Realistic Total-Body J-PET Geometry Optimization--Monte Carlo Study
J. Baran, W. Krzemień, L. Raczyński, M. Bała, A. Coussat, S. Parzych, N. Chug, E. Czerwiński, C. Oana Curceanu, M. Dadgar, K. Dulski, K. Eliyan, J. Gajewski, A. Gajos, B. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, G. Korcyl, T. Kozik, D. Kumar, S. Niedźwiecki, D. Panek, E. Perez del Rio, A. Ruciński, S. Sharma, Shivani, R.Y. Shopa, M. Skurzok, E. Stępień, F. Tayefiardebili, K. Tayefiardebili, W. Wiślicki, P. Moskal
abstract
Comparative studies of plastic scintillator strips with high technical attenuation length for the total-body J-PET scanner
Ł. Kapłon, J. Baran, N. Chug, A. Coussat, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, B. Hiesmayr, E. Kavya Valsan, K. Klimaszewski, G. Korcyl, T. Kozik, W. Krzemień, D. Kumar, G. Moskal, S. Niedźwiecki, D. Panek, S. Parzych, E. Pérez del Rio, L. Raczyński, A. Ruciński, S. Sharma, S. Shivani, R. Shopa, M. Silarski, M. Skurzok, E. Stępień, F. Tayefi Ardebili, K. Tayefi Ardebili, W. Wiślicki, P. Moskal
abstract
Plastic scintillator strips are considered as one of the promising solutions for the cost-effective construction of total-body positron emission tomography, (PET) system. The purpose of the performed measurements is to compare the transparency of long plastic scintillators with dimensions 6 mm
24 mm
1000 mm and with all surfaces polished. Six different types of commercial, general purpose, blue-emitting plastic scintillators with low attenuation of visible light were tested, namely: polyvinyl toluene-based BC-408, EJ-200, RP-408, and polystyrene-based Epic, SP32 and UPS-923A. For determination of the best type of plastic scintillator for total-body Jagiellonian positron emission tomograph (TB-J-PET) construction, emission and transmission spectra, and technical attenuation length (TAL) of blue light-emitting by the scintillators were measured and compared. The TAL values were determined with the use of UV lamp as excitation source, and photodiode as light detector. Emission spectra of investigated scintillators have maxima in the range from 420 nm to 429 nm. The BC-408 and EJ-200 have the highest transmittance values of about 90% at the maximum emission wavelength measured through a 6 mm thick scintillator strip and the highest technical attenuation length reaching about 2000 mm, allowing assembly of long detection modules for time-of-flight (TOF) J-PET scanners. Influence of the 6 mm × 6 mm, 12 mm × 6 mm, 24 mm × 6 mm cross-sections of the 1000 mm long EJ-200 plastic scintillator on the TAL and signal intensity was measured. The highest TAL value was determined for samples with 24 mm × 6 mm cross-section.
Testing CPT symmetry in ortho-positronium decays with positronium annihilation tomography
P. Moskal, A. Gajos, M. Mohammed, J. Chhokar, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, M. Gorgol, J. Goworek, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi, D. Kisielewska, K. Klimaszewski, G. Korcyl, P. Kowalski, N. Krawczyk, W. Krzemień, T. Kozik, E. Kubicz, S. Niedźwiecki, S. Parzych, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, S. Choudhary, R. Shopa, A. Sienkiewicz, M. Silarski, M. Skurzok, E. Stepien, F. Tayefi, W. Wiślicki
abstract
Charged lepton system symmetry under combined charge, parity, and time-reversal transformation (CPT) remain scarcely tested. Despite stringent quantum-electrodynamic limits, discrepancies in predictions for the electron-positron bound state (positronium atom) motivate further investigation, including fundamental symmetry tests. While CPT noninvariance effects could be manifested in non-vanishing angular correlations between final-state photons and spin of annihilating positronium, measurements were previously limited by the knowledge of the latter. Here, we demonstrate tomographic reconstruction techniques applied to three-photon annihilations of ortho-positronium atoms to estimate their spin polarisation without a magnetic field or polarised positronium source. We use a plastic-scintillator-based positron-emission-tomography scanner to record ortho-positronium (o-Ps) annihilations with a single-event estimation of o-Ps spin and determine the complete spectrum of an angular correlation operator sensitive to CPT-violating effects. We find no violation at the precision level of 10^{-4}, with an over threefold improvement on the previous measurement.
