PENN)) and PET instrumentation. These innovations have led to the total-body PET systems enabling dynamic and parametric molecular imaging of all organs in the body simultaneously. We also present our perspectives for future development of molecular imaging by multiphoton PET systems that will enable users to extract substantial information (owing to the evolving role of positronium imaging) about the related molecular and biological bases of various disorders, which are unachievable by the current PET imaging techniques.
Positronium imaging with the novel multiphoton PET scanner
P. Moskal, K. Dulski, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, J. Gajewski, A. Gajos, G. Grudzień, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, H. Karimi, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, P. Małczak, S. Niedźwiecki, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński, J. Raj, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E.Ł. Stępień, M. Szczepanek, F. Tayefi, W. Wiślicki
abstract
In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient?s body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O2; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do not allow acquisition of positronium images. This study presents a new method that enables positronium imaging by simultaneous registration of annihilation photons and deexcitation photons from pharmaceuticals labeled with radionuclides. The first positronium imaging of a phantom built from cardiac myxoma and adipose tissue is demonstrated. It is anticipated that positronium imaging will substantially
enhance the specificity of PET diagnostics.
Optimisation of the event-based TOF filtered back-projection for online imaging in total-body J-PET
R.Y. Shopa, K. Klimaszewski, P. Kopka, P. Kowalski, W. Krzemień, L. Raczyński, W. Wiślicki, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, D. Kisielewska, G. Korcyl, N. Krawczyk, E. Kubicz, Sz. Niedźwiecki, J. Raj, S. Sharma, Shivani, E.Ł. Stępień, F. Tayefi, P. Moskal
abstract
We perform a parametric study of the newly developed time-of-flight (TOF) image reconstruction algorithm, proposed for the real-time imaging in total-body Jagiellonian PET (J-PET) scanners. The asymmetric 3D filtering kernel is applied at each most likely position of electron-positron annihilation, estimated from the emissions of back-to-back gamma-photons. The optimisation of its parameters is studied using Monte Carlo simulations of a 1-mm spherical source, NEMA IEC and XCAT phantoms inside the ideal J-PET scan- ner. The combination of high-pass filters which included the TOF filtered back-projection (FBP), resulted in spatial resolution, 1.5 times higher in the axial direction than for the conventional 3D FBP. For real- istic 10-minute scans of NEMA IEC and XCAT, which require a trade-offbetween the noise and spatial resolution, the need for Gaussian TOF kernel components, coupled with median post-filtering, is demon- strated. The best sets of 3D filter parameters were obtained by the Nelder-Mead minimisation of the mean squared error between the resulting and reference images. The approach allows training the recon- struction algorithm for custom scans, using the IEC phantom, when the temporal resolution is below 50 ps. The image quality parameters, estimated for the best outcomes, were systematically better than for the non-TOF FBP.
Testing CPT symmetry in ortho-positronium decays with positronium annihilation tomography
P. Moskal, A. Gajos, M. Mohammed, J. Chhokar, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, M. Gorgol, J. Goworek, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, S. Niedźwiecki, S. Parzych, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, S. Choudhary, R. Shopa, A. Sienkiewicz, M. Silarski, M. Skurzok, E. Stepien, F. Tayefi, W. Wiślicki
abstract
Charged lepton system symmetry under combined charge, parity, and time-reversal transformation (CPT) remain scarcely tested. Despite stringent quantum-electrodynamic limits, discrepancies in predictions for the electron-positron bound state (positronium atom) motivate further investigation, including fundamental symmetry tests. While CPT noninvariance effects could be manifested in non-vanishing angular correlations between final-state photons and spin of annihilating positronium, measurements were previously limited by the knowledge of the latter. Here, we demonstrate tomographic reconstruction techniques applied to three-photon annihilations of ortho-positronium atoms to estimate their spin polarisation without a magnetic field or polarised positronium source. We use a plastic-scintillator-based positron-emission-tomography scanner to record ortho-positronium (o-Ps) annihilations with a single-event estimation of o-Ps spin and determine the complete spectrum of an angular correlation operator sensitive to CPT-violating effects. We find no violation at the precision level of 10^{-4}, with an over threefold improvement on the previous measurement.
Blue-emitting polystyrene scintillators for plastic scintillation dosimetry
Ł. Kapłon, G. Moskal
abstract
Objectives: Purpose of this research was to find the best blue-emitting fluorescent substance for plastic scintillator used for gamma radiation dosimetry. Scintillator should convert gamma radiation into blue light with high efficiency.
Methods: Plastic scintillators with fixed concentration of various fluorescent additives, called wavelength shifters, absorbing ultraviolet light and emitting blue light were manufactured by radical bulk polymerization of styrene. Light output were measured and compared to the light output of commercial plastic scintillator.
Results: Performed measurements of charge Compton spectra confirmed usefulness of majority of researched substances as wavelength shifters in plastic scintillators with emission maximum at blue range of visible light.
Conclusions: Plastic scintillation dosimeter may be constructed from manufactured polystyrene-based scintillators. Performance of synthesized scintillators is close to commercial polystyrene scintillators.
Simulating NEMA characteristics of the modular total-body J-PET scanner - an economic total-body PET from plastic scintillators
P. Moskal, P. Kowalski, R.Y. Shopa, L. Raczyński, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, A. Gajos, B.C. Hiesmayr, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, P. Kopka, G. Korcyl, N. Krawczyk, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, Sz. Parzych, J. Raj, S. Sharma, S. Shivani, E. Stępień, F. Tayefi, W. Wiślicki
abstract
The purpose of the presented research is the estimation of the performance characteristics of the economic total-body Jagiellonian-PET system (TB-J-PET) constructed from plastic scintillators. The characteristics are estimated according to the NEMANU-2-2018 standards utilizing the GATE package. The simulated detector consists of 24 modules, each built out of 32 plastic scintillator strips
(each with a cross-section of 6 mm times 30 mm and length of 140 or 200 cm) arranged in two layers in regular 24-sided polygon circumscribing a circle with a diameter of 78.6 cm. For the TB-J-PET with an axial field-of-view (AFOV) of 200 cm, a spatial resolution (SRs) of 3.7mm (transversal) and 4.9mm (axial) are achieved. The noise equivalent count rate (NECR) peak of 630 kcps is expected at 30 kBq cc^-1. Activity concentration and the sensitivity at the center amount to 38 cps kBq^-1. The scatter fraction (SF) is estimated to 36.2 %. The values of SF and SR are comparable to those obtained for the state-of-the-art clinical PET scanners and the first total-body tomographs: uExplorer and PennPET.With respect to the standard PET systemswithAFOVin the range from16 to 26 cm, the TBJ-PET is characterized by an increase inNECRapproximately by a factor of 4 and by the increase of the whole-body sensitivity by a factor of 12.6 to 38. The time-of-flight resolution for the TB-J-PETis expected to be at the level ofCRT=240 ps fullwidth at half-maximum. For the TB-J-PETwith an AFOVof 140 cm, an image quality of the reconstructed images of a NEMAIEC phantom was presented with a contrast recovery coefficient and a background variability parameters. The increase of the whole-body sensitivity andNECRestimated for the TB-J-PET with respect to current commercial PETsystems makes the TB-J-PET a promising cost-effective solution for the broad clinical applications of total-body PET scanners. TB-J-PETmay constitutes an economic alternative for the crystal TB-PET scanners, since plastic scintillators are much cheaper than BGO or LYSO crystals and the axial arrangement of the strips significantly reduces the costs of readout electronics and SiPMs.
The J-PET detector - a tool for precision studies of ortho-positronium decays
K. Dulski, S.D. Bass, J. Chhokar, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B.C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K. Klimaszewski, P. Kopka, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, P. Małczak, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński7, J. Raj, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, F. Tayefi, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The J-PET tomograph is constructed from plastic scintillator strips arranged axially in concentric cylindrical layers. It enables investigations of positronium decays by measurement of the time, position, polarization and energy deposited by photons in the scintillators, in contrast to studies conducted so far with crystal and semiconductor based detection systems where the key selection of events is based on the measurement of the photons energies. In this article we show that the J-PET tomography system constructed solely from plastic scintillator detectors is capable of exclusive measurements of the decays of ortho-positronium atoms. We present the first positronium production results and its lifetime distribution measurements. The obtained results prove the capability of the J-PET tomograph for (i) fundamental studies of positronium decays (in particular test of discrete symmetries in purely leptonic systems), (ii) positron annihilation lifetime spectroscopy, as well as (iii) molecular imaging diagnostics and (iv) observation of entanglement
3D TOF-PET image reconstruction using total variation regularization
L. Raczyński, W. Wiślicki, K. Klimaszewski, W. Krzemień, P. Kopka, P. Kowalski, R. Y. Shopa, M. Bała, J. Chhokar, C. Curceanu, E. Czerwinski, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. Hiesmayr, B. Jasińska, K. Kacprzak, L. Kapłon, D. Kisielewska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, S. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, J. Raj, K. Rakoczy, A. Ruciński, S. Sharma, S. Shivani, M. Silarski, M. Skurzok, E.Ł. Stepień, B. Zgardzińska, P. Moskal
abstract
In this paper we introduce a semi-analytic algorithm for 3-dimensional image reconstruction for positron emission tomography (PET). The method consists of the back-projection of the acquired data into the most likely image voxel according to time-of-flight (TOF) information, followed by the filtering step in the image space using an iterative optimization algorithm with a total variation (TV) regularization. TV regularization in image space is more computationally efficient than usual iterative optimization methods for PET reconstruction with a full system matrix that uses TV regularization. The efficiency comes from the one-time TOF back-projection step that might also be described as a reformatting of the acquired data. An important aspect of our work concerns the evaluation of the filter operator of the linear transform mapping an original radioactive tracer distribution into the TOF back-projected image. We obtain concise, closed-form analytical formula for the filter operator. The proposed method is validated with the Monte Carlo simulations of the NEMA IEC phantom using a one-layer, 50 cm-long cylindrical device called Jagiellonian PET scanner. The results show a better image quality compared with the reference TOF maximum likelihood expectation maximization algorithm.
A simple approach for experimental characterization and validation of proton pencil beam profiles
P. Stasica, J. Baran, C. Granja, N. Krah, G. Korcyl, C. Oancea, M. Pawlik-Niedźwiecka, Sz. Niedźwiecki, M. Rydygier, A. Schavi, A. Rucinski, J. Gajewski
abstract
A precise characterization of therapeutic proton pencil beams is essential for commissioning of any treatment planning system (TPS). The dose profile characterization includes measurement of the beam lateral dose profile in the beam core and far from the beam core, in the so called low-dose envelope, and requires a sophisticated detection system with a few orders of magnitude dynamic range. We propose to use a single-quantum sensitive MINIPIX TIMEPIX detector, along with an in-house designed holder to perform measurements of the pencil beam dose profile in air and in water. We validated the manufacturer calibration of the MINIPIX TIMEPIX detector in proton beams of various energies and compared the deposited energy spectra to Monte Carlo (MC) simulations. The precision of the lateral dose profile measurements has been systematically validated against Krakow proton facility commissioning data and dose profile simulations performed with MC codes GATE/Geant4 and FRED. We obtained an excellent agreement between MINIPIX TIMEPIX measurements and simulations demonstrating the feasibility of the system for a simple characterization and validation of proton pencil beams. The proposed approach can be implemented at any proton therapy facility to acquire experimental data needed to commission and validate analytical and MC based TPS.
Synchronisation and calibration of the 24-modules J-PET prototype with 300 mm axial field of view
P. Moskal, T. Bednarski, Sz. Niedźwiecki, M. Silarski, E. Czerwiński, T. Kozik, J. Chhokar, M. Bała, C. Curceanu, R. Del Grande, M. Dadgar, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K.Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, L. Raczyński, S. Sharma, Shivani, R. Y. Shopa, M. Skurzok, E. Stępień, W. Wiślicki, B. Zgardzińska
abstract
Research conducted in the framework of the J-PET project aims to develop a cost-effective total-body positron emission tomography scanner. As a first step on the way to construct a full-scale J-PET tomograph from long strips of plastic scintillators, a 24-strip prototype was built and tested. The prototype consists of detection modules arranged axially forming a cylindrical diagnostic chamber with an inner diameter of 360 mm and an axial field-of-view of 300 mm. Promising perspectives for a low-cost construction of a total-body PET scanner are opened due to an axial arrangement of strips of plastic scintillators, which have a small light attenuation, superior timing properties, and the possibility of cost-effective increase of the axial field-of-view. The presented prototype comprises dedicated solely digital front-end electronic circuits and a triggerless data acquisition system which required development of new calibration methods including time, thresholds and gain synchronization. The system and elaborated calibration methods including first results of the 24-module J-PET prototype are presented and discussed. The achieved coincidence resolving time equals to CRT = 490 +- 9 ps. This value can be translated to the position reconstruction accuracy s(Dl) = 18 mm which is fairly position-independent Keywords: positron emission tomography, plastic scintillators, J-PET.