3D TOF-PET image reconstruction using total variation regularization
L. Raczyński, W. Wiślicki, K. Klimaszewski, W. Krzemień, P. Kopka, P. Kowalski, R. Y. Shopa, M. Bała, J. Chhokar, C. Curceanu, E. Czerwinski, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. Hiesmayr, B. Jasińska, K. Kacprzak, L. Kapłon, D. Kisielewska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, S. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, J. Raj, K. Rakoczy, A. Ruciński, S. Sharma, S. Shivani, M. Silarski, M. Skurzok, E.Ł. Stepień, B. Zgardzińska, P. Moskal
abstract
In this paper we introduce a semi-analytic algorithm for 3-dimensional image reconstruction for positron emission tomography (PET). The method consists of the back-projection of the acquired data into the most likely image voxel according to time-of-flight (TOF) information, followed by the filtering step in the image space using an iterative optimization algorithm with a total variation (TV) regularization. TV regularization in image space is more computationally efficient than usual iterative optimization methods for PET reconstruction with a full system matrix that uses TV regularization. The efficiency comes from the one-time TOF back-projection step that might also be described as a reformatting of the acquired data. An important aspect of our work concerns the evaluation of the filter operator of the linear transform mapping an original radioactive tracer distribution into the TOF back-projected image. We obtain concise, closed-form analytical formula for the filter operator. The proposed method is validated with the Monte Carlo simulations of the NEMA IEC phantom using a one-layer, 50 cm-long cylindrical device called Jagiellonian PET scanner. The results show a better image quality compared with the reference TOF maximum likelihood expectation maximization algorithm.
Feasibility study of the positronium imaging with the J-PET tomograph
P. Moskal, D. Kisielewska, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, G. Korcyl, P. Kowalski, W. Krzemień, T. Kozik, E. Kubicz, M. Mohammed, Sz. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, L. Raczyński, J. Raj, S. Sharma, Shivani, R.Y. Shopa, M. Silarski, M. Skurzok, E. Stępień, W. Wiślicki, B. Zgardzińska
abstract
A detection system of the conventional PET tomograph is set-up to record data from e+ e- annihilation into two photons with energy of 511 keV, and it gives information on the density distribution of a radiopharmaceutical in the body of the object. In this paper we explore the possibility of performing the three gamma photons imaging based on ortho- positronium annihilation, as well as the possibility of positronium average lifetime imaging with the J-PET tomograph constructed from plastic scintillators. For this purposes simulations of the ortho-positronium formation and its annihilation into three photons were performed taking into account distributions of photons' momenta as predicted by the theory of quantum electrodynamics and the response of the J-PET tomograph. In order to test the proposed ortho-positronium lifetime image reconstruction method, we concentrate on the decay of the ortho-positronium into three photons and applications of radiopharmaceuticals labeled with isotopes emitting a prompt gamma quantum. The proposed method of imaging is based on the determination of hit-times and hit-positions of registered photons which enables the reconstruction of the time and position of the annihilation point as well as the lifetime of the ortho-positronium on an event-by-event basis. We have simulated the production of the positronium in a cylindrical phantom composed of a set of different materials in which the ortho-positronium lifetime varied from 2 ns to ~2.9 ns, as expected for ortho-positronium created in the human body. The presented reconstruction method for total-body J-PET like detector allows to achieve a mean lifetime resolution of about 40 ps. Recent Positron Annihilation Lifetime Spectroscopy measurements of cancerous and healthy uterine tissues show that this sensitivity may allow to study the morphological changes in cell structures.
Estimating the NEMA characteristics of the J-PET tomograph using the GATE package
P. Kowalski, W. Wiślicki, R.Y. Shopa, L. Raczyński, K. Klimaszewski, C. Curcenau, E. Czerwiński, K. Dulski, A. Gajos, M. Gorgol, N. Gupta-Sharma, B. Hiesmayr, B. Jasińska, Ł. Kapłon, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, W. Krzemień, E. Kubicz, M. Mohammed, S. Niedźwiecki, M. Pałka, M. Pawlik-Niedźwiecka, J. Raj, K. Rakoczy, Z. Rudy, S. Sharma, S. Shivani, M. Silarski, M. Skurzok, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel whole-body positron emission tomography (PET) system based on plastic scintillators is
developed by the J-PET Collaboration. It consists of plastic scintillator strips arranged axially in the
form of a cylinder, allowing the cost-effective construction of the total-body PET system. In order to
determine the properties of the scanner prototype and optimize its geometry, advanced computer
simulations were performed using the GATE (Geant4 application for tomographic emission)
software.
The spatial resolution, sensitivity, scatter fraction and noise equivalent count rate were estimated
according to the National Electrical Manufacturers Association norm, as a function of the length
of the tomograph, the number of detection layers, the diameter of the tomographic chamber and
for various types of applied readout. For the single-layer geometry with a diameter of 85 cm, a strip
length of 100 cm, a cross-section of 4 mm × 20 mm and silicon photomultipliers with an additional
layer of wavelength shifter as the readout, the spatial resolution (full width at half maximum) in
the centre of the scanner is equal to 3 mm (radial, tangential) and 6 mm (axial). For the analogous
double-layer geometry with the same readout, diameter and scintillator length, with a strip crosssection
of 7 mm × 20 mm, a noise equivalent count rate peak of 300 kcps was reached at 40 kBq cc?1
activity concentration, the scatter fraction is estimated to be about 35% and the sensitivity at the
centre amounts to 14.9 cps kBq?1. Sensitivity profiles were also determined.
Introduction of total variation regularization into filtered backprojection algorithm
L. Raczyński, W. Wiślicki, K. Klimaszewski, W. Krzemień, P. Kowalski, R. Shopa, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, N.G. Sharma, S. Sharma, M. Silarski, M. Skurzok, A. Wieczorek, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
In this paper we extend the state-of-the-art filtered backprojection (FBP) method with application of the concept of Total Variation regularization. We compare the performance of the new algorithm with the most common form of regularizing in the FBP image reconstruction via apodizing functions. The methods are validated in terms of cross-correlation coefficient between reconstructed and real image of radioactive tracer distribution using standard Derenzo-type phantom. We demonstrate that the proposed approach results in higher cross-correlation values with respect
to the standard FBP method.
Novel scintillating material 2-(4-styrylphenyl)benzoxazole for the fully digital and MRI compatible J-PET tomograph based on plastic scintillators
A. Wieczorek, K. Dulski, Sz. Niedźwiecki, D. Alfs, P. Białas, C. Curceanu, E. Czerwiński, A. Danel, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, K. Kacprzak, D. Kamińska, Ł. Kapłon, A. Kochanowski, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemień, E. Kubicz, M. Kucharek, M. Mohammed, M. Pawlik-Niedźwiecka, M. Pałka, L. Raczyński, Z. Rudy, O. Rundel, N. G. Sharma, M. Silarski, T. Uchacz, W. Wiślicki, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
A novel
plastic
scintillator
is developed
for
the
application
in the
digital
positron
emission
tomography
(PET).
The
novelty
of the
concept
lies
in application
of the
2-(4-styrylphenyl)
benzoxazole
as
a wavelength
shifter.
The
substance
has
not
been
used
as
scintillator
dop-
ant
before.
A dopant
shifts
the
scintillation
spectrum
towards
longer
wavelengths
making
it
more
suitable
for
applications
in scintillators
of long
strips
geometry
and
light
detection
with
digital
silicon
photomultipliers.