Sensitivity of discrete symmetry tests in the positronium system with the J-PET detector
A. Gajos
abstract
Study of certain angular correlations in the three-photon annihilations of the triplet state of positronium, the electron?positron bound state, may be used as a probe of potential CP and CPT-violating effects in the leptonic sector. We present the perspectives of CP and CPT tests using this process recorded with a novel detection system for photons in the positron annihilation energy range, the Jagiellonian Positron Emission Tomography (J-PET). We demonstrate the capability of this system to register three-photon annihilations with an unprecedented range of kinematical configurations and to measure the CPT-odd correlation between positronium spin and annihilation plane orientation with a precision improved by at least an order of magnitude with respect to present results. We also discuss the means to control and reduce detector asymmetries in order to allow J-PET to set the first measurement of the correlation between positronium spin and momentum of the most energetic annihilation photon which has never been studied to date.
Prospects and clinical perspectives of total-body PET imaging using plastic scintillators
P. Moskal, E. Ł. Stępień
abstract
Total-body PET opens new diagnostic paradigm with prospects for personalized disease treatment, yet the high cost of the current crystal-based PET technology limits dissemination of total-body PET in hospitals and even in the research
clinics.
The J-PET tomography system is based on axially arranged low-cost plastic scintillator strips. It constitutes a realistic cost-effective solution of a total-body PET for broad clinical applications.
High sensitivity of total-body J-PET and trigger-less data acquisition enable multi-photon imaging, opening possibilities for multi-tracer and positronium imaging, thus promising quantitative enhancement of specificity in cancer and inflammatory diseases assessment.
An example of dual tracer analysis, becoming possible with total-body J-PET system, could be a concurrent application of FDA-approved 82Rb-Chloride and [18F]FDG, allowing simultaneous assessment of myocardium metabolic rate and perfusion of the cardiovascular system.
Technical Attenuation Length Measurement of Plastic Scintillator Strips for the Total-Body J-PET Scanner
Ł. Kapłon
abstract
The aim of the performed technical attenuation length measurement is to compare light attenuation of a few commercially available plastic scintillator strips and to select the best scintillator type for the total-body Jagiellonian Positron Emission Tomograph (J-PET) construction. Few models of plastic scintillators obtained from different manufacturers were tested. All strips had the same rectangular cross section and dimensions 6 mm x 24 mm x 1000 mm with all surfaces polished. The light attenuation length was measured by exciting the scintillator strip at different positions with an ultraviolet lamp emitting at 365 nm and reading light signal collected at one side of the strip by a silicon photodiode. Among measured plastic scintillators, EJ-200 possesses the highest technical light attenuation length and is suitable for construction of total-body J-PET scanner.
X-ray microtomography as a new approach for imaging and analysis of tumor spheroids
H. Karimi, B. Leszczyński, T. Kołodziej, E. Kubicz, M. Przybyło, E. Stępień
abstract
Three-dimensional (3D) spheroids mimic important properties of tumors and may soon become a reasonable
substitute for animal models and human tissue, eliminating numerous problems related to in vivo and ex vivo
experiments and pre-clinical drug trials. Currently, various imaging methods including X-ray microtomography
(micro-CT), exist but their spatial resolution is limited. Here, we visualized and provided a morphological
analysis of spheroid cell cultures using micro-CT and compared it to that of confocal microscopy. An approach is
proposed that can potentially open new diagnostic opportunities to determine the morphology of cancer cells
cultured in 3D structures instead of using actual tumors.
Spheroids were formed from human melanoma cell lines WM266-4 and WM115 seeded at different cell
densities using the hanging drop method. Micro-CT analysis of spheroid showed that spheroid size and shape
differed depending on the cell line, initial cell number, and duration of culture.
The melanoma cell lines used in this study can successfully be cultured as 3D spheroids and used to substitute
human and animal models in pre-clinical studies. The micro-CT allows for high-resolution visualization of the
spheroids structure.
State of the art in total body PET
S. Vandenberghe, P. Moskal and J.S. Karp
abstract
The idea of a very sensitive positron emission tomography (PET) system covering a large portion of the body of a patient already dates back to the early 1990s. In the period 2000-2010, only some prototypes with long axial field of view (FOV) have been built, which never resulted in systems used for clinical research. One of the reasons was the limitations in the available detector technology, which did not yet have sufficient energy resolution, timing resolution or countrate capabilities for fully exploiting the benefits of a long axial FOV design. PET was also not yet as widespread as it is today: the growth in oncology, which has become the major application of PET, appeared only after the introduction of PET-CT (early 2000).The detector technology used in most clinical PET systems today has a combination of good energy and timing resolution with higher countrate capabilities and has now been used since more than a decade to build time-of-flight (TOF) PET systems with fully 3D acquisitions. Based on this technology, one can construct total body PET systems and the remaining challenges (data handling, fast image reconstruction, detector cooling) are mostly related to engineering. The direct benefits of long axial FOV systems are mostly related to the higher sensitivity. For single organ imaging, the gain is close to the point source sensitivity which increases linearly with the axial length until it is limited by solid angle and attenuation of the body. The gains for single organ (compared to a fully 3D PET 20-cm axial FOV) are limited to a factor 3-4. But for long objects (like body scans), it increases quadratically with scanner length and factors of 10?40 × higher sensitivity are predicted for the long axial FOV scanner. This application of PET has seen a major increase (mostly in oncology) during the last 2 decades and is now the main type of study in a PET centre. As the technology is available and the full body concept also seems to match with existing applications, the old concept of a total body PET scanner is seeing a clear revival. Several research groups are working on this concept and after showing the potential via extensive simulations; construction of these systems has started about 2 years ago. In the first phase, two PET systems with long axial FOV suitable for large animal imaging were constructed to explore the potential in more experimental settings. Recently, the first completed total body PET systems for human use, a 70-cm-long system, called PennPET Explorer, and a 2-m-long system, called uExplorer, have become reality and first clinical studies have been shown. These results illustrate the large potential of this concept with regard to low-dose imaging, faster scanning, whole-body dynamic imaging and follow-up of tracers over longer periods. This large range of possible technical improvements seems to have the potential to change the current clinical routine and to expand the number of clinical applications of molecular imaging. The J-PET prototype is a prototype system with a long axial FOV built from axially arranged plastic scintillator strips.This paper gives an overview of the recent technical developments with regard to PET scanners with a long axial FOV covering at least the majority of the body (so called total body PET systems). After explaining the benefits and challenges of total body PET systems, the different total body PET system designs proposed for large animal and clinical imaging are described in detail. The axial length is one of the major factors determining the total cost of the system, but there are also other options in detector technology, design and processing for reducing the cost these systems. The limitations and advantages of different designs for research and clinical use are discussed taking into account potential applications and the increased cost of these systems.
Performance assessment of the 2gamma positronium imaging with the total-body PET scanners
P. Moskal, D. Kisielewska, Z. Bura, C. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, A. Kamińska, Ł. Kapłon, H. Karimi, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, P. Małczak, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, M. Pędziwiatr, L. Raczyński, J. Raj, A. Ruciński, S. Sharma, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, E. Ł. Stępień, S. Vandenberghe, W. Wiślicki, B. Zgardzińska
abstract
In living organisms the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511~keV photons. In this article we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include: (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using 2gamma annihilations, and (ii) estimation of the spatial and time resolution of the ortho-positronium image as a function of the coincidence resolving time (CRT) of the scanner. Simulations are conducted assuming that radiopharmaceutical is labelled with 44Sc isotope emitting one positron and one prompt gamma. The image is reconstructed on the basis of triple coincidence events. The ortho-positronium lifetime spectrum is determined for each voxel of the image. Calculations were performed for cases of total-body detectors build of (i) LYSO scintillators as used in the EXPLORER PET, and (ii) plastic scintillators as anticipated for the cost-effective total-body J-PET scanner. To assess the spatial and time resolution the three cases were considered assuming that CRT is equal to 140ps, 50ps and 10ps. The estimated total-body PET sensitivity for the registration and selection of image forming triple coincidences is larger by a factor of 12.2 (for LYSO PET) and by factor of 4.7 (for plastic PET) with respect to the sensitivity for the standard 2gamma imaging by LYSO PET scanners with AFOV=20cm.
Estimating relationship between the Time Over Threshold and energy loss by photons in plastic scintillators used in the J-PET scanner
S. Sharma, J. Chhokar, C. Curceanu, E. Czerwinski, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, N. Gupta-Sharma, R. Del Grande, B. C. Hiesmayr, B. Jasinska, K. Kacprzak, L. Kaplon, H. Karimi, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemien, E. Kubicz, M. Mohammed, Sz. Niedzwiecki, M. Palka, M. Pawlik-Niedzwiecka, L. Raczynski, J. Raj, A. Rucinski, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, E. L. Stepien, W. Wislicki, B. Zgardzinska, P. Moskal
abstract
Time-Over-Threshold (TOT) technique is being used widely due to its implications in developing the multi channel readouts mainly when fast signal processing is required. Using TOT technique as a measure of energy loss instead of charge integration methods significantly reduces the signals readout cost by combining the time and energy information. Therefore, this approach can potentially be used in J-PET tomograph which is build from plastic scintillators characterized by fast light signals. The drawback in adopting this technique is lying in the non-linear correlation between input energy loss and TOT of the signal. The main motivation behind this work is to develop the relationship between TOT and energy loss and validate it with the J-PET tomograph.
The experiment was performed using the 22Na beta emitter source placed in the center of the J-PET tomograph. One can obtain primary photons of two different energies: 511 keV photon from the annihilation of positron (direct annihilation or through the formation of para-Positronim atom or pick-off process of ortho-Positronium atoms), and 1275 keV prompt photon. This allows to study the correlation between TOT values and energy loss for energy range up to 1000 keV. As the photon interacts dominantly via Compton scattering inside the plastic scintillator, there is no direct information of primary photon energy. However, using the J-PET geometry one can measure the scattering angle of the interacting photon. Since, 22Na source emits photons of two different energies, it is required to know unambiguously the energy of incident photons and its corresponding scattering angle for the estimation of energy deposition. In this work, the relationship between Time Over Threshold and energy loss by interacting photons inside the plastic scintillators used in J-PET scanner is established for a energy deposited range 100-1000 keV.
Hit-time and hit-position reconstruction in strips of plastic scintillators using multi-threshold readouts
N. G. Sharma, M. Silarski, J. Chhokar, E. Czerwinski, C. Curceanu, K. Dulski, K. Farbaniec, A. Gajos, R. Del Grande, M. Gorgol, B. C. Hiesmayr, B. Jasinska, K. Kacprzak, L. Kaplon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemien, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedzwiecki, M. Palka, M. Pawlik-Niedzwiecka, L. Raczynski, J. Raj, S. Sharma, S. Shivani, R. Y. Shopa, M. Skurzok, W. Wislicki, B. Zgardzinska, P. Moskal
abstract
In this article a new method for the reconstruction of hit-position and hit-time of photons in long scintillator detectors is investigated. This research is motivated by the recent development of the positron emission tomography scanners based on plastic scintillators. The proposed method constitutes a new way of signal processing in Multi-Voltage-Technique. It is based on the determination of the degree of similarity between the registered signals and the synchronized model signals stored in a library. The library was established for a set of well defined hit-positions along the length of the scintillator. The Mahalanobis distance was used as a measure of similarity between the two compared signals. The method was validated on the experimental data measured using two-strips J-PET prototype with dimensions of 5x9x300 mm. The obtained Time-of-Flight (TOF) and spatial resolutions amount to 325 ps (FWHM) and 25 mm (FWHM), respectively. The TOF resolution was also compared to the results of an analogous study done using Linear Fitting method. The best TOF resolution was obtained with this method at four pre-defined threshold levels which was comparable to the resolution achieved from the Mahalanobis distance at two pre-defined threshold levels. Although the algorithm of Linear Fitting method is much simpler to apply than the Mahalanobis method, the application of the Mahalanobis distance requires a lower number of applied threshold levels and, hence, decreases the costs of electronics used in PET scanner.
J-PET Framework: Software platform for PET tomography data reconstruction and analysis
W. Krzemień, A. Gajos, K. Kacprzak, K. Rakoczy, G. Korcyl
abstract
J-PET Framework is an open-source software platform for data analysis, written in C++ and based on the ROOT package. It provides a common environment for implementation of reconstruction, calibration and filtering procedures, as well as for user-level analyses of Positron Emission Tomography data. The library contains a set of building blocks that can be combined by users with even little programming experience, into chains of processing tasks through a convenient, simple and well-documented API. The generic input-output interface allows processing the data from various sources: low-level data from the tomography acquisition system or from diagnostic setups such as digital oscilloscopes, as well as high-level tomography structures e.g. sinograms or a list of lines-of-response. Moreover, the environment can be interfaced with Monte Carlo simulation packages such as GEANT and GATE, which are commonly used in the medical scientific community.
Towards Lattice Quantum Chromodynamics on FPGA devices
G. Korcyl, P. Korcyl
abstract
In this paper we describe a single-node, double precision Field Programmable Gate Array (FPGA) implementation of the Conjugate Gradient algorithm in the context of Lattice Quantum Chromodynamics. As a benchmark of our proposal we invert numerically the Dirac-Wilson operator on a 4-dimensional grid on three Xilinx hardware solutions: Zynq Ultrascale+ evaluation board, the Alveo U250 accelerator and the largest device available on the market, the VU13P device. In our implementation we separate software/hardware parts in such a way that the entire multiplication by the Dirac operator is performed in hardware, and the rest of the algorithm runs on the host. We find out that the FPGA implementation can offer a performance comparable with that obtained using current CPU or Intel?s many core Xeon Phi accelerators. A possible multiple node FPGA-based system is discussed and we argue that power-efficient High Performance Computing (HPC) systems can be implemented using FPGA devices only.
Studies of Ortho-Positronium Decays into Three Photons with the J-PET Detector
A. Gajos on behalf of the J-PET collaboration
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) setup, besides being the first PET scanner built with plastic scintillators is currently used to conduct a broad range of experiments involving ortho-positronium (o-Ps) decays into three photons. We present results of studies of o-Ps->3g decays performed in J-PET with a view to search for angular correlations between the photons' momenta and positronium spin direction which would violate the combined CPT symmetry, scarcely tested in leptonic systems. To date, the most precise CPT test using ortho-positronium decays reached the precision of 3×10-3 whereas effects limiting the sensitivity are only expected at the level of 10-9. In the discussed J-PET measurement, ortho-positronium atoms are created by positrons from a 22Na source thermalizing in an extensive-size cylindrical target of mesoporous silica and decay positions are reconstructed using a trilateration-based technique. Decay photons are recorded by 192 strips of plastic scintillators with high timing resolution. Such a setup allows for registration of an unprecedented spectrum of geometrical configurations of o-Ps->3g decays including also correlations with positronium spin. With an angular resolution and o-Ps polarization control improved with respect to previous measurements, J-PET aims at achieving the sensitivity of CPT test at a precision level of at least 10-4.
Synthesis and Characterization of Plastic Scintillators for the Total-body J-PET Scanner
Ł. Kapłon
abstract
The aim of the research was to develop polystyrene scintillator for use in the novel time-of-flight Jagiellonian Positron Emission Tomography (J-PET) scanner being elaborated for the whole-body imaging. To achieve this goal, polystyrene based plastic scintillators with the different chemical compositions were produced and characterized. Light output, decay time and emission spectra were measured to develop best composition of polystyrene scintillator.
Simulation of Positronium Decays in View of Charge Conjugation Symmetry Test with the J-PET Detector
J. Chhokar on behalf of the J-PET Collaboration
abstract
We present search of the C-forbidden decays of positronium with the J-PET detector. J-PET is a first
tomograph based on plastic scintillators and, due to large acceptance and high angular resolution, it is suitable for
studies of various phenomena such as: discrete symmetries in decays of positronium atom or entangled states of
photons as well as the medical imaging. In view of the C-symmetry test, the J-PET is used inter alia to determine
the angular distribution of the three annihilation photons from positronium decay.
Development of J-PEM for Breast Cancer Detection
Shivani, E. Łuczynska, S. Heinze and P. Moskal
abstract
A detection system of the conventional PET tomograph is set-up to record data from e+e- annihilation
into two photons, each with energy of 511 keV, and to give information about the spatial density distribution of
a radiopharmaceutical in the patients body. Dedicated positron emission mammography (PEM) systems provide
a potentially high sensitivity, high-resolution, low attenuation, and lower cost alternative to whole body PET.
We have designed, built, and performed initial evaluation of a large field-of-view Jagiellonian Positron Emission
Mammography (J-PEM) system. This 3D system is based on novel idea of applying plastic scintillators to detect
annihilation photons and improving spatial resolution by utilization of wavelength shifters (WLS). In addition,
this device is being developed in view of classification of malignancy based on the possibility of positronium mean
lifetime imaging. Here we present the first results from the simulations as motivation for our investigation.
J-PET Monte Carlo Simulations for Time-Reversal Symmetry Test in Ortho-Positronium Decay
J. Raj, D. Kisielewska and E. Czerwiński
abstract
This article reports the development of Monte Carlo simulations of the J-PET detector using the Geant4 toolkit
aimed at serving as a foundation for testing the time-reversal symmetry in the decay of ortho-Positronium (o-Ps)
atoms. In order to observe asymmetries in time-reversal, it is important to understand the physical proper-
ties of the signal candidates (o-Ps->3g) recorded by the detector setup. The simulations aim at replicating
the experimental procedure of producing meta-stable triplet states of positronium and testing the T-symmetry
using symmetry-odd operators with the Jagiellonian-Positron Emission Tomograph (J-PET) detector.
TOT Method for the Disentanglement of Photons in Positron Annihilation Lifetime Spectroscopy
S. Sharma on behalf of J-PET collaboration
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is a multidisciplinary device aiming to perform studies in medical field as well as to test the fundamental symmetries. The plastic scintillators offer very good time resolution. Although, due to the low atomic number of the plastic material, the incident photons interact mainly via the Compton effect. Thus instead of full energy deposition by the photon, there is a range of energy depositions depending on its scattering angle. For the positron annihilation lifetime spectroscopy studies, it is necessary to distinguish the photons emitted from different processes. Therefore, it becomes crucial to find a method to disentangle the photons of different energies. In the present work, the control spectra are discussed which can unambiguously categorize the photons of different energies and origins, which are essential for the studies based on the positronium lifetime
PALS Avalanche - A New PAL Spectra Analysis Software
K. Dulski
abstract
A novel concept for tomography of the human body developed by the Jagiellonian Positronium EmissionTomography (J-PET) project provides the possibility to combine metabolic information collected by standardPET with structural information obtained from positronium lifetime. This results in a morphometric image. Tothis end, there is a need to develop software compatible with the J-PET Framework for fast online analysis duringimaging. PALS Avalanche is a software developed on UNIX system and based on ROOT software, which allows oneto decompose positronium annihilation lifetime spectra in the form of a set of single time differences and histogram.Performance of the PALS Avalanche will be tested by analysing simulated PAL spectra.
Studies of the ortho-Positronium lifetime for cancer diagnostics
Z. Bura, K. Dulski, E. Kubicz, P. Małczak, M. Pędziwiatr, M. Szczepanek, E.Ł. Stępień, P. Moskal
abstract
Positron Annihilation Lifetime Spectroscopy (PALS) is a technique based on the analysis of the lifetime of positronium emitted from implanted or delivered positronium donors. This technique employs the lifetime and intensity dependence on the structure of analyzed material. Due to this specific features, PALS might be used in further research protocols and clinical studies for cancer diagnostic purposes. This article reports the progress in the study design, main objectives of the study, protocols of measurement sand data analysis and further perspective of this study. The main goal of this work was to show the effectiveness of this method and progress in its development. For this purpose, colorectal cancer was examined.
Application of silicon-polymer composite varistors to protect sensitive medical imaging circuits and performing better voltage bias for SiPMs
F. Tayefi Ardebili, M. Ghafouri
abstract
Nowadays, Silicon photomultipliers (SiPM) become a reasonable choice
for Time-of-Flight Positron Emission Tomography (TOF-PET). To achieve
the best performance of SiPMs, it is necessary to adjust a suitable voltage
bias. In this article, we are using varistors which protect SiPM from voltage
fluctuations. The silicon-polymer composite varistors prepared using hot
press method have been investigated. Research on (current-voltage) characteristics of samples shows that by increasing silicon content in the mixture, the breakdown voltage decreases from 110 V to 70 V. The results also
show that increasing silicon content decreases the potential barrier height
from 0.29 eV to 0.26 eV, however, leakage current increases. Increasing
silicon content increases nonlinear coefficient from 4.1 to 4.8. Using these
techniques gives us ability to produce suitable surge protector for medical
imaging modalities.
Gate simulation study of the 24-module J-PET scanner: data analysis and image reconstruction
M. Dadgar, P. Kowalski, for the J-PET Collaboration
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is a novel PET
device that, in contrast to commercial PET scanners, is based on plastic
scintillator strips. Modular J-PET is the latest prototype that consists
of 24 modules arranged in a cylinder. In this study, 6 point-like sources
defined in the NEMA spatial resolution standard were simulated twice with
total activities of 60 kBq and 60 MBq, respectively. Results of simulations
were processed with the GOJA software and reconstructed with the QETIR
package
A Method for Time Calibration of PET Systems Using Fixed beta+ Radioactive Source
K. Dulski, M. Silarski, P. Moskal
abstract
The Positron Emission Tomography (PET) is one of the most popular imaging techniques of the human body. During the PET scans, a positron from the beta+ emitter given to the patient, directly or after forming a positronium, annihilates with an electron from the patient, with emission of photons. Registration of produced photons allows one to reconstruct the distribution of radioisotopes in the patient's body, further interpreted as the metabolic image. The imaging of metabolism can be improved by measurement of the time difference between registration of the two photons in coincidence (Time-of-Flight (TOF))[1]. In the case of the TOF-PET scanners, the time resolution of the detection system and its calibration is crucial. The Jagiellonian Positron Emission Tomograph (J-PET) detector is an example of the TOF-PET system, constructed at the Jagiellonian University in Kraków, which is based on plastic scintillators and very fast electronics
Melanoma spheroids as a model for cancer imaging study
E. Ł. Stępień, H. Karimi, B. Leszczyński, M. Szczepanek
abstract
In contrast to standard 2D cell cultures, spheroids are three-dimensional (3D) models which can mimic natural conditions of cancer growth and metabolism. Their complex structure can be investigated and analyzed using fluorescence microscopy and micro-tomographic imaging (micro-CT) as a new technique. In this study, we show application of two different melanoma cell lines (WM115 and WM266) with different biological characteristics to form spheroids by a hanging drop method.
Construction of the Vacuum Chambers for J-PET Experiments with Positron Annihilation
Marek Gorgol, Bożena Jasińska, Marek Kosior, Eugeniusz Stępień, Paweł Moskal
abstract
Vacuum chambers are necessary for the physics experiments planned to be carried out with the use of the J-PET detector. Two chambers manufactured and used for particular runs of experiments had generally cylindrical shapes, while the radioactive source was placed in the center of each chamber. The highly porous material, used as a target in which positrons positronium atoms annihilate, was placed in the immediate vicinity of the source. Such orientation ensures the axially symmetrical response of J-PET scintillators and allows to carry out correct calibration. The variation of material used for manufacturing of the chambers (aluminum/plastic), allows to observe the detector response with various rates of absorption and scattering of annihilation quanta. Such determination is necessary for proper analysis of multi-quanta annihilation, which will be needed for planned experiments.