These
features
open
perspectives
for
the
construction
of the
cost-effective
and
MRI-compatib
le PET
scanner
with
the
large
field
of view.
In this
article
we
present
the
synthesis
method
and
characterize
performance
of the
elaborated
scintillator
by
determining
its
light
emission
spectrum,
light
emission
efficiency,
rising
and
decay
time
of
the
scintillation
pulses
and
resulting
timing
resolution
when
applied
in the
positron
emission
tomography.
The
optimal
concentratio
n of the
novel
wavelength
shifter
was
established
by
maximizing
the
light
output
and
it was
found
to be
0.05
?
for
cuboidal
scintillator
with
dimen-
sions
of 14
mm
x 14
mm
x 20
mm.
Three-dimensional Image Reconstruction in J-PET Using Filtered Back-projection Method
R.Y. Shopa, K. Klimaszewski, P. Kowalski, W. Krzemień, L. Raczyński, W. Wiślicki, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kisielewska-Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, N.G. Sharma, S. Sharma, M. Silarski, M. Skurzok, A. Wieczorek, B. Zgardzińska, M. Zieliński, P. Moskal
abstract
We present a method and preliminary results of the image reconstruction in the Jagiellonian PET tomograph. Using GATE (Geant4 Application for Tomographic Emission), interactions of the 511 keV photons with a cylindrical detector were generated. Pairs of such photons, flying back-to-back, originate from e+e? annihilations inside a 1 mm spherical source. Spatial and temporal coordinates of hits were smeared using experimental resolutions of the detector. We incorporated the algorithm of the 3D Filtered Back Projection, implemented in the STIR and TomoPy software packages, which differ in approximation methods. Consistent results for the Point Spread Functions of ? 5 ÷ 7 mm and ? 9 ÷ 20 mm were obtained, using STIR, for transverse and longitudinal directions, respectively, with no time-of-flight information included.
Human Tissues Investigation Using PALS Technique
B. Jasińska, B. Zgardzińska, G. Chołubek, M. Gorgol, K. Wiktor, K. Wysogląd, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, B. Hiesmayr, B. Jodłowska-Jędrych, D. Kamińska, G. Korcyl, P. Kowalski, T. Kozik, N. Krawczyk, W. Krzemień, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, L. Raczyński, Z. Rudy, N.G. Sharma, S. Sharma, R. Shopa, M. Silarski, M. Skurzok, A. Wieczorek, H. Wiktor, W. Wiślicki, M. Zieliński, P. Moskal
abstract
Samples of uterine leiomyomatis and normal tissues taken from patients after surgery were investigated using the Positron Annihilation Lifetime Spectroscopy (PALS). Significant differences in all PALS parameters between normal and diseased tissues were observed. For all studied patients, it was found that the values of the free annihilation and ortho-positronium lifetime are larger for the tumorous tissues than for the healthy ones. For most of the patients, the intensity of the free annihilation and ortho-positronium annihilation was smaller for the tumorous than for the healthy tissues. For the first time, in this kind of studies, the 3? fraction of positron annihilation was determined to describe changes in the tissue porosity during morphologic alteration.
Calculation of the time resolution of the J-PET tomograph using kernel density estimation
L. Raczyński, W. Wiślicki, W. Krzemień, P. Kowalski, D. Alfs, T. Bednarski, P. Białas, C. Curceanu, E. Czerwiński, K. Dulski, A. Gajos, B. Głowacz, M. Gorgol, B. Hiesmayr, B. Jasińska, D. Kamińska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedźwiecka, S. Niedźwiecki, M. Pałka, Z. Rudy, O. Rundel, N. Gupta-Sharma, M. Silarski, J. Smyrski, A. Strzelecki, A. Wieczorek, B. Zgardzińska, M. Zieliński and P. Moskal
abstract
In this paper we estimate the time resolution of the J-PET scanner built from plastic scintillators. We incorporate the method of signal processing using the Tikhonov regularization framework and the kernel density estimation method. We obtain simple, closed-form analytical formulae for time resolution. The proposed method is validated using signals registered by means of the single detection unit of the J-PET tomograph built from a 30?cm long plastic scintillator strip. It is shown that the experimental and theoretical results obtained for the J-PET scanner equipped with vacuum tube photomultipliers are consistent.