Investigations on physical and biological range uncertainties in Krakow proton beam therapy centre
A. Rucinski, J. Baran, G. Battistoni, A. Chrostowska, M. Durante, J. Gajewski, M. Garbacz, K. Kisielewicz, N. Krah, V. Patera, M. Pawlik-Niedźwiecka, I. Rinaldi, B. Rozwadowska-Bogusz, E. Scifoni, A. Skrzypek, F. Tommasino, A. Schiavi, P. Moskal
abstract
Physical and biological range uncertainties limit the clinical potential of Proton Beam Therapy (PBT). In this proceedings, we report on two research projects, which we are conducting in parallel and which both tackle the problem of range uncertainties. One aims at developing software tools and the other at developing detector instrumentation. Regarding the first, we report on our development and pre-clinical application of a GPU-accelerated Monte Carlo (MC) simulation toolkit Fred. Concerning the letter, we report on our investigations of plastic scintillator based PET detectors for particle therapy delivery monitoring. We study the feasibility of Jagiellonian-PET detector technology for proton beam therapy range monitoring by means of MC simulations of the beta+ activity induced in a phantom by proton beams and present preliminary results of PET image reconstruction. Using a GPU-accelerated Monte Carlo simulation toolkit Fred and plastic scintillator based PET detectors we aim to improve patient treatment quality with protons.
Towards time reversal symmetry test with o-PS decays using the J-PET detector
J. Raj, K. Dulski, E. Czerwiński
abstract
One of the features of the triplet state of positronium (ortho-positronium) atoms is its relatively longer lifetime when compared to the singlet states of positronium (para-positronium) atoms. The most probable decay of orthopositronium is into three annihilation photons. In order to test the discrete symmetry using the time-reversal symmetry odd-operator, it is important to identify ortho-positronium decay. Identification of the decay of orthopositronium atoms by measuring the positronium annihilation lifetime with the Jagiellonian-Positron Emission Tomograph (J-PET) is presented in this article.
Feasibility of Ortho-positronium Lifetime Studies with the J-PET Detector in Context of Mirror Matter Models
W. Krzemien, E. Pérez del Río, K. Kacprzak
abstract
We discuss the possibility to perform the experimental searches for invisible decays in the ortho-positronium system with the J-PET detector.
Feasibility study of the positronium imaging with the J-PET tomograph
P. Moskal, D. Kisielewska, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, G. Korcyl, P. Kowalski, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E. Stępień, W. Wiślicki, B. Zgardzińska
abstract
A detection system of the conventional PET tomograph is set-up to record data from e+ e- annihilation into two photons with energy of 511 keV, and it gives information on the density distribution of a radiopharmaceutical in the body of the object. In this paper we explore the possibility of performing the three gamma photons imaging based on ortho- positronium annihilation, as well as the possibility of positronium average lifetime imaging with the J-PET tomograph constructed from plastic scintillators. For this purposes simulations of the ortho-positronium formation and its annihilation into three photons were performed taking into account distributions of photons' momenta as predicted by the theory of quantum electrodynamics and the response of the J-PET tomograph. In order to test the proposed ortho-positronium lifetime image reconstruction method, we concentrate on the decay of the ortho-positronium into three photons and applications of radiopharmaceuticals labeled with isotopes emitting a prompt gamma quantum. The proposed method of imaging is based on the determination of hit-times and hit-positions of registered photons which enables the reconstruction of the time and position of the annihilation point as well as the lifetime of the ortho-positronium on an event-by-event basis. We have simulated the production of the positronium in a cylindrical phantom composed of a set of different materials in which the ortho-positronium lifetime varied from 2 ns to ~2.9 ns, as expected for ortho-positronium created in the human body. The presented reconstruction method for total-body J-PET like detector allows to achieve a mean lifetime resolution of about 40 ps. Recent Positron Annihilation Lifetime Spectroscopy measurements of cancerous and healthy uterine tissues show that this sensitivity may allow to study the morphological changes in cell structures.
Simulation studies of annihilation-photon's polarisation via Compton scattering with the J-PET tomograph
N. Krawczyk, B.C. Hiesmayr, J. Chhokar, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. Jasińska, D. Kisielewska, G. Korcyl, P. Kowalski, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
J-PET is the first positron-emission tomograph (PET) constructed from plastic scintillators. It was optimized for the detection of photons from electron-positron annihilation. Such photons, having an energy of 511 keV, interact with electrons in plastic scintillators predominantly via the Compton effect. Compton scattering is at most probable at an angle orthogonal to the electric field vector of the interacting photon. Thus registration of multiple photon scatterings with J-PET enables to determine the polarization of the annihilation photons. In this contribution we present estimates on the physical limitation in the accuracy of the polarization determination of 511 keV photons with the J-PET detector.
Investigating the Dirac Operator Evaluation with FPGAs
G. Korcyl, P. Korcyl
abstract
In recent years, computational capacity of single Field Programmable Gate Array (FPGA) devices as well as their versatility have increased signifcantly. Adding to that fact, the High Level Synthesis frameworks allowing to program such processors in a high-level language like C++, makes modern FPGA devices a serious candidate as building blocks of a general-purpose High Performance Computing solution. In this contribution we describe benchmarks which we performed using a kernel from the Lattice QCD code, a highly compute-demanding HPC academic code for elementary particle simulations on the newest device from Xilinx, the U250 accelerator card. We describe the architecture of our solution and benchmark its performance on a single FPGA device running in two modes: using either external or embedded memory. We discuss both approaches in detail and provide assessment for the necessary memory throughput and the minimal amount of resources needed to deliver optimal performance depending on the available hardware. Our considerations can be used as guidelines for estimating the performance of some larger, manynode systems.
Positronium in medicine and biology
P. Moskal, B. Jasińska, E. Ł. Stępień, S. D. Bass
abstract
In positron emission tomography, as much as 40% of positron annihilation occurs through the production of positronium atoms inside the patient's body. The decay of these positronium atoms is sensitive to metabolism and could provide information about disease progression. New research is needed to take full advantage of what positronium decays reveal.
Feasibility studies of the polarization of photons beyond the optical wavelength regime with the J-PET detector
P. Moskal, N. Krawczyk, B. C. Hiesmayr, M. Bała, C. Curceanu, E. Czerwinski, K. Dulski, A. Gajos, M. Gorgol, R. Del Grande, B. Jasinska, K. Kacprzak, L. Kapłon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemien, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczynski, J. Raj, Z. Rudy, S. Sharma, M. Silarski, Shivani, R. Y. Shopa, M. Skurzok, W. Wislicki, B. Zgardzinska
abstract
J-PET is a detector optimized for registration of photons from the electron-positron annihilation via plastic scintillators where photons interact predominantly via Compton scattering. Registration of both primary and scattered photons enables to determinate the linear polarization of the primary photon on the event by event basis with a certain probability. Here we present quantitative results on the feasibility of such polarization measurements of photons from the decay of positronium with the J-PET and explore the physical limitations for the resolution of the polarization determination of 511keV photons via Compton scattering. For scattering angles of about 82 degree (where the best contrast for polarization measurement is theoretically predicted) we find
that the single event resolution for the determination of the polarization is about 40 degree (predominantly due to properties
of the Compton effect). However, for samples larger than ten thousand events the J-PET is capable of determining relative average polarization of these photons with the precision of about few degrees. The obtained results open new perspectives for studies of various physics phenomena such as quantum entanglement and tests of discrete symmetries in decays of positronium and extend the energy range of polarization measurements by five orders of magnitude beyond the optical wavelength regime.
Evaluation of Single-Chip, Real-Time Tomographic Data Processing on FPGA - SoC Devices
G. Korcyl, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, B. Flak, A. Gajos, B. Głowacz, M. Gorgol, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, M. Kajetanowicz, D. Kisielewska, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pawlik- Niedźwiecka, M. Pałka, L. Raczyński, P. Rajda, Z. Rudy, P. Salabura, N. G. Sharma, S. Sharma, R. Y. Shopa, M. Skurzok, M. Silarski, P. Strzempek, A. Wieczorek, W. Wiślicki, R. Zaleski, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel approach to tomographic data processing
has been developed and evaluated using the Jagiellonian PET (J-
PET) scanner as an example. We propose a system in which there
is no need for powerful, local to the scanner processing facility,
capable to reconstruct images on the fly. Instead we introduce a
Field Programmable Gate Array (FPGA) System-on-Chip (SoC)
platform connected directly to data streams coming from the
scanner, which can perform event building, filtering, coincidence
search and Region-Of-Response (ROR) reconstruction by the
programmable logic and visualization by the integrated
processors. The platform significantly reduces data volume
converting raw data to a list-mode representation, while
generating visualization on the fly.
A feasibility study of the time reversal violation test based on polarization of annihilation photons from the decay of ortho-Positronium with the J-PET detector
J. Raj, A. Gajos, C. Curceanu, E. Czerwiński, K. Dulski, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, K. Rakoczy, Z. Rudy, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is a novel device being developed at Jagiellonian University in Krakow, Poland based on organic scintillators. J-PET is an axially symmetric and high acceptance scanner that can be used as a multi-purpose detector system. It is well suited to pursue tests of discrete symmetries in decays of positronium in addition to medical
imaging. J-PET enables the measurement of both momenta and the polarization vectors of annihilation photons. The latter is a unique feature of the J-PET detector which allows the study of time reversal symmetry violation operator which can be constructed solely from the annihilation photons momenta before and after the scattering in the detector.
Commissioning of the J-PET detector in view of the positron annihilation lifetime spectroscopy
K. Dulski, C. Curceanu, E. Czerwiński, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, Shivani, R. Y. Shopa, M. Silarski, M. Skurzok, W. Wiślicki, B. Zgardzińska, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET device built from plastic scintillators. It is a multi-purpose detector designed for medical imaging and for studies of properties of positronium atoms in porous matter and in living organisms. In this article we report on the commissioning of the J-PET detector in view of studies of positronium decays. We present results of analysis of the positron lifetime measured in the porous polymer. The obtained results prove that J-PET is capable of performing simultaneous imaging of the density distribution of annihilation points as well as positron annihilation lifetime spectroscopy.
Estimating the NEMA characteristics of the J-PET tomograph using the GATE package
P. Kowalski, W. Wiślicki, R.Y. Shopa, L. Raczyński, K. Klimaszewski, C. Curcenau, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. Hiesmayr, B. Jasińska, Ł. Kapłon, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, S. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, S. Shivani, M. Silarski, M. Skurzok, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel whole-body positron emission tomography (PET) system based on plastic scintillators is
developed by the J-PET Collaboration. It consists of plastic scintillator strips arranged axially in the
form of a cylinder, allowing the cost-effective construction of the total-body PET system. In order to
determine the properties of the scanner prototype and optimize its geometry, advanced computer
simulations were performed using the GATE (Geant4 application for tomographic emission)
software.
The spatial resolution, sensitivity, scatter fraction and noise equivalent count rate were estimated
according to the National Electrical Manufacturers Association norm, as a function of the length
of the tomograph, the number of detection layers, the diameter of the tomographic chamber and
for various types of applied readout. For the single-layer geometry with a diameter of 85 cm, a strip
length of 100 cm, a cross-section of 4 mm × 20 mm and silicon photomultipliers with an additional
layer of wavelength shifter as the readout, the spatial resolution (full width at half maximum) in
the centre of the scanner is equal to 3 mm (radial, tangential) and 6 mm (axial). For the analogous
double-layer geometry with the same readout, diameter and scintillator length, with a strip crosssection
of 7 mm × 20 mm, a noise equivalent count rate peak of 300 kcps was reached at 40 kBq cc?1
activity concentration, the scatter fraction is estimated to be about 35% and the sensitivity at the
centre amounts to 14.9 cps kBq?1. Sensitivity profiles were also determined.
A Method to Produce Linearly Polarized Positrons and Positronium Atoms with the J-PET Detector
M. Mohammed, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B.C. Hiesmayr, B. Jasińska, D. Kisielewska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, L. Raczyński, J. Raj, Z. Rudy, N.G. Sharma, S. Sharma, Shivani, M. Skurzok, M. Silarski, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A method for creating linearly polarized positrons and ortho-positronium (o-Ps) atoms with the J-PET detector is presented. The unique geometry and properties of the J-PET tomography enable one to design a positron source such that the quantization axis for the estimation of the linear polarization of produced o-Ps can be determined on the event by event basis in a direction of the positron motion. We intend to use 22Na or other beta+ decay isotopes as a source of polarized positrons. Due to the parity violation in the beta decay, the emitted positrons are longitudinally polarized. The choice of the quantization axis is based on the known position of the positron emitter and the reconstructed position of the positronium annihilation. We show that the J-PET tomography is equipped with all needed components.