J-PET: A Novel TOF-PFT Detector based on Plastic Scintillators
P. Moskal, D. Alfs, T. Bednarski, P. Bialas, C. Curceanu, E. Czerwinski, K. Dulski, A. Gajos, B. Glowacz, M. Gorgol, B. Hiesmayr, B. Jasinska, D. Kaminska, G. Korcyl, P. Kowalski, T. Kozik, W. Krzemien, E. Kubicz, M. Mohammed, M. Pawlik-Niedzwiecka, S. Niedzwiecki, M. Palka, L. Raczynski, Z. Rudy, O. Rundel, NG. Sharma, M. Silarski, J. Smyrski, A. Strzelecki, A. Wieczorek, W. Wislicki, B. Zgardzinska, M. Zielinski
abstract
The purpose of the reported research is the elaboration of the method for construction of the cost-effective whole body single-bed positron emission tomography scanner enabling simultaneous PET/CT and PET/MR imaging The Jagiellonian Positron Emission Tomograph (J-PET) is built out of 192 scintillator strips arranged axially in three layers forming a cylindrical diagnostic chamber with the diameter of 85 cm and axial field of-view of 50 cm. The novelty of the concept lies in employing long strips of plastic scintillators instead of crystals as detectors of the annihilation quanta, and in using the timing of signals instead of their amplitudes for the reconstruction of Lines-of Response. To take advantage of the superior timing properties of plastic scintillators a novel multi-voltage-threshold front-end electronics was developed allowing for sampling of signals in a voltage domain. An axial arrangement of long strips of plastic scintillators, and their small light attenuation allows us to make a TOE-PET scanner with a long axial field-of-view. The presented solution opens unique possibilities of combining PET with CT and PET with MRI for scanning the same part of a patient at the same time with both methods. The relative ease of the cost effective increase of the axial field-of-view makes the J-PET tomograph competitive with respect to the current commercial PET scanners as regards sensitivity and time resolution.
Statistical Analysis of Time Resolution of the J-PET Scanner
L. Raczynski, W. Wislicki, P. Kowalski, W. Krzemien, D. Alfs, T. Bednarski, P. Bialas, C. Curceanu, E. Czerwinski, K. Dulski, A. Gajos, B. Glowacz, M. Gorgol, B. Hiesmayr, B. Jasinska, D. Kaminska, G. Korcyl, T. Kozik, N. Krawczyk, E. Kubicz, M. Mohammed, M. Pawlik-Niedzwiecka, S. Niedzwiecki, M. Palka, Z. Rudy, O. Rundel, NG. Sharma, M. Silarski, J. Smyrski, A. Strzelecki, A. Wieczorek, B. Zgardzinska, M. Zielinski, P. Moskal
abstract
The commercial Positron Emission Tomography (PET) scanners use inorganic crystal scintillators for the detection of gamma photons. The Jagiellonian-PET (J-PET) detector exhibits high time resolution due to use of fast plastic scintillators and dedicated electronics circuits. Since the time resolution of PET scanner is influenced by numerous factors, e.g. a type of photomultipliers attached to the scintillators, the optimal selection of components of the J-PET system requires detailed understanding of the method for calculation the time resolution. In this paper we show the idea of this method, based on statistical analysis of the observed signals on the photomultiplier's output. The method is tested using signals registered by means of the single detection module of the J-PET scanner built out from 30 cm long plastic scintillator strips. We investigate two main factors affecting the photon registration probability, photomultipliers quantum efficiency and photomultipliers transit time spread. We demonstrate that the quantum efficiency of photomultipliers represents the most important factor influencing overall performance of the J-PET scanner.