Human Tissue Investigations Using PALS Technique - Free Radicals Influence
B. Jasińska, B. Zgardzińska, G. Chołubek, M. Pietrow, M. Gorgol, K. Wiktor, K. Wysogląd, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, B.C. Hiesmayr, B. Jodłowska-Jędrych, D. Kamińska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, H. Wiktor, W. Wiślicki, M. Zieliński, P. Moskal
abstract
The positron annihilation lifetime spectroscopy was applied to the samples of the human uterine leiomyomas and the normal myometrium tissues taken from the selected place of the uterus during a surgery. The method indicated differences in values of the measured positron annihilation lifetime spectroscopy parameters (lifetimes and intensities) between healthy and diseased tissue samples. The additional measurements were performed either in darkness or in presence of visible light which influenced the free radicals present in both kind of tissues and, as a result, made changes in free annihilation and o-Ps decay lifetime and intensity values.
Preliminary Studies of J-PET Detector Spatial Resolution
M. Pawlik-Niedźwiecka, S. Niedźwiecki, D. Alfs, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. C. Hiesmayr, B. Jasińska, D. Kisielewska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pałka, L. Raczyński, J. Raj, Z. Rudy, Shivani, M. Silarski, M. Skurzok, N.G. Sharma, S. Sharma, R.Y. Shopa, A. Strzelecki, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
The J-PET detector, based on long plastic scintillator strips, was recently constructed at the Jagiellonian University. It consists of 192 modules axially arranged into three layers, read out from both sides by digital constant-threshold front-end electronics. This work presents preliminary results of measurements of the spatial resolution of the J-PET tomograph performed with 22Na source placed at selected position inside the detector chamber.
Analysis procedure of the positronium lifetime spectra for the J-PET detector
K. Dulski , B. Zgardzińska , P. Białas , C. Curceanu E. Czerwiński , A. Gajos , B. Głowacz , M. Gorgol , B. C. Hiesmayr , B. Jasińska , D. Kisielewska-Kamińska , G. Korcyl , P. Kowalski , T. Kozik , N. Krawczyk , W. Krzemień , E. Kubicz , M. Mohammed , M. Pawlik-Niedźwiecka, S. Niedźwiecki , M. Pałka , L. Raczyński , J. Raj , Z. Rudy , N. G. Sharma, S. Sharma, Shivani, R. Y. Shopa, M. Silarski , M. Skurzok , A. Wieczorek , W. Wiślicki , M. Zieliński , P. Moskal
abstract
Positron Annihilation Lifetime Spectroscopy (PALS) has shown to be a powerful tool to study the nanostructures of porous materials. Positron Emissions Tomography (PET) are devices allowing imaging of metabolic processes e.g. in human bodies. A newly developed device, the J-PET (Jagiellonian PET), will allow PALS in addition to imaging, thus combining both analyses providing new methods for physics and medicine. In this contribution we present a computer program that is compatible with the J-PET software. We compare its performance with the standard program LT 9.0 by using PALS data from hexane measurements at different temperatures. Our program is based on an iterative procedure, and our fits prove that it performs as good as LT 9.0.
Introduction of total variation regularization into filtered backprojection algorithm
L. Raczyński, W. Wiślicki, K. Klimaszewski, W. Krzemień, P. Kowalski, R. Shopa, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, N.G. Sharma, S. Sharma, M. Silarski, M. Skurzok, A. Wieczorek, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
In this paper we extend the state-of-the-art filtered backprojection (FBP) method with application of the concept of Total Variation regularization. We compare the performance of the new algorithm with the most common form of regularizing in the FBP image reconstruction via apodizing functions. The methods are validated in terms of cross-correlation coefficient between reconstructed and real image of radioactive tracer distribution using standard Derenzo-type phantom. We demonstrate that the proposed approach results in higher cross-correlation values with respect
to the standard FBP method.
Time calibration of the J-PET detector
M. Skurzok, M. Silarski, D. Alfs, P. Bialas, Shivani, C. Curceanu , E. Czerwinski , K. Dulski , A. Gajos, B. G lowacz , M. Gorgol, B. C. Hiesmayr, B. Jasinska, D. Kisielewska, G. Korcyl, P. Kowalski, T. Kozik , N. Krawczyk, W. Krzemien, E. Kubicz , M. Mohammed, M. Pawlik-Niedzwiecka, S. Niedzwiecki, M. Palka, L. Raczynski , J. Raj, Z. Rudy, N. G. Sharma, S. Sharma , R. Y. Shopa , A. Wieczorek, W. Wislicki , B. Zgardzinska, M. Zielinski, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) project carried out in the Institute of Physics of the Jagiellonian University is focused on construction and tests of the first prototype of PET scanner for medical diagnostic which allows for the simultaneous 3D imaging of the whole human body using organic scintillators. The J-PET prototype consists of 192 scintillator strips forming three cylindrical layers which are optimized for the detection of photons from the electron-positron annihilation with high time- and high angular-resolutions. In this article we present time calibration and synchronization of the whole J-PET detection system by irradiating each single detection module with a 22Na source and a small detector providing common reference time for synchronization of all the modules.
Novel scintillating material 2-(4-styrylphenyl)benzoxazole for the fully digital and MRI compatible J-PET tomograph based on plastic scintillators
A. Wieczorek, K. Dulski, Sz. Niedźwiecki, D. Alfs, P. Białas, C. Curceanu, E. Czerwiński, A. Danel, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Kucharek, M. Mohammed, M. Pawlik-Niedźwiecka, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N. G. Sharma, M. Silarski, T. Uchacz, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel
plastic
scintillator
is developed
for
the
application
in the
digital
positron
emission
tomography
(PET).
The
novelty
of the
concept
lies
in application
of the
2-(4-styrylphenyl)
benzoxazole
as
a wavelength
shifter.
The
substance
has
not
been
used
as
scintillator
dop-
ant
before.
A dopant
shifts
the
scintillation
spectrum
towards
longer
wavelengths
making
it
more
suitable
for
applications
in scintillators
of long
strips
geometry
and
light
detection
with
digital
silicon
photomultipliers.
These
features
open
perspectives
for
the
construction
of the
cost-effective
and
MRI-compatib
le PET
scanner
with
the
large
field
of view.
In this
article
we
present
the
synthesis
method
and
characterize
performance
of the
elaborated
scintillator
by
determining
its
light
emission
spectrum,
light
emission
efficiency,
rising
and
decay
time
of
the
scintillation
pulses
and
resulting
timing
resolution
when
applied
in the
positron
emission
tomography.
The
optimal
concentratio
n of the
novel
wavelength
shifter
was
established
by
maximizing
the
light
output
and
it was
found
to be
0.05
?
for
cuboidal
scintillator
with
dimen-
sions
of 14
mm
x 14
mm
x 20
mm.
Commissioning of the J-PET Detector for Studies of Decays of Positronium Atoms
E. Czerwiński, K. Dulski, P. Białas, C. Curceanu, A. Gajos, B. Głowacz, M. Gorgol, B.C. Hiesmayr, B. Jasińska, D. Kisielewska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R.Y. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is a detector for medical imaging of the whole human body as well as for physics studies involving detection of electron?positron annihilation into photons. J-PET has high angular and time resolution, and allows for measurement of spin of the positronium and the momenta and polarization vectors of annihilation quanta. In this article, we present the potential of the J-PET system for the background rejection in the decays of positronium atoms.
A New PET Diagnostic Indicator Based on the Ratio of 3gamma/2gamma Positron Annihilation
B. Jasińska, P. Moskal
abstract
The idea of applying the ratio of 3g and 2g positron annihilation rate as a diagnostic indicator in the PET imaging is proposed. It is based on the fact that the 3g annihilation is related to the decay rate of triplet state of positronium atoms produced inside the human body during the PET imaging, and it reflects the size and the concentration of free volumes present in the investigated tissues. The tissues deformation related to the cancerous changes are expected to influence the local value of the 3g fraction.
J-PET: A New Technology for the Whole-body PET Imaging
S. Niedźwiecki, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B.C. Hiesmayr, B. Jasińska, Ł. Kapłon, D. Kisielewska-Kamińska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R.Y. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET built from plastic scintillators. J-PET prototype consists of 192 detection modules arranged axially in three layers forming a cylindrical diagnostic chamber with the inner diameter of 85 cm and the axial field-of-view of 50 cm. An axial arrangement of long strips of plastic scintillators, their small light attenuation, superior timing properties, and relative ease of the increase of the axial field-of-view opens promising perspectives for the cost effective construction of the whole-body PET scanner, as well as construction of MR and CT compatible PET inserts. Present status of the development of the J-PET tomograph will be presented and discussed.
Three-dimensional Image Reconstruction in J-PET Using Filtered Back-projection Method
R.Y. Shopa, K. Klimaszewski, P. Kowalski, W. Krzemień, L. Raczyński, W. Wiślicki, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, N.G. Sharma, S. Sharma, M. Silarski, M. Skurzok, A. Wieczorek, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
We present a method and preliminary results of the image reconstruction in the Jagiellonian PET tomograph. Using GATE (Geant4 Application for Tomographic Emission), interactions of the 511 keV photons with a cylindrical detector were generated. Pairs of such photons, flying back-to-back, originate from e+e? annihilations inside a 1 mm spherical source. Spatial and temporal coordinates of hits were smeared using experimental resolutions of the detector. We incorporated the algorithm of the 3D Filtered Back Projection, implemented in the STIR and TomoPy software packages, which differ in approximation methods. Consistent results for the Point Spread Functions of ? 5 ÷ 7 mm and ? 9 ÷ 20 mm were obtained, using STIR, for transverse and longitudinal directions, respectively, with no time-of-flight information included.
Human Tissues Investigation Using PALS Technique
B. Jasińska, B. Zgardzińska, G. Chołubek, M. Gorgol, K. Wiktor, K. Wysogląd, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, B.C. Hiesmayr, B. Jodłowska-Jędrych, D. Kamińska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, H. Wiktor, W. Wiślicki, M. Zieliński, P. Moskal
abstract
Samples of uterine leiomyomatis and normal tissues taken from patients
after surgery were investigated using the Positron Annihilation Lifetime
Spectroscopy (PALS). Significant differences in all PALS parameters
between normal and diseased tissues were observed. For all studied patients,
it was found that the values of the free annihilation and orthopositronium
lifetime are larger for the tumorous tissues than for the healthy
ones. For most of the patients, the intensity of the free annihilation and
ortho-positronium annihilation was smaller for the tumorous than for the
healthy tissues. For the first time, in this kind of studies, the 3gamma fraction
of positron annihilation was determined to describe changes in the tissue
porosity during morphologic alteration.
Multichannel FPGA based MVT system for high precision time (20 ps RMS) and charge measurement
M. Palka, P. Strzempek, G. Korcyl, T. Bednarski, S. Niedzwiecki, P. Bialas, E. Czerwinski, K. Dulski, A. Gajos, B. Glowacz, M. Gorgol, B. Jasinska, D. Kaminska, M. Kajetanowicz, P. Kowalski, T. Kozik, W. Krzemien, E. Kubicz, M. Mohhamed, L. Raczynski, Z. Rudy, O. Rundel, P. Salabura, NG. Sharma, M. Silarski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wislicki, M. Zielinski, B. Zgardzinska, P. Moskal
abstract
In this article it is presented an FPGA based Multi-Voltage Threshold (MVT) system which allows of sampling fast signals (1-2 ns rising and falling edge) in both voltage and time domain. It is possible to achieve a precision of time measurement of 20 ps RMS and reconstruct charge of signals, using a simple approach, with deviation from real value smaller than 10%. Utilization of the differential inputs of an FPGA chip as comparators together with an implementation of a TDC inside an FPGA allowed us to achieve a compact multi-channel system characterized by low power consumption and low production costs. This paper describes realization and functioning of the system comprising 192-channel TDC board and a four mezzanine cards which split incoming signals and discriminate them. The boards have been used to validate a newly developed Time-of-Flight Positron Emission Tomography system based on plastic scintillators. The achieved full system time resolution of sigma (TOF) approximate to 68 ps is by factor of two better with respect to the current TOF-PET systems.
Calculation of the time resolution of the J-PET tomograph using kernel density estimation
L. Raczyński, W. Wiślicki, W. Krzemień, P. Kowalski, D. Alfs, T. Bednarski, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, J. Smyrski, A. Strzelecki, A. Wieczorek, B. Zgardzińska, M. Zieliński and P. Moskal
abstract
In this paper we estimate the time resolution of the J-PET scanner built from plastic scintillators. We incorporate the method of signal processing using the Tikhonov regularization framework and the kernel density estimation method. We obtain simple, closed-form analytical formulae for time resolution. The proposed method is validated using signals registered by means of the single detection unit of the J-PET tomograph built from a 30?cm long plastic scintillator strip. It is shown that the experimental and theoretical results obtained for the J-PET scanner equipped with vacuum tube photomultipliers are consistent.
Measurement of gamma quantum interaction point in plastic scintillator with WLS strips
J. Smyrski, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, N. Gupta-Sharma, M. Gorgol, B. Jasińska, M. Kajetanowicz, D. Kamińska, G. Korcyl, P. Kowalski, W. Krzemień, N. Krawczyk, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, P. Salabura, M. Silarski, A. Strzelecki, A. Wieczorek, W. Wiślicki, J. Wojnarska, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
The feasibility of measuring the aśxial coordinate of a gamma quantum interaction point in a plastic scintillator
bar via the detection of scintillation photons escaping from the scintillator with an array of wavelength-shifting
(WLS) strips is demonstrated. Using a test set-up comprising a BC-420 scintillator bar and an array of sixteen
BC-482A WLS strips we achieved a spatial resolution of 5 mm (?) for annihilation photons from a 22Na isotope.
The studied method can be used to improve the spatial resolution of a plastic-scintillator-based PET scanner
which is being developed by the J-PET collaboration.
J-PET: A Novel TOF -PET scanner using Organic Scintillators
N.G. Sharma, M. Silarski, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. Jasińska, D. Kamińska, G. Korcyl, P. Kowalski, W. Krzemień, N. Krawczyk, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, O. Rundel, A. Wieczorek, W. Wislicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
Positron Emission Tomography (PET) is one of the most advanced nuclear medicine imaging techniques that
have potential to identify many diseases (like cancers, heart diseases, neurological disorders and other abnormalities) in vivo in the earliest stages. However, production of PET modalities for covering the whole human body is economically unrealistic when applying the current technologies. In order to achieve a goal of more economical PET scanner with large geometrical acceptance and improved time resolution, the Jagiellonian Positron Emission Tomography (J-PET) Collaboration is realizing a new project aiming at construction of TOF-PET detector using plastic scintillators instead of crystals. Novelty of the J-PET scanner lies in: (i) application of plastic scintillators as well as in (ii) its front-end electronics which allows signal sampling in voltage domain, (iii) a trigger-less data acquisition system, and (iv) the new time and hit-position reconstruction methods. Moreover, the proposed solution enables to increase the axial field-of-view of the tomograph by extending the length of the plastic scintillator strips without changing the number of photomultipliers and electronic channels.
A feasibility study of ortho-positronium decays measurement with the J-PET scanner based on plastic scintillators
D. Kamińska, A. Gajos, E. Czerwiński, D. Alfs, T. Bednarski, P. Białas, C. Curceanu, K. Dulski, B. Głowacz, N. Gupta-Sharma, M. Gorgol, B. C. Hiesmayr, B. Jasińska, G. Korcyl, P. Kowalski, W. Krzemień, N. Krawczyk, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, M. Silarski, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
We present a study of the application of the Jagiellonian Positron Emission Tomograph (J-PET) for the registration of gamma quanta from decays of ortho-positronium (o-Ps). The J-PET is the first positron emission tomography scanner based on organic scintillators in contrast to all current PET scanners based on inorganic crystals. Monte Carlo simulations show that the J-PET as an axially symmetric and high acceptance scanner can be used as a multi-purpose detector well suited to pursue research including e.g. tests of discrete symmetries in decays of ortho-positronium in addition
to the medical imaging. The gamma quanta originating from o-Ps decay interact in the plastic scintillators predominantly via the Compton effect, making the direct measurement of their energy impossible. Nevertheless, it is shown in this paper that the J-PET scanner will enable studies of the o-Ps->3g decays with angular and energy resolution equal to sigma(theta) = 0.4^{circ} and sigma(E) = 4.1 keV, respectively. An order of magnitude shorter decay time of signals from plastic scintillators with respect to the inorganic crystals results not only in better timing properties crucial for the reduction of physical and instrumental background, but also suppresses significantly the pileups, thus enabling compensation of the lower efficiency of the plastic scintillators by performing measurements with higher positron source activities.
Determination of the 3gamma Fraction from Positron Annihilation in Mesoporous Materials for Symmetry Violation Experiment with J-PET Scanner
B. Jasińska, M. Gorgol, M. Wiertel, R. Zaleski, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos B. Głowacz, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
Various mesoporous materials were investigated to choose the best material for experiments requiring high yield of long-lived positronium. We found that the fraction of 3? annihilation determined using ?-ray energy spectra and positron annihilation lifetime spectra (PAL) changed from 20% to 25%. The 3? fraction and o-Ps formation probability in the polymer XAD-4 is found to be the largest. Elemental analysis performed using scanning electron microscope (SEM) equipped with energy-dispersive X-ray spectroscope EDS shows high purity of the investigated materials.
Sampling FEE and Trigger-less DAQ for the J-PET Scanner
G. Korcyl, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, B. Jasińska, D. Kamińska Ł. Kapłon, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, K. Stoła, A. Strzelecki, A. Wieczorek, W. Wiślicki, B.K. Zgardzińska, M. Zieliński, P. Moskal
abstract
In this paper, we present a complete Data Acquisition System (DAQ) together with the readout mechanisms for the J-PET tomography scanner. In general, detector readout chain is constructed out of Front-End Electronics (FEE) measurement devices such as Time-to-Digital or Analog-to-Digital Converters (TDCs or ADCs), data collectors and storage. We have developed a system capable for maintaining continuous readout of digitized data without preliminary selection. Such operation mode results in up to 8 Gbps data stream, therefore, it is required to introduce a dedicated module for on-line event building and feature extraction. The Central Controller Module, equipped with Xilinx Zynq SoC and 16 optical transceivers, serves as such true real time computing facility. Our solution for the continuous data recording (trigger-less) is a novel approach in such detector systems and assures that most of the information is preserved on the storage for further, high-level processing. Signal discrimination applies a unique method of using LVDS buffers located in the FPGA fabric.
Beam Profile Investigation of the New Collimator System for the J-PET Detector
E. Kubicz, M. Silarski, A. Wieczorek, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, B. Głowacz, B. Jasińska D. Kamińska, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, M. Mohammed, I. Moskal, S. Niedźwiecki, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, A. Strzelecki, W. Wiślicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
Jagiellonian Positron Emission Tomograph (J-PET) is a multi-purpose detector which will be used for search for discrete symmetries violations in the decays of positronium atoms and for investigations with positronium atoms in life-sciences and medical diagnostics. In this article, we present three methods for determination of the beam profile of collimated annihilation gamma quanta. Precise monitoring of this profile is essential for time and energy calibration of the J-PET detector and for the determination of the library of model signals used in the hit-time and hit-position reconstruction. We have shown that usage of two lead bricks with dimensions of 5 × 10 × 20 cm3 enables to form a beam of annihilation quanta with Gaussian profile characterized by 1 mm FWHM. Determination of this characteristic is essential for designing and construction the collimator system for the 24-module J-PET prototype. Simulations of the beam profile for different collimator dimensions were performed. This allowed us to choose optimal collimation system in terms of the beam profile parameters, dimensions and weight of the collimator taking into account the design of the 24-module J-PET detector.
Scatter Fraction of the J-PET Tomography Scanner
P. Kowalski, W. Wiślicki, L. Raczyński, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, B. Głowacz, J. Jasińska D. Kamińska, G. Korcyl, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammad, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, Z. Rudy, M. Silarski, A. Wieczorek, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel Positron Emission Tomography system, based on plastic scintillators, is being developed by the J-PET Collaboration. In this article, we present the simulation results of the scatter fraction, representing one of the parameters crucial for background studies defined in the NEMA-NU-2-2012 norm. We elaborate an event selection methods allowing to suppress events in which gamma quanta were scattered in the phantom or underwent the multiple scattering in the detector. The estimated scatter fraction for the single-layer J-PET scanner varies from 37% to 53% depending on the applied energy threshold.
Application of the compress sensing theory for improvement of the TOF resolution in a novel J-PET instrument
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, N. Gupta-Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
Trilateration-based reconstruction of ortho-positronium decays into three photons with the J-PET detector
A. Gajos, D. Kamińska, E. Czerwiński, D. Alfs, T. Bednarski, P. Białas, B. Głowacz, M. Gorgol, B. Jasińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
This work reports on a new reconstruction algorithm allowing us to reconstruct the decays of ortho-positronium atoms into three photons using the places and times of photons recorded in the detector. The method is based on trilateration and allows for a simultaneous reconstruction of both location and time of the decay. Results of resolution tests of the new reconstruction in the J-PET detector based on Monte Carlo simulations are presented, which yield a spatial resolution at the level of 2 cm (FWHM) for X and Y and at the level of 1 cm (FWHM) for Z available with the present resolution of J-PET after application of a kinematic fit. Prospects of employment of this method for studying angular correlations of photons in decays of polarized ortho-positronia for the needs of tests of CP and CPT discrete symmetries are also discussed. The new reconstruction method allows for discrimination of background from random three-photon coincidences as well as for application of a novel method for determination of the linear polarization of ortho-positronium atoms, which is also introduced in this work.
Time resolution of the plastic scintillator strips with matrix photomultiplier readout for J-PET tomograph
P. Moskal, O. Rundel, D. Alfs, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, K. Giergiel, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, A. Słomski, M. Silarski, A. Strzelecki, A. Wieczorek, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Recent tests of a single module of the Jagiellonian Positron Emission
Tomography system (J-PET) consisting of 30 cm long plastic scintillator
strips have proven its applicability for the detection of annihilation quanta
(0.511 MeV) with a coincidence resolving time (CRT) of 0.266 ns. The
achieved resolution is almost by a factor of two better with respect to the
current TOF-PET detectors and it can still be improved since, as it is shown
in this article, the intrinsic limit of time resolution for the determination of
time of the interaction of 0.511 MeV gamma quanta in plastic scintillators
is much lower. As the major point of the article, a method allowing to
record timestamps of several photons, at two ends of the scintillator strip,
by means of matrix of silicon photomultipliers (SiPM) is introduced. As a
result of simulations, conducted with the number of SiPM varying from 4 to 42, it is shown that the improvement of timing resolution saturates with
the growing number of photomultipliers, and that the 2×5 configuration at
two ends allowing to read twenty timestamps, constitutes an optimal solution.
The conducted simulations accounted for the emission time distribution,
photon transport and absorption inside the scintillator, as well as quantum
efficiency and transit time spread of photosensors, and were checked based on
the experimental results. Application of the 2×5 matrix of SiPM allows for
achieving the coincidence resolving time in positron emission tomography of
0.170 ns for 15 cm axial field-of-view (AFOV) and 0.365 ns for 100 cm
AFOV. The results open perspectives for construction of a cost-effective TOFPET
scanner with significantly better TOF resolution and larger AFOV with
respect to the current TOF-PET modalities.
Overview of the software architecture and data flow for the J-PET tomography device
W. Krzemień, D. Alfs, P. Białas, E. Czerwiński, A. Gajos, B. Głowacz, B. Jasińska, D. Kamińska, G. Korcyl, P. Kowalski, T. Kozik, E. Kubicz, Sz. Niedźwiecki, M. Pawlik-Niedźwiecka, L. Raczyński, Z. Rudy, M. Silarski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, P. Moskal
abstract
Modern TOF-PET scanner systems require high-speed computing resources for efficient data processing, monitoring and image reconstruction. In this article we present the data flow and software architecture for the novel TOF-PET scanner developed by the J-PET collaboration. We discuss the data acquisition system, reconstruction framework and some image reconstruction issues. Also, the concept of computing outside hospitals in the remote centers such as 'Swierk Computing Centre in Poland is presented
Potential of the J-PET Detector for Studies of Discrete Symmetries in Decays of Positronium Atom - a Purely Leptonic System
P. Moskal, D. Alfs, T. Bednarski, P. Białas, E. Czerwinski, C. Curceanu, A. Gajos, B. Głowacz, M. Gorgol, B.C. Hiesmayr, B. Jasinska, D. Kaminska, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemien , N. Krawczyk, E. Kubicz, M. Mohammed, Sz. Niedzwiecki, M. Pawlik-Niedzwiecka, L. Raczynski, Z. Rudy, M. Silarski, A. Wieczorek, W. Wislicki, M. Zielinski
abstract
The Jagiellonian Positron Emission Tomograph (J-PET) was constructed
as a prototype of the cost-effective scanner for the simultaneous
metabolic imaging of the whole human body. Being optimized for the detection
of photons from the electron?positron annihilation with high timeand
high angular-resolution, it constitutes a multi-purpose detector providing
new opportunities for studying the decays of positronium atoms.
Positronium is the lightest purely leptonic object decaying into photons.
As an atom bound by a central potential, it is a parity eigenstate, and
as an atom built out of an electron and an anti-electron, it is an eigenstate
of the charge conjugation operator. Therefore, the positronium is
a unique laboratory to study discrete symmetries whose precision is limited,
in principle, by the effects due to the weak interactions expected at the level of (10????14) and photon?photon interactions expected at the
level of (10????9). The J-PET detector enables to perform tests of discrete
symmetries in the leptonic sector via the determination of the expectation
values of the discrete-symmetries-odd operators, which may be constructed
from the spin of ortho-positronium atom and the momenta and polarization
vectors of photons originating from its annihilation. In this article, we
present the potential of the J-PET detector to test the C, CP, T and CPT
symmetries in the decays of positronium atoms.
Searches for discrete symmetries violation in ortho-positronium decay using the J-PET detector
D. Kamińska, A. Gajos, E. Czerwiński, T. Bednarski, P. Białas, M. Gorgol, B. Jasińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
In this paper, we present prospects for using the Jagiellonian positron emission tomograph (J-PET)
detector to search for discrete symmetries violations in a purely leptonic system of the positronium atom. We
discuss tests of CP and CPT symmetries by means of ortho-positronium decays into three photons. No zero
expectation values for chosen correlations between ortho-positronium spin and momentum vectors of photons
would imply the existence of physics phenomena beyond the standard model. Previous measurements resulted
in violation amplitude parameters for CP and CPT symmetries consistent with zero, with an uncertainty of
about 10?3. The J-PET detector allows to determine those values with better precision, thanks to the unique
time and angular resolution combined with a high geometrical acceptance. Achieving the aforementioned is possible
because of the application of polymer scintillators instead of crystals as detectors of annihilation quanta.
Studies of unicellular microorganisms Saccharomyces cerevisiae by means of positron annihilation lifetime spectroscopy
E. Kubicz, B. Jasińska, B. Zgardzińska, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rajfur, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, P. Moskal
abstract
Results of positron annihilation lifetime spectroscopy (PALS) and microscopic studies on simple microorganisms,
brewing yeasts, are presented. Lifetime of ortho-positronium (o-Ps) were found to change from 2.4 to 2.9 ns
(longer-lived component) for lyophilized and aqueous yeasts, respectively. Also hygroscopicity of yeasts in time was
examined, allowing to check how water ? the main component of the cell ? affects PALS parameters, thus lifetime
of o-Ps were found to change from 1.2 to 1.4 ns (shorter-lived component) for the dried yeasts. The time suffi cient
to hydrate the cells was found below 10 hours. In the presence of liquid water, an indication of reorganization of
yeast in the molecular scale was observed. Microscopic images of the lyophilized, dried, and wet yeasts with best
possible resolution were obtained using inverted microscopy (IM) and environmental scanning electron microscopy
(ESEM) methods. As a result, visible changes to the surface of the cell me mbrane were observed in ESEM images.
Reconstruction of hit time and hit position of annihilation quanta in the J-PET detector usi ng the Mahalanobis distance
N. G. Sharma, M. Silarski, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, A. Słomski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, B. Zgardzińska, P. Moskal
abstract
The J-PET detector being developed at Jagiellonian University, is a Positron Emission Tomograph composed of the long strips of polymer scintillators. At the same time it is a detector system which will be used for studies of the decays of positronium atoms. The shape of photomultiplier signals depends on the hit-time and hit-position of the gamma quantum. In order to take advantage of this fact a dedicated sampling front-end electronics which enables to sample signals in voltage domain with the time precision of about 20 ps and novel reconstruction method based on the comparison of examined signal with the model signals stored in the library has been developed. As a measure of the similarity we use the Mahalanobis distance. The achievable position and time-resolution depends on number and values of the threshold levels at which the signal is sampled. A reconstruction method, as well as preliminary results are presented and discussed.
PALS investigations of free volumes thermal expansion of J-PET plastic scintillator synthesized in polystyrene matrix
A. Wieczorek, B. Zgardzińska, B. Jasińska, M. Gorgol, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, W. Wiślicki, M. Zieliński, P. Moskal
abstract
The polystyrene dopped with 2,5-diphenyloxazole as a primary fluor and 2-(4-styrylphenyl)benzoxazole as a wavelength shifter, prepared as a plastic scintillator was investigated using positronium probe in wide range of temperatures from 123 to 423 K. Three structural transitions at 260 K, 283 K and 370 K were found in the material. In the o-Ps intensity dependence on temperature, the significant hysteresis is observed. Heated to 370 K, the material exhibits the o-Ps intensity variations in time.
Processing optimization with parallel computing for the J-PET scanner
W. Krzemień, M. Bała, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, M. Gorgol, B. Jasińska, D. Kamińska, Ł. Kapłon, G. Korcyl, P. Kowalski, T. Kozik, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N.G. Sharma, M. Silarski, A. Słomski, K. Stola, A. Strzelecki, D. Trybek, Anna Wieczorek, W. Wiślicki, M. Zieliński, B. K. Zgardzińska, P. Moskal
abstract
The Jagiellonian-PET (J-PET) collaboration is developing a prototype TOF-PET detector based on long polymer scintillators. This novel approach exploits the excellent time properties of the plastic scintillators, which permit very precise time measurements. The very fast, FPGA-based front-end electronics and the data acquisition system, as well as, low- and high-level reconstruction algorithms were specially developed to be used with the J-PET scanner. The TOF-PET data processing and reconstruction are time and resource demanding operations, especially in case of a large acceptance detector, which works in triggerless data acquisition mode. In this article, we discuss the parallel computing methods applied to optimize the data processing for the J-PET detector. We begin with general concepts of parallel computing and then we discuss several applications of those techniques in the J-PET data processing.
Multiple Scattering and Accidental Coincidences in the J-PET Detector Simulated Using GATE Package
P. Kowalski, P. Moskal, W. Wislicki, L. Raczynski, T. Bednarski, P. Bialas, J. Bulka, E. Czerwinski, A. Gajos, A. Gruntowski, D. Kaminska, L. Kaplon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemien, E. Kubicz, S. Niedzwiecki, M. Palka, Z. Rudy, P. Salabura, NG. Sharma, M. Silarski, A. Slomski, J. Smyrski, A. Strzelecki, A. Wieczorek, I. Wochlik, M. Zielinski, N. Zon
abstract
Novel positron emission tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.
A pilot study of the novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter
A. Wieczorek, P. Moskal, Sz. Niedźwiecki, T. Bednarski, P. Białas, E. Czerwiński, A. Danel, A. Gajos, A. Gruntowski, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, T. Uchacz, W. Wiślicki, M. Zieliński, N. Zoń
abstract
For the first time a molecule of 2-(4-styrylphenyl)benzoxazole containing benzoxazole and stilbene groups is applied as a scintillator dopant acting as a wavelength shifter. In this article a light yield of the plastic scintillator, prepared from styrene doped with 2 wt% of 2,5-diphenylbenzoxazole and 0.03 wt% of 2-(4-styrylphenyl)benzoxazole, is determined to be as large as 60% ? 2% of the anthracene light output. There is a potential to improve this value in the future by the optimization of the additives concentrations.
Compressive sensing of signals generated in plastic scintillators in a novel J-PET instrument
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
The J-PET scanner, which allows for single bed imaging of the whole human body, is currently under development at the Jagiellonian University. The discussed detector offers improvement of the Time of Flight (TOF) resolution due to the use of fast plastic scintillators and dedicated electronics allowing for sampling in the voltage domain of signals with durations of few nanoseconds. In this paper we show that recovery of the whole signal, based on only a few samples, is possible. In order to do that, we incorporate the training signals into the Tikhonov regularization framework and we perform the Principal Component Analysis decomposition, which is well known for its compaction properties. The method yields a simple closed form analytical solution that does not require iterative processing. Moreover, from the Bayes theory the properties of regularized solution, especially its covariance matrix, may be easily derived. This is the key to introduce and prove the formula for calculations of the signal recovery error. In this paper we show that an average recovery error is approximately inversely proportional to the number of acquired samples.
Analysis framework for the J-PET scanner
W. Krzemień, A. Gajos, A. Gruntowski, K. Stola, D. Trybek, T. Bednarski, P. Białas, E. Czerwiński, D. Kamińska, L. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, E. Kubicz, P. Moskal, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński, N. Zoń
abstract
J-PET analysis framework is a flexible, lightweight, ROOT-based software package which provides the tools to develop reconstruction and calibration procedures for PET tomography. In this article we present the implementation of the full data-processing chain in the J-PET framework which is used for the data analysis of the J-PET tomography scanner. The Framework incorporates automated handling of PET setup parameters' database as well as high level tools for building data reconstruction procedures. Each of these components is briefly discussed.
Hit time and hit position reconstruction in the J-PET detector based on a library of averaged model signals
P. Moskal, N.G.Sharma, M.Silarski, T. Bednarski, P. Białas, J. Bułka, E. Czerwiński, A. Gajos, D. Kamińska, L. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki, I. Wochlik, M. Zieliński, N. Zoń
abstract
In this article we present a novel method of hit time and hit position reconstruction in long scintillator detectors. We take advantage of the fact that for this kind of detectors amplitude and shape of registered signals depends strongly on the position where particle hit the detector. The reconstruction is based on determination of the degree of similarity between measured and averaged signals stored in a library for a set of well-defined positions along the scintillator. Preliminary results of validation of the introduced method with experimental data obtained by means of the double strip prototype of the J-PET detector are presented.
GPU accelerated image reconstruction in a two-strip J-PET tomograph
P. Białas, J. Kowal, A. Strzelecki, T. Bednarski, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, P. Moskal, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Wieczorek, W. Wiślicki, M. Zieliński, N. Zoń
abstract
We present a fast GPU implementation of the image reconstruction routine, for a novel two strip PET detector that relies solely on the time of flight measurements.
A novel method for the line-of-response and time-of-flight reconstruction in TOF-PET detectors based on a library of synchronized model signals
P. Moskal, N. Zoń, T. Bednarski, P. Białas, E. Czerwiński, A. Gajos, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, Sz. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki, M. Zieliński
abstract
A novel method of hit time and hit position reconstruction in scintillator detectors is described. The method is based on comparison of detector signals with results stored in a library of synchronized model signals registered for a set of well-defined positions of scintillation points. The hit position is reconstructed as the one corresponding to the signal from the library which is most similar to the measurement signal. The time of the interaction is determined as a relative time between the measured signal and the most similar one in the library. A degree of similarity of measured and model signals is defined as the distance between points representing the measurement- and model-signal in the multi-dimensional measurement space. Novelty of the method lies also in the proposed way of synchronization of model signals enabling direct determination of the difference between time-of-flights (TOF) of annihilation quanta from the annihilation point to the detectors. The introduced method was validated using experimental data obtained by means of the double strip prototype of the J-PET detector and 22Na sodium isotope as a source of annihilation gamma quanta.The detector was built out from plastic scintillator strips with dimensions of 5 mm x 19 mm x 300 mm, optically connected at both sides to photomultipliers,from which signals were sampled by means of the Serial Data Analyzer.Using the introduced method, the spatial and TOF resolution of about 1.3 cm (?) and 125 ps (?) were established, respectively.
Test of a single module of the J-PET scanner based on plastic scintillators
P. Moskal, Sz. Niedźwiecki, T. Bednarski, E. Czerwiński, Ł. Kapłon, E. Kubicz, I. Moskal, M. Pawlik-Niedźwiecka, N.G. Sharma, M. Silarski, M. Zieliński, N. Zoń, P. Białas, A. Gajos, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, M. Pałka, L. Raczyński, Z. Rudy, P. Salabura, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wiślicki
abstract
Time of Flight Positron Emission Tomography scanner based on plastic scintillators is being developed at the Jagiellonian University by the J-PET collaboration. The main challenge of the conducted research lies in the elaboration of a method allowing application of plastic scintillators for the detection of low energy gamma quanta. In this article we report on tests of a single detection module built out from BC-420 plastic scintillator strip (with dimensions of 5x19x300mm^3) read out at two ends by Hamamatsu R5320 photomultipliers. The measurements were performed using collimated beam of annihilation quanta from the 68Ge isotope and applying the Serial Data Analyzer (Lecroy SDA6000A) which enabled sampling of signals with 50ps intervals. The time resolution of the prototype module was established to be better than 80ps (sigma) for a single level discrimination. The spatial resolution of the determination of the hit position along the strip was determined to be about 0.93cm (sigma) for the annihilation quanta. The fractional energy resolution for the energy E deposited by the annihilation quanta via the Compton scattering amounts to sigma(E)/E = 0.044/sqrt(E[MeV]) and corresponds to the sigma(E)/E of 7.5% at the Compton edge.
Novel method for hit-position reconstruction using voltage signals in plastic scintillators and its application to Positron Emission Tomography
L. Raczyński, P. Moskal, P. Kowalski, W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic scintillators which would allow for single bed imaging of the whole human body. This paper describes a novel method of hit-position reconstruction based on sampled signals and an example of an application of the method for a single module with a 30 cm long plastic strip, read out on both ends by Hamamatsu R4998 photomultipliers. The sampling scheme to generate a vector with samples of a PET event waveform with respect to four user-defined amplitudes is introduced. The experimental setup provides irradiation of a chosen position in the plastic scintillator strip with an annihilation gamma quanta of energy 511 keV. The statistical test for a multivariate normal (MVN) distribution of measured vectors at a given position is developed, and it is shown that signals sampled at four thresholds in a voltage domain are approximately normally distributed variables. With the presented method of a vector analysis made out of waveform samples acquired with four thresholds, we obtain a spatial resolution of about 1 cm and a timing resolution of about 80 ps (sigma).
Computing support for advanced medical data analysis and imaging
W. Wiślicki, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, S. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, M. Zieliński, N. Zoń
abstract
We discuss computing issues for data analysis and image reconstruction of PET-TOF medical scanner or other medical scanning devices producing large volumes of data. Service architecture based on the grid and cloud concepts for distributed processing is proposed and critically discussed.
A novel method based solely on FPGA units enabling measurement of time and charge of analog signals in Positron Emission Tomography
M. Pałka, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article presents a novel technique for precise measurement of time and charge based solely on FPGA (Field Programmable Gate Array) device and few satellite discrete electronic components used in Positron Emission Tomography (PET). Described approach simplifies electronic circuits, reduces the power consumption, lowers costs, merges front-end electronics with digital electronics and also makes more compact final design. Furthermore, it allows to measure time when analog signals cross a reference voltage at different threshold levels with a very high precision of ? 10ps (rms) and thus enables sampling of signals in a voltage domain.
A novel method for calibration and monitoring of time synchronization of TOF-PET scanners by means of cosmic rays
M. Silarski, E. Czerwiński, T. Bednarski, P. Moskal, P. Białas, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
All of the present methods for calibration and monitoring of TOF-PET scanner detectors utilize radioactive isotopes such as e.g. 22Na or 68Ge, which are placed or rotate inside the scanner. In this article we describe a novel method based on the cosmic rays application to the PET calibration and monitoring methods. The concept allows to overcome many of the drawbacks of the present methods and it is well suited for newly developed TOF-PET scanners with a large longitudinal field of view. The method enables also monitoring of the quality of the scintillator materials and in general allows for the continuous quality assurance of the PET detector performance.
3D PET image reconstruction based on the maximum likelihood estimation method (MLEM) algorithm
A. Słomski, Z. Rudy, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, P. Salabura, N. G. Sharma, M. Silarski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
A positron emission tomography (PET) scan does not measure an image directly. Instead, a PET scan measures a sinogram at the boundary of the field-of-view that consists of measurements of the sums of all the counts along the lines connecting the two detectors. Because there is a multitude of detectors built in a typical PET structure, there are many possible detector pairs that pertain to the measurement. The problem is how to turn this measurement into an image (this is called imaging). Significant improvement in PET image quality was achieved with the introduction of iterative reconstruction techniques. This was realized approximately 20 years ago (with the advent of new powerful computing processors). However, three-dimensional imaging still remains a challenge. The purpose of the image reconstruction algorithm is to process this imperfect count data for a large number (many millions) of lines of response and millions of detected photons to produce an image showing the distribution of the labeled molecules in space.
Trigger-less and reconfigurable data acquisition system for positron emission tomography
G. Korcyl, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article is focused on data acquisition system (DAQ) designed especially to be used in positron emission tomography (PET) or single-photon emission computed tomography. The system allows for continuous registration of analog signals during measurement. It has been designed to optimize registration and processing of the information carried by signals from the detector system in PET scanner. The processing does not require any rejection of data with a trigger system. The proposed system possesses also an ability to implement various data analysis algorithms that can be performed in real time during data collection.
Determination of the map of efficiency of the Jagiellonian Positron Emission Tomograph (J-PET) detector with the GATE package
P. Kowalski, L. Raczyński, T. Bednarski, P. Białas, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
A novel PET detector consisting of strips of polymer scintillators is being developed by the J-PET Collaboration. The map of efficiency and the map of geometrical acceptance of the 2-strip J-PET scanner are presented. Map of efficiency was determined using the Monte Carlo simulation software GATE based on GEANT4. Both maps were compared using method based on the chi2 test.
Plastic scintillators for positron emission tomography obtained by the bulk polymerization method
Ł. Kapłon, A. Kochanowski, M. Molenda, P. Moskal, A. Wieczorek, T. Bednarski, P. Białas, E. Czerwiński, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This paper describes three methods regarding the production of plastic scintillators. One method appears to be suitable for the manufacturing of plastic scintillators, revealing properties which fulfill the requirements of novel positron emission tomography scanners based on plastic scintillators. The key parameters of the manufacturing process are determined and discussed.
J-PET analysis framework for the prototype TOF-PET detector
W. Krzemień, M. Silarski, K. Stola, D. Trybek, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, A. Słomski, J. Smyrski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
Novel TOF-PET scanner solutions demand, apart from the state of the art detectors, software for fast processing of the gathered data, monitoring of the whole scanner and reconstruction of the PET image. In this article we present an analysis framework for the novel STRIP-PET scanner developed by the J-PET collaboration in the Institute of Physics of the Jagiellonian University. This software is based on the ROOT package used in many particle physics experiments.
Database and data structure for the novel TOF-PET detector developed for J-PET project
E. Czerwiński, M. Zieliński, T. Bednarski, P. Białas, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Molenda, P. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N. G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, A. Wieczorek, W.Wiślicki, N. Zoń
abstract
The complexity of the hardware and the amount of data collected during the PET imaging process require application of modern methods of efficient data organization and processing. In this article we will discuss the data structures and the flow of collected data from the novel TOF-PET medical scanner which is being developed at the Jagiellonian University. The developed data format reflects: registration process of the gamma quanta emitted from positron-electron annihilation, Front-End Electronic (FEE) structure and required input information for the image reconstruction. In addition, the system database fulfills possible demands of the evolving J-PET project.
Calibration of photomultipliers gain used in the J-PET detector
T. Bednarski, E. Czerwiński, P. Moskal, P. Białas, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Photomultipliers are commonly used in commercial PET scanner as devices which convert light produced in scintillator by gamma quanta from positron-electron annihilation into electrical signal. For proper analysis of obtained electrical signal, a photomultiplier gain curve must be known, since gain can be significantly different even between photomultipliers of the same model. In this article we describe single photoelectron method used for photomultipliers calibration applied for J-PET scanner, a novel PET detector being developed at the Jagiellonian University. Description of calibration method, an example of calibration curve and gain of few R4998 Hamamatsu photomultipliers are presented.
List-mode reconstruction in 2D strip PET
P. Białas, J. Kowal, A. Strzelecki, T. Bednarski, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, P. Moskal, S. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, K. Szymański, W. Wiślicki, P. Witkowski, M. Zieliński, N. Zoń
abstract
Using a theory of list-mode maximum likelihood
expectation-maximization (MLEM) algorithm, in this contribution,
we present a derivation of the system response
kernel for a novel positron emission tomography (PET)
detector based on plastic scintillators.
Simulations of gamma quanta scattering in a single module of the J-PET detector
K. Szymański, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, K. Giergiel, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, I. Moskal, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, J. Smyrski, A. Strzelecki, P. Witkowski, W. Wiślicki, M. Zieliński, N. Zoń
abstract
This article describes simulations of scattering of annihilation gamma quanta in a strip of plastic scintillator. Such strips constitute basic detection modules in a newly proposed Positron Emission Tomography which utilizes plastic scintillators instead of inorganic crystals. An algorithm simulating chain of Compton scatterings was elaborated and series of simulations have been conducted for the scintillator strip with the cross section of 5 mm x 19 mm. Obtained results indicate that secondary interactions occur only in the case of about 8% of events and out of them only 25% take place in the distance larger than 0.5 cm from the primary interaction. It was also established that light signals produced at primary and secondary interactions overlap with the delay which distribution is characterized by FWHM of about 40 ps.
Application of WLS strips for position determination in Strip PET tomograph based on plastic scintillators
J. Smyrski, P. Moskal, T. Bednarski, P. Białas, E. Czerwiński, Ł. Kapłon, A. Kochanowski, G. Korcyl, J. Kowal, P. Kowalski, T. Kozik, W. Krzemień, M. Molenda, Sz. Niedźwiecki, M. Pałka, M. Pawlik, L. Raczyński, Z. Rudy, P. Salabura, N.G. Sharma, M. Silarski, A. Słomski, A. Strzelecki, W. Wiślicki, M. Zieliński, N. Zoń
abstract
A method of determination of a gamma quantum absorption point in a plastic scintillator block using a matrix of wavelength-shifting (WLS) strips is proposed. Application of this method for improvement of position resolution in newly proposed PET detectors based on plastic scintillators is presented. The method enables to reduce parallax errors in reconstruction of images which occurs in the presently used Positron Emission Tomography scanners.
TOF-PET detector concept based on organic scintillators
P. Moskal, T. Bednarski, P. Białas, M. Ciszewska, E. Czerwiński, A. Heczko, M. Kajetanowicz, Ł. Kapłon, A. Kochanowski, G. Konopka-Cupiał, G. Korcyl, W. Krzemień, K. Łojek, J. Majewski, W. Migdał, M. Molenda, S. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, M. Silarski, A. Słomski, J. Smyrski, J. Zdebik, M. Zieliński
abstract
In this contribution we present a new concept of the large acceptance detector systems based on organic scintillators which may allow for simultaneous diagnostic of large fraction of the human body. Novelty of the concept lies in employing large blocks of polymer scintillators instead of crystals as detectors of annihilation quanta, and in using predominantly the timing of signals instead of their amplitudes.
Strip-PET: a novel detector concept for the TOF-PET scanner
P. Moskal, T. Bednarski, P. Białas, M. Ciszewska, E. Czerwiński, A. Heczko, M. Kajetanowicz, Ł. Kapłon, A. Kochanowski, G. Konopka-Cupiał, G. Korcyl, W. Krzemień, K. Łojek, J. Majewski, W. Migdał, M. Molenda, S. Niedźwiecki, M. Pałka, Z. Rudy, P. Salabura, M. Silarski, A. Słomski, J. Smyrski, J. Zdebik, M. Zieliński
abstract
We briefly present a design of a new PET scanner based on
strips of polymer scintillators arranged in a barrel constituting
a large acceptance detector. The solution proposed is based on
the superior timing properties of the polymer scintillators. The
position and time of the reaction of the gamma quanta in the
detector material will be determined based on the time of arrival
of light signals to the edges of the scintillator strips.
